Table 1

Univariate analysis on prognostic factors in 297 MLL+ ALL patients according to risk group stratification

Medium riskHigh riskMedium risk + high riskEvents, no. (%)4-year EFS (SE)P*
Overall 200 97 297 185 36.8 (2.9)  
Age at diagnosis      < .001 
    < 3 mo 37 46 83 62 (75) 24.4 (5.5)  
    ≥ 3-6 mo or older 44 51 95 65 (68) 30.5 (5.1)  
    ≥ 6-9 mo or older 70 0 70 39 (56) 42.6 (6.1)  
    ≥ 9-12 mo or older 49 0 49 19 (39) 61.9 (7.1)  
WBC counts      < .001 
    < 100 g/L 97 8† 105 51 (49) 49.9 (5.0)  
    ≥ 100-300 g/L 74 16† 90 57 (63) 36.9 (5.3)  
    ≥ 300 g/L 29 73 102 77 (75) 23.2 (5.0)  
Prednisone response      < .001 
    GPR 169 31 200 111 (56) 43.2 (3.6)  
    PPR 31 66 97 74 (76) 23.5 (5.1)  
Immunophenotype      .51‡ 
    B-cell, CD10− 144 81 225 138 (61) 38.0 (3.3)  
    B-cell, CD10+ 37 10 47 33 (70) 27.8 (6.8)  
    B-cell, CD10 (unknown) 16 6 22 13 (59) 40.9 (10.6)  
    T-cell 2 0 2 1 (50) NA  
    Biphenotypic 1 0 1 0 NA  
Medium riskHigh riskMedium risk + high riskEvents, no. (%)4-year EFS (SE)P*
Overall 200 97 297 185 36.8 (2.9)  
Age at diagnosis      < .001 
    < 3 mo 37 46 83 62 (75) 24.4 (5.5)  
    ≥ 3-6 mo or older 44 51 95 65 (68) 30.5 (5.1)  
    ≥ 6-9 mo or older 70 0 70 39 (56) 42.6 (6.1)  
    ≥ 9-12 mo or older 49 0 49 19 (39) 61.9 (7.1)  
WBC counts      < .001 
    < 100 g/L 97 8† 105 51 (49) 49.9 (5.0)  
    ≥ 100-300 g/L 74 16† 90 57 (63) 36.9 (5.3)  
    ≥ 300 g/L 29 73 102 77 (75) 23.2 (5.0)  
Prednisone response      < .001 
    GPR 169 31 200 111 (56) 43.2 (3.6)  
    PPR 31 66 97 74 (76) 23.5 (5.1)  
Immunophenotype      .51‡ 
    B-cell, CD10− 144 81 225 138 (61) 38.0 (3.3)  
    B-cell, CD10+ 37 10 47 33 (70) 27.8 (6.8)  
    B-cell, CD10 (unknown) 16 6 22 13 (59) 40.9 (10.6)  
    T-cell 2 0 2 1 (50) NA  
    Biphenotypic 1 0 1 0 NA  

ALL indicates acute lymphoblastic leukemia; EFS, event-free survival; SE, standard error; WBC, white blood cell; GPR, good prednisone response; PPR, poor prednisone response; and NA, not applicable.

*

P values are based on log-rank test.

†

These patients had a PPR.

‡

In B-cell only.

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