Comparison of genetic alterations between patients with AML who have lower and higher LGALS3 expression
| Variant . | Number (%) of patients with the gene mutation . | P value . | ||
|---|---|---|---|---|
| Whole cohort (n = 280) . | Lower LGALS3 expression (n = 140) . | Higher LGALS3 expression (n = 140) . | ||
| CEBPA | 39 (13.9) | 27 (19.3) | 12 (8.6) | .015 |
| CEBPAsingle-mut | 11 (3.9) | 8 (5.7) | 3 (2.1) | .125 |
| CEBPAdouble-mut | 28 (10) | 19 (13.6) | 9 (6.4) | .045 |
| FLT3-ITD | 71 (25.4) | 44 (31.4) | 27 (19.3) | .028 |
| NPM1 | 74 (26.4) | 35 (25) | 39 (27.9) | .684 |
| FLT3-TKD | 21 (7.5) | 11 (7.9) | 10 (7.1) | >.999 |
| PTPN11 | 16 (5.7) | 2 (1.4) | 14 (10) | .003 |
| RAS | 42 (15) | 17 (12.1) | 25 (17.9) | .241 |
| MLL-PTD | 15 (5.4) | 6 (4.3) | 9 (6.4) | .597 |
| KIT | 9 (3.2) | 5 (3.6) | 4 (2.9) | .75 |
| WT1 | 21 (7.5) | 12 (8.6) | 9 (6.4) | .651 |
| AML1/RUNX1 | 37 (13.2) | 13 (9.3) | 24 (17.1) | .077 |
| ASXL1 | 29 (10.4) | 16 (11.4) | 13 (9.3) | .695 |
| IDH1 | 17 (6.1) | 12 (8.6) | 5 (3.6) | .131 |
| IDH2 | 39 (13.9) | 17 (12.1) | 22 (15.7) | .49 |
| TET2 | 38 (13.6) | 13 (9.3) | 25(17.9) | .054 |
| Variant . | Number (%) of patients with the gene mutation . | P value . | ||
|---|---|---|---|---|
| Whole cohort (n = 280) . | Lower LGALS3 expression (n = 140) . | Higher LGALS3 expression (n = 140) . | ||
| CEBPA | 39 (13.9) | 27 (19.3) | 12 (8.6) | .015 |
| CEBPAsingle-mut | 11 (3.9) | 8 (5.7) | 3 (2.1) | .125 |
| CEBPAdouble-mut | 28 (10) | 19 (13.6) | 9 (6.4) | .045 |
| FLT3-ITD | 71 (25.4) | 44 (31.4) | 27 (19.3) | .028 |
| NPM1 | 74 (26.4) | 35 (25) | 39 (27.9) | .684 |
| FLT3-TKD | 21 (7.5) | 11 (7.9) | 10 (7.1) | >.999 |
| PTPN11 | 16 (5.7) | 2 (1.4) | 14 (10) | .003 |
| RAS | 42 (15) | 17 (12.1) | 25 (17.9) | .241 |
| MLL-PTD | 15 (5.4) | 6 (4.3) | 9 (6.4) | .597 |
| KIT | 9 (3.2) | 5 (3.6) | 4 (2.9) | .75 |
| WT1 | 21 (7.5) | 12 (8.6) | 9 (6.4) | .651 |
| AML1/RUNX1 | 37 (13.2) | 13 (9.3) | 24 (17.1) | .077 |
| ASXL1 | 29 (10.4) | 16 (11.4) | 13 (9.3) | .695 |
| IDH1 | 17 (6.1) | 12 (8.6) | 5 (3.6) | .131 |
| IDH2 | 39 (13.9) | 17 (12.1) | 22 (15.7) | .49 |
| TET2 | 38 (13.6) | 13 (9.3) | 25(17.9) | .054 |