Antiproliferative activity of AT9283 in a panel of human CML cell lines
| Cell line . | BCR-ABL status . | Additional characteristics . | IC50, nM . |
|---|---|---|---|
| Imatinib sensitive | |||
| BV173 | + | 55 | |
| KU812 | + | 26 | |
| MYL | + | 21 | |
| KT-1 | + | 81 | |
| KBM-5 | + | 84 | |
| MEG-01 | + | 31 | |
| K562 | + | Polyploidy at 100 | |
| Imatinib resistant | |||
| KBM-5/STIR | + | T315I mutation | 16 |
| BV173/shBim | + | Bim knockdown | 12 |
| HL60 | − | Polyploidy at 30 | |
| Jurkat | − | Polyploidy at 500 | |
| Nalm6 | − | Polyploidy at 140 | |
| KG1a | − | Polyploidy at 55 |
| Cell line . | BCR-ABL status . | Additional characteristics . | IC50, nM . |
|---|---|---|---|
| Imatinib sensitive | |||
| BV173 | + | 55 | |
| KU812 | + | 26 | |
| MYL | + | 21 | |
| KT-1 | + | 81 | |
| KBM-5 | + | 84 | |
| MEG-01 | + | 31 | |
| K562 | + | Polyploidy at 100 | |
| Imatinib resistant | |||
| KBM-5/STIR | + | T315I mutation | 16 |
| BV173/shBim | + | Bim knockdown | 12 |
| HL60 | − | Polyploidy at 30 | |
| Jurkat | − | Polyploidy at 500 | |
| Nalm6 | − | Polyploidy at 140 | |
| KG1a | − | Polyploidy at 55 |