The association between γ′ fibrinogen, γ′/total fibrinogen ratio, and total fibrinogen and traditional CVD risk factors
| CVD risk factor . | γ′ fibrinogen (mg/mL) . | γ′/total fibrinogen ratio (%) . | Total fibrinogen (mg/mL) . |
|---|---|---|---|
| BMI, kg/m2 | |||
| <18.5 | 0.28 (0.20-0.42) (n = 303) | 9.24 (9.06-13.4) (n = 288) | 2.95 (2.20-4.80) (n = 306) |
| 18.5-24.9 | 0.28 (0.21-0.41) (n = 732) | 10.3 (7.19-14.7) (n = 712) | 2.60 (2.10-4.10) (n = 741) |
| 25-29.9 | 0.35 (0.24-0.46) (n = 298) | 10.6 (7.39-15.3) (n = 285) | 2.90 (2.30-5.00) (n = 302) |
| ≥30 | 0.38 (.029-0.56) (n = 345) | 10.4 (7.33-15.1) (n = 327) | 3.70 (2.60-6.20) (n = 338) |
| Unadjusted P value | <.0001 | .001 | <.0001 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| Waist circumference, cm | |||
| Normal | 0.28 (0.21-0.40) (n = 1150) | 9.98 (7.12-14.3) (n = 1112) | 2.60 (2.10-4.10) (n = 1167) |
| Abdominal obesity | 0.38 (0.28-0.53) (n = 605) | 10.4 (7.28-15.2) (n = 574) | 3.30 (2.50-5.90) (n = 559) |
| Unadjusted P value | <.0001 | .067 | <.0001 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| HDL cholesterol, mmol/L | |||
| Normal (≥1.0) | 0.29 (0.22-0.43) (n = 1224) | 9.76 (6.84-14.2) (n = 1175) | 2.80 (2.20-4.80) (n = 1228) |
| Low (<1.0) | 0.35 (0.26-0.51) (n = 514) | 11.1 (8.03-15.3) (n = 496) | 3.00 (2.30-5.50) (n = 521) |
| Unadjusted P value | <.0001 | <.0001 | .009 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| Metabolic syndrome | |||
| Yes | 0.38 (0.27-0.52) (n = 425) | 10.4 (7.54-15.1) (n = 397) | 3.30 (2.50-5.80) (n = 415) |
| No | 0.29 (0.22-0.42) (n = 1290) | 10.0 (7.08-14.5) (n = 1251) | 2.80 (2.20-4.50) (n = 1309) |
| Unadjusted P value | <.0001 | .06 | <.0001 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| CRP, mg/L | |||
| ≤3 | 0.27 (0.21-0.37) (n = 822) | 10.5 (7.77-14.8) (n = 797) | 2.50 (2.00-3.20) (n = 832) |
| >3 | 0.36 (0.26-0.52) (n = 907) | 9.73 (6.77-14.3) (n = 866) | 3.60 (2.50-6.10) (n = 909) |
| Unadjusted P value | <.0001 | .007 | <.0001 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| CVD risk factor . | γ′ fibrinogen (mg/mL) . | γ′/total fibrinogen ratio (%) . | Total fibrinogen (mg/mL) . |
|---|---|---|---|
| BMI, kg/m2 | |||
| <18.5 | 0.28 (0.20-0.42) (n = 303) | 9.24 (9.06-13.4) (n = 288) | 2.95 (2.20-4.80) (n = 306) |
| 18.5-24.9 | 0.28 (0.21-0.41) (n = 732) | 10.3 (7.19-14.7) (n = 712) | 2.60 (2.10-4.10) (n = 741) |
| 25-29.9 | 0.35 (0.24-0.46) (n = 298) | 10.6 (7.39-15.3) (n = 285) | 2.90 (2.30-5.00) (n = 302) |
| ≥30 | 0.38 (.029-0.56) (n = 345) | 10.4 (7.33-15.1) (n = 327) | 3.70 (2.60-6.20) (n = 338) |
| Unadjusted P value | <.0001 | .001 | <.0001 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| Waist circumference, cm | |||
| Normal | 0.28 (0.21-0.40) (n = 1150) | 9.98 (7.12-14.3) (n = 1112) | 2.60 (2.10-4.10) (n = 1167) |
| Abdominal obesity | 0.38 (0.28-0.53) (n = 605) | 10.4 (7.28-15.2) (n = 574) | 3.30 (2.50-5.90) (n = 559) |
| Unadjusted P value | <.0001 | .067 | <.0001 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| HDL cholesterol, mmol/L | |||
| Normal (≥1.0) | 0.29 (0.22-0.43) (n = 1224) | 9.76 (6.84-14.2) (n = 1175) | 2.80 (2.20-4.80) (n = 1228) |
| Low (<1.0) | 0.35 (0.26-0.51) (n = 514) | 11.1 (8.03-15.3) (n = 496) | 3.00 (2.30-5.50) (n = 521) |
| Unadjusted P value | <.0001 | <.0001 | .009 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| Metabolic syndrome | |||
| Yes | 0.38 (0.27-0.52) (n = 425) | 10.4 (7.54-15.1) (n = 397) | 3.30 (2.50-5.80) (n = 415) |
| No | 0.29 (0.22-0.42) (n = 1290) | 10.0 (7.08-14.5) (n = 1251) | 2.80 (2.20-4.50) (n = 1309) |
| Unadjusted P value | <.0001 | .06 | <.0001 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
| CRP, mg/L | |||
| ≤3 | 0.27 (0.21-0.37) (n = 822) | 10.5 (7.77-14.8) (n = 797) | 2.50 (2.00-3.20) (n = 832) |
| >3 | 0.36 (0.26-0.52) (n = 907) | 9.73 (6.77-14.3) (n = 866) | 3.60 (2.50-6.10) (n = 909) |
| Unadjusted P value | <.0001 | .007 | <.0001 |
| P value adjusted for Fbg | <.0001 | <.0001 | — |
Fbg, fibrinogen.