Impact of follow-up on incidence of complications, rate of hospitalization, and severity of disease
| Variable . | Optimal (n = 80; 69%) . | Suboptimal (n = 28; 24%) . | P . |
|---|---|---|---|
| SMM diagnosis preceding symptomatic MM, n (%) | 24 (30) | 3 (11) | .05* |
| Mechanism of MM diagnosis, n (%) | |||
| Complications | 36 (45) | 7 (25) | .07 |
| Pathologic fracture | 24 (67) | 4 (57) | .7 |
| Severe anemia/pancytopenia | 6 (17) | 2 (29) | .6 |
| Hypercalcemia | 4 (11) | 1 (14) | |
| Acute renal failure | 2 (6) | 0 | .5 |
| Symptoms | 20 (25) | 12 (43) | .09 |
| Follow-up | 13 (16) | 1 (3.5) | .1 |
| Incidental | 9 (11) | 7 (25) | .11 |
| Not available | 2 (3) | 1 (3.5) | NA |
| Diagnosis requiring hospitalization, n (%) | 39 (49) | 11 (39) | .5 |
| Median BM plasma cell percentage at MM diagnosis (range) | 40% (10%-90%) | 41% (7%-95%) | .78 |
| Multiple bone lesions at MM diagnosis, n (%) | 45 (56) | 17 (61) | .47 |
| Durie-Salmon stage III MM, n (%) | 51 (64) | 19 (68) | .8 |
| Variable . | Optimal (n = 80; 69%) . | Suboptimal (n = 28; 24%) . | P . |
|---|---|---|---|
| SMM diagnosis preceding symptomatic MM, n (%) | 24 (30) | 3 (11) | .05* |
| Mechanism of MM diagnosis, n (%) | |||
| Complications | 36 (45) | 7 (25) | .07 |
| Pathologic fracture | 24 (67) | 4 (57) | .7 |
| Severe anemia/pancytopenia | 6 (17) | 2 (29) | .6 |
| Hypercalcemia | 4 (11) | 1 (14) | |
| Acute renal failure | 2 (6) | 0 | .5 |
| Symptoms | 20 (25) | 12 (43) | .09 |
| Follow-up | 13 (16) | 1 (3.5) | .1 |
| Incidental | 9 (11) | 7 (25) | .11 |
| Not available | 2 (3) | 1 (3.5) | NA |
| Diagnosis requiring hospitalization, n (%) | 39 (49) | 11 (39) | .5 |
| Median BM plasma cell percentage at MM diagnosis (range) | 40% (10%-90%) | 41% (7%-95%) | .78 |
| Multiple bone lesions at MM diagnosis, n (%) | 45 (56) | 17 (61) | .47 |
| Durie-Salmon stage III MM, n (%) | 51 (64) | 19 (68) | .8 |
Patients in the optimal category had a statistically significant higher probability to have a diagnosis of SMM preceding the diagnosis of symptomatic MM. Nevertheless, no statistically significant difference between the 2 groups was found in terms of decreased incidence of MM-related complications, MM-related hospitalizations, and disease burden at the time of symptomatic MM diagnosis.
NA indicates not applicable.
Statistically significant.