Genetic loci associated with plasma PAI-1 concentration
| South Asian . | Chinese . | European . | Aboriginal . | Meta-analysis . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Locus . | SNP . | MAF . | β . | P . | MAF . | β . | P . | MAF . | β . | P . | MAF . | β . | P . | β . | P . |
| HABP2 | rs11575741 | < .01 | < .01 | 0.01 | −0.74 | 3.3×10−7 | < .01 | −0.74 | 3.3 × 10−7 | ||||||
| HSPA1A | rs9469058 | .03 | −0.32 | 2.5 × 10−4 | < .01 | 0.03 | −0.14 | .14 | 0.02 | −0.25 | 6.8 × 10−3 | −0.25 | 4.2 × 10−6 | ||
| HYAL1 | rs1283 | < .01 | < .01 | 0.08 | −0.21 | 1.1 × 10−4 | 0.05 | −0.17 | 7.2 × 10−3 | −0.19 | 4.5 × 10−6 | ||||
| MBTPS1 | rs8049209 | .10 | 0.08 | .13 | 0.26 | 0.11 | 1.4 × 10−3 | 0.07 | 0.15 | 8.8 × 10−3 | 0.01 | 0.25 | .069 | −0.21 | 5.2 × 10−6 |
| HYAL1 | rs4855882 | 0.05 | −0.15 | .058 | 0.01 | −0.64 | 1.7 × 10−5 | 0.20 | −0.08 | .046 | 0.07 | −0.05 | .41 | −0.11 | 6.0 × 10−6 |
| TARP | rs3778893 | 0.17 | 0.08 | .067 | 0.15 | 0.08 | .040 | 0.24 | 0.10 | 5.9 × 10−3 | 0.18 | 0.09 | .017 | 0.09 | 7.5 × 10−6 |
| PAI-1 | rs11178 | 0.42 | 0.01 | .66 | 0.46 | 0.04 | .14 | 0.46 | 0.07 | .040 | 0.35 | 0.01 | .82 | 0.05 | .042 |
| PAI-1 | 4G/5G | 0.46 | 0.02 | .49 | 0.45 | −0.05 | .071 | 0.40 | −0.07 | .020 | n/a | n/a | n/a | −0.02 | .051 |
| South Asian . | Chinese . | European . | Aboriginal . | Meta-analysis . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Locus . | SNP . | MAF . | β . | P . | MAF . | β . | P . | MAF . | β . | P . | MAF . | β . | P . | β . | P . |
| HABP2 | rs11575741 | < .01 | < .01 | 0.01 | −0.74 | 3.3×10−7 | < .01 | −0.74 | 3.3 × 10−7 | ||||||
| HSPA1A | rs9469058 | .03 | −0.32 | 2.5 × 10−4 | < .01 | 0.03 | −0.14 | .14 | 0.02 | −0.25 | 6.8 × 10−3 | −0.25 | 4.2 × 10−6 | ||
| HYAL1 | rs1283 | < .01 | < .01 | 0.08 | −0.21 | 1.1 × 10−4 | 0.05 | −0.17 | 7.2 × 10−3 | −0.19 | 4.5 × 10−6 | ||||
| MBTPS1 | rs8049209 | .10 | 0.08 | .13 | 0.26 | 0.11 | 1.4 × 10−3 | 0.07 | 0.15 | 8.8 × 10−3 | 0.01 | 0.25 | .069 | −0.21 | 5.2 × 10−6 |
| HYAL1 | rs4855882 | 0.05 | −0.15 | .058 | 0.01 | −0.64 | 1.7 × 10−5 | 0.20 | −0.08 | .046 | 0.07 | −0.05 | .41 | −0.11 | 6.0 × 10−6 |
| TARP | rs3778893 | 0.17 | 0.08 | .067 | 0.15 | 0.08 | .040 | 0.24 | 0.10 | 5.9 × 10−3 | 0.18 | 0.09 | .017 | 0.09 | 7.5 × 10−6 |
| PAI-1 | rs11178 | 0.42 | 0.01 | .66 | 0.46 | 0.04 | .14 | 0.46 | 0.07 | .040 | 0.35 | 0.01 | .82 | 0.05 | .042 |
| PAI-1 | 4G/5G | 0.46 | 0.02 | .49 | 0.45 | −0.05 | .071 | 0.40 | −0.07 | .020 | n/a | n/a | n/a | −0.02 | .051 |
The result of rs1720119 is not shown due to perfect linkage disequilibrium with rs9469058 in all cohorts.
SNP indicates single nucleotide polymorphism; MAF, minor allele frequency; n/a, not available; HABP2, hyaluronan binding protein 2; HSPA1A, heat shock 70kDa protein 1A; HYAL1, hyaluronoglucosaminidase 1; MBTPS1, membrane-bound transcription factor peptidase, site 1; and TARP, T cell receptor gamma alternate reading frame protein.