Summary of the patient population and PET/CT imaging and immunohistochemical results for the 124I-m11-1F4 study in patients with AL amyloidosis
| AL patient no. . | Age, y/sex . | Affected organ* . | AL isotype . | Free κ/λ, mg/L† . | PET‡ . | IHC (tissue)‡ . |
|---|---|---|---|---|---|---|
| 1 | 60/M | K | κ | 40/54 | 0 | NA |
| 2 | 66/F | LN | λ | 4/125 | LN | + (LN) |
| 3 | 79/F | K | λ | 13/119 | 0 | 0 (K) |
| 4 | 75/F | Lu | λ | 142/97 | 0 | + (Lu) |
| 5 | 63/M | K | λ | 8/287 | 0 | 0 (K) |
| 6 | 74/F | F | λ | 6/264 | 0 | NA |
| 7 | 74/F | H | κ | 252/14 | 0 | + (F) |
| 8 | 73/F | K | λ | 7/195 | I | 0 (K) |
| 9 | 54/F | H, I | κ | 256/2 | L, S | NA |
| 10 | 49/M | T | λ | 2/643 | 0 | 0 (T) |
| 11 | 62/M | L, K, BM | λ | 58/141 | L, S, BM | + (BM) |
| 12 | 57/M | H, L | κ | 67/26 | L, S | + (GB) |
| 13 | 52F | K | λ | 6/52 | L,S | 0 (K) |
| 14 | 57/M | K, L, LN | λ | 1/8 | L, S, BM | ? (LN) |
| 15 | 51/M | H, K | λ | 7/204 | S | + (K) |
| 16 | 66/M | I | λ | 1/15 | 0 | ? (R) |
| 17 | 49/M | K | λ | 12/4871 | S, BM | + (BM) |
| 18 | 57/F | K | λ | 4/31 | 0 | ? (K) |
| AL patient no. . | Age, y/sex . | Affected organ* . | AL isotype . | Free κ/λ, mg/L† . | PET‡ . | IHC (tissue)‡ . |
|---|---|---|---|---|---|---|
| 1 | 60/M | K | κ | 40/54 | 0 | NA |
| 2 | 66/F | LN | λ | 4/125 | LN | + (LN) |
| 3 | 79/F | K | λ | 13/119 | 0 | 0 (K) |
| 4 | 75/F | Lu | λ | 142/97 | 0 | + (Lu) |
| 5 | 63/M | K | λ | 8/287 | 0 | 0 (K) |
| 6 | 74/F | F | λ | 6/264 | 0 | NA |
| 7 | 74/F | H | κ | 252/14 | 0 | + (F) |
| 8 | 73/F | K | λ | 7/195 | I | 0 (K) |
| 9 | 54/F | H, I | κ | 256/2 | L, S | NA |
| 10 | 49/M | T | λ | 2/643 | 0 | 0 (T) |
| 11 | 62/M | L, K, BM | λ | 58/141 | L, S, BM | + (BM) |
| 12 | 57/M | H, L | κ | 67/26 | L, S | + (GB) |
| 13 | 52F | K | λ | 6/52 | L,S | 0 (K) |
| 14 | 57/M | K, L, LN | λ | 1/8 | L, S, BM | ? (LN) |
| 15 | 51/M | H, K | λ | 7/204 | S | + (K) |
| 16 | 66/M | I | λ | 1/15 | 0 | ? (R) |
| 17 | 49/M | K | λ | 12/4871 | S, BM | + (BM) |
| 18 | 57/F | K | λ | 4/31 | 0 | ? (K) |
For affected organ, K indicates kidney; H, heart; L, liver; LN, lymph node; Lu, lung; F, fat only; BM, bone marrow; T, tongue; and I, intestine.
Free κ/λ determined by an enzyme-linked immunosorbent assay (normal range: κ, 4.2-13.0 mg/L; λ, 16.4-127.3 mg/L).14
For PET imaging, 0 indicates no uptake. For immunohistochemistry (IHC), 0 indicates negative immunostain; +, strongly positive immunostain; ?, weakly positive immunostain; BM, bone marrow; I, intestine; S, spleen; GB, gallbladder; L, liver; LN, lymph node; Lu, lung; F, fat only; K, kidney; R, rectum; and NA, tissue not available.