Macrothrombocytopenia in mice doubly homozygous for the Abcg5/Abcg8-targeted mutations
| Genotype . | Platelet number, × 109/L . | MPV, fL . |
|---|---|---|
| (Abcg5/Abcg8)−/− | 335 ± 103* | 14.8 ± 2.1* |
| (Abcg5/Abcg8)+/? | 1201 ± 159 | 5.1 ± 0.4 |
| Genotype . | Platelet number, × 109/L . | MPV, fL . |
|---|---|---|
| (Abcg5/Abcg8)−/− | 335 ± 103* | 14.8 ± 2.1* |
| (Abcg5/Abcg8)+/? | 1201 ± 159 | 5.1 ± 0.4 |
Data are from 4 pairs of targeted mutant (−/−) and heterozygous littermate control mice examined at 5-7 months of age.
(Abcg5/Abcg8)−/− mice significantly different from (Abcg5/Abcg8)+/? controls at P < .01.