Relation of demographic, clinical, and laboratory features and clinical outcomes to ADAMTS13 levels. Continuous data are presented as median values with the minimum and maximum values in parentheses. Severe neurologic abnormalities are defined as coma, stroke, seizure, or focal neurologic signs.⁹  Laboratory data are the most abnormal values at the time of diagnosis, defined as the day of the first plasma exchange treatment, ± 7 days to account for transient changes resulting from transfusion or worsening renal failure.⁹  Acute renal failure is defined as either (1) an increasing serum creatinine (≥ 44.5 μmol/L [≥ 0.5 mg/dL] per day for 2 consecutive days) or (2) serum creatinine ≥ 353.6 μmol/L (≥ 4.0 mg/dL) plus dialysis that began within 7 days of diagnosis.⁹  The number of plasma exchange treatments and the percent of patients with relapse were analyzed only in surviving patients.

BMI indicates body mass index; and LDH, lactate dehydrogenase.

Number in parentheses represents the number of patients who relapsed divided by the number of patients who survived.