Table 2 Overview of CpG site methylation... | American Society of Hematology

Table 2

Overview of CpG site methylation in the ALL samples

	Median methylation (range)		P*	Median methylation (range)		P†
	ALL (n = 401)	Nonleukemic (n = 15)	P*	BCP ALL (n = 341)	T-ALL (n = 60)	P†
All CpG sites (n = 1320)	0.18 (0.04-0.61)	0.12 (0.08-0.13)	< .001	0.17 (0.04-0.46)	0.26 (0.11-0.61)	< .001
Within CpG islands (n = 726)	0.07 (0.02-0.2)	0.05 (0.03-0.05)	< .001	0.07 (0.02-0.2)	0.07 (0.03-0.2)	.320
Outside CpG islands (n = 594)	0.65 (0.34-0.84)	0.59 (0.55-0.63)	< .001	0.64 (0.34-0.84)	0.72 (0.62-0.83)	< .001
Highly variable (n = 300)	0.34 (0.07-0.84)	0.19 (0.14-0.27)	< .001	0.32 (0.07-0.67)	0.54 (0.25-0.84)	< .001

	Median methylation (range)		P*	Median methylation (range)		P†
	ALL (n = 401)	Nonleukemic (n = 15)	P*	BCP ALL (n = 341)	T-ALL (n = 60)	P†
All CpG sites (n = 1320)	0.18 (0.04-0.61)	0.12 (0.08-0.13)	< .001	0.17 (0.04-0.46)	0.26 (0.11-0.61)	< .001
Within CpG islands (n = 726)	0.07 (0.02-0.2)	0.05 (0.03-0.05)	< .001	0.07 (0.02-0.2)	0.07 (0.03-0.2)	.320
Outside CpG islands (n = 594)	0.65 (0.34-0.84)	0.59 (0.55-0.63)	< .001	0.64 (0.34-0.84)	0.72 (0.62-0.83)	< .001
Highly variable (n = 300)	0.34 (0.07-0.84)	0.19 (0.14-0.27)	< .001	0.32 (0.07-0.67)	0.54 (0.25-0.84)	< .001

BCP indicates B-cell precursor ALL.

P value for the difference in median methylation between ALL patients and controls.

P value for the difference in median methylation between BCP ALL patients and T-ALL patients.