Correlation between percent-specific lysis of transformed plasma cells in cytotoxicity assays with the use of autologous CD8+ T cells and percentage of transformed plasma cells stained ex vivo by APM component-specific mAb
| Component . | MGUS . | MM . | ||
|---|---|---|---|---|
| r . | P . | r . | P . | |
| δ | 0.911 | < .001 | 0.261 | .043 |
| MB1 | 0.004 | n.s. | 0.450 | .009 |
| LMP2 | 0.307 | .009 | 0.592 | .006 |
| LMP10 | 0.453 | .025 | 0.651 | .002 |
| TAP1 | 0.267 | n.s | 0.567 | .018 |
| Component . | MGUS . | MM . | ||
|---|---|---|---|---|
| r . | P . | r . | P . | |
| δ | 0.911 | < .001 | 0.261 | .043 |
| MB1 | 0.004 | n.s. | 0.450 | .009 |
| LMP2 | 0.307 | .009 | 0.592 | .006 |
| LMP10 | 0.453 | .025 | 0.651 | .002 |
| TAP1 | 0.267 | n.s | 0.567 | .018 |
APM indicates antigen processing-presenting machinery; mAb, monoclonal antibodies; MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma; and n.s., not significant.
Percentages used for statistical analysis are those shown in Figure 2A,C,E,G,I and Figure 5E (E/T ratio of 20:1) for MGUS and MM patients. Only APM components that had at least 1 significant correlation are shown; Spearman rank test.