Table 1

GO pathway enrichment of gene products differentially regulated by lovastatin exposure as determined by mRNA microarray analysis in 2 or more cell lines

GOEnrichment*
Term
Sensitive
Insensitive†
H929KMS11LP1†SKMM1†
GO:0006066 1.0 2.8 4.8 6.1 Alcohol metabolic process 
GO:0009058 1.2 1.2 2.3 2.8 Biosynthetic process 
GO:0003824 1.1† 1.1 1.4 1.4 Catalytic activity 
GO:0044255 0.8 1.5 3.3 4.9 Cellular lipid metabolic process 
GO:0006695 0.4 20.5 25.2 40.8 Cholesterol biosynthetic process 
GO:0008203 0.7 6.6 11.0 16.6 Cholesterol metabolic process 
GO:0005737 1.2† 1.4 1.3 1.4 Cytoplasm 
GO:0044444 1.1 1.8 1.5 1.8 Cytoplasmic part 
GO:0012505 1.0 1.8 2.0 2.6 Endomembrane system 
GO:0005789 0.9 3.2 2.8 4.3 Endoplasmic reticulum membrane 
GO:0044432 0.9 2.8 2.6 3.8 Endoplasmic reticulum part 
GO:0008299 0.7 17.1 30.5 43.2 Isoprenoid biosynthetic process 
GO:0006720 0.4 10.2 18.3 25.9 Isoprenoid metabolic process 
GO:0008610 1.0 3.1 5.6 8.3 Lipid biosynthetic process 
GO:0006629 0.8 1.2 3.0 4.3 Lipid metabolic process 
GO:0042175 0.9 3.1 2.9 4.2 Nuclear envelope-ER network 
GO:0031090 1.0 1.7 1.7 2.5 Organelle membrane 
GO:0016491 0.7 3.0 2.4 2.9 Oxidoreductase activity 
GO:0006694 0.4 10.7 12.7 20.6 Steroid biosynthetic process 
GO:0008202 0.6 4.7 7.3 11.2 Steroid metabolic process 
GO:0016126 0.3 24.0† 25.0 40.5 Sterol biosynthetic process 
GO:0016125 0.6 9.1 12.3 18.8 Sterol metabolic process 
GOEnrichment*
Term
Sensitive
Insensitive†
H929KMS11LP1†SKMM1†
GO:0006066 1.0 2.8 4.8 6.1 Alcohol metabolic process 
GO:0009058 1.2 1.2 2.3 2.8 Biosynthetic process 
GO:0003824 1.1† 1.1 1.4 1.4 Catalytic activity 
GO:0044255 0.8 1.5 3.3 4.9 Cellular lipid metabolic process 
GO:0006695 0.4 20.5 25.2 40.8 Cholesterol biosynthetic process 
GO:0008203 0.7 6.6 11.0 16.6 Cholesterol metabolic process 
GO:0005737 1.2† 1.4 1.3 1.4 Cytoplasm 
GO:0044444 1.1 1.8 1.5 1.8 Cytoplasmic part 
GO:0012505 1.0 1.8 2.0 2.6 Endomembrane system 
GO:0005789 0.9 3.2 2.8 4.3 Endoplasmic reticulum membrane 
GO:0044432 0.9 2.8 2.6 3.8 Endoplasmic reticulum part 
GO:0008299 0.7 17.1 30.5 43.2 Isoprenoid biosynthetic process 
GO:0006720 0.4 10.2 18.3 25.9 Isoprenoid metabolic process 
GO:0008610 1.0 3.1 5.6 8.3 Lipid biosynthetic process 
GO:0006629 0.8 1.2 3.0 4.3 Lipid metabolic process 
GO:0042175 0.9 3.1 2.9 4.2 Nuclear envelope-ER network 
GO:0031090 1.0 1.7 1.7 2.5 Organelle membrane 
GO:0016491 0.7 3.0 2.4 2.9 Oxidoreductase activity 
GO:0006694 0.4 10.7 12.7 20.6 Steroid biosynthetic process 
GO:0008202 0.6 4.7 7.3 11.2 Steroid metabolic process 
GO:0016126 0.3 24.0† 25.0 40.5 Sterol biosynthetic process 
GO:0016125 0.6 9.1 12.3 18.8 Sterol metabolic process 
*

Enrichment scores denote a fold-change in the number gene products found in each category compared to the number expected by chance alone.

†

Bold values indicate statistically significant enrichment at a false-discovery rate of 10%.

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