Distribution, ORs, and 95% CIs for personal medical history of selected conditions reported by WM patients and their unaffected relatives according to family type and affection status
| Characteristic . | Frequency of reported condition, no. (%) . | OR (95% CI)* . | LRT§ . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases only . | Cases vs controls . | Cases vs controls: all familial WM vs all unaffected . | ||||||||
| Multiple-case WM, n = 57† . | Mixed WM/BCD, n = 46 . | All familial WM, n = 103 . | Unaffected relatives, n = 272 . | Multiple-case WM vs mixed WM/BCD . | Nonfamilial WM vs all familial WM . | Multiple-case WM families . | Mixed WM/BCD families . | |||
| Medical condition | ||||||||||
| Autoimmune disorders | 9 (15.8) | 17 (37.0) | 26 (25.2) | 26 (9.6) | 0.49 (0.18-1.30) | 1.54 (0.60-3.96) | 1.71 (0.62-4.71) | 2.94 (1.41-6.16)‡ | 2.27 (1.21-4.28)‡ | 0.4 |
| Organ-specific¶ | 5 (8.8) | 12 (26.1) | 17 (16.5) | 12 (4.4) | 0.48 (0.15-1.54) | 0.87 (0.23-3.31) | 1.74 (0.52-5.84) | 5.42 (1.67-17.53)‡ | 3.07 (1.29-7.28)‡ | 0.2 |
| Systemic and/or suspected‖ | 4 (7.0) | 7 (15.2) | 11 (10.7) | 16 (5.9) | 0.44 (0.11-1.74) | 1.53 (0.49-4.82) | 1.91 (0.44-8.24) | 2.02 (0.75-5.47) | 1.86 (0.82-4.23) | 1.0 |
| Specific infections** | 19 (33.3) | 18 (39.1) | 37 (35.9) | 59 (21.7) | 0.97 (0.42-2.24) | 1.00 (0.41-2.44) | 2.79 (1.25-6.22)‡ | 1.85 (0.88-3.89) | 2.13 (1.25-3.64)‡ | 0.5 |
| Chronic inflammation†† | 17 (29.8) | 18 (39.1) | 35 (34.0) | 61 (22.4) | 0.74 (0.31-1.77) | 1.46 (0.62-3.46) | 1.19 (0.76-3.61) | 1.65 (0.76-3.60) | 1.58 (0.90-2.80) | 0.5 |
| Allergy | 36 (65.5) | 29 (67.4) | 65 (67.0) | 153 (56.5) | 0.99 (0.38-2.60) | 3.14 (0.72-13.57) | 2.04 (0.84-4.92) | 1.98 (0.96-4.09) | 1.94 (1.09-3.46)‡ | 0.9 |
| Drug | 25 (47.2) | 19 (46.3) | 44 (46.8) | 89 (32.8) | 1.25 (0.50-3.15) | 1.12 (0.42-2.98) | 2.49 (0.89-6.93) | 1.29 (0.61-2.72) | 1.75 (0.94-3.24) | 0.2 |
| Environmental | 20 (36.4) | 15 (35.7) | 35 (36.1) | 98 (36.2) | 0.96 (0.42-2.16) | 1.53 (0.64-3.64) | 1.30 (0.63-2.69) | 1.60 (0.76-3.34) | 1.36 (0.82-2.27) | 0.5 |
| Dietary | 6 (11.1) | 4 (9.5) | 10 (10.4) | 30 (11.0) | 1.22 (0.30-4.90) | 2.02 (0.65-6.24) | 1.11 (0.38-3.21) | 0.94 (0.36-2.45) | 1.02 (0.50-2.11) | 0.9 |
| Surgical procedure | 35 (61.4) | 34 (73.6) | 69 (67.0) | 114 (41.9) | 0.57 (0.23-1.39) | 0.80 (0.32-2.01) | 1.47 (0.65-3.29) | 1.67 (0.79-3.53) | 1.55 (0.88-2.73) | 0.6 |
| Tonsillectomy/adenoidectomy | 25 (43.9) | 27 (58.7) | 52 (50.5) | 95 (34.9) | 0.49 (0.21-1.14) | 1.54 (0.62-3.78) | 1.16 (0.55-2.43) | 0.98 (0.49-1.95) | 1.05 (0.62-1.76) | 0.3 |
| Appendectomy | 17 (29.8) | 12 (26.1) | 29 (28.2) | 45 (16.5) | 1.21 (0.50-2.92) | 0.35 (0.12-1.03) | 1.87 (0.85-4.12) | 0.99 (0.45-2.17) | 1.29 (0.75-2.21) | 0.1 |
| Characteristic . | Frequency of reported condition, no. (%) . | OR (95% CI)* . | LRT§ . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases only . | Cases vs controls . | Cases vs controls: all familial WM vs all unaffected . | ||||||||
| Multiple-case WM, n = 57† . | Mixed WM/BCD, n = 46 . | All familial WM, n = 103 . | Unaffected relatives, n = 272 . | Multiple-case WM vs mixed WM/BCD . | Nonfamilial WM vs all familial WM . | Multiple-case WM families . | Mixed WM/BCD families . | |||
| Medical condition | ||||||||||
| Autoimmune disorders | 9 (15.8) | 17 (37.0) | 26 (25.2) | 26 (9.6) | 0.49 (0.18-1.30) | 1.54 (0.60-3.96) | 1.71 (0.62-4.71) | 2.94 (1.41-6.16)‡ | 2.27 (1.21-4.28)‡ | 0.4 |
| Organ-specific¶ | 5 (8.8) | 12 (26.1) | 17 (16.5) | 12 (4.4) | 0.48 (0.15-1.54) | 0.87 (0.23-3.31) | 1.74 (0.52-5.84) | 5.42 (1.67-17.53)‡ | 3.07 (1.29-7.28)‡ | 0.2 |
| Systemic and/or suspected‖ | 4 (7.0) | 7 (15.2) | 11 (10.7) | 16 (5.9) | 0.44 (0.11-1.74) | 1.53 (0.49-4.82) | 1.91 (0.44-8.24) | 2.02 (0.75-5.47) | 1.86 (0.82-4.23) | 1.0 |
| Specific infections** | 19 (33.3) | 18 (39.1) | 37 (35.9) | 59 (21.7) | 0.97 (0.42-2.24) | 1.00 (0.41-2.44) | 2.79 (1.25-6.22)‡ | 1.85 (0.88-3.89) | 2.13 (1.25-3.64)‡ | 0.5 |
| Chronic inflammation†† | 17 (29.8) | 18 (39.1) | 35 (34.0) | 61 (22.4) | 0.74 (0.31-1.77) | 1.46 (0.62-3.46) | 1.19 (0.76-3.61) | 1.65 (0.76-3.60) | 1.58 (0.90-2.80) | 0.5 |
| Allergy | 36 (65.5) | 29 (67.4) | 65 (67.0) | 153 (56.5) | 0.99 (0.38-2.60) | 3.14 (0.72-13.57) | 2.04 (0.84-4.92) | 1.98 (0.96-4.09) | 1.94 (1.09-3.46)‡ | 0.9 |
| Drug | 25 (47.2) | 19 (46.3) | 44 (46.8) | 89 (32.8) | 1.25 (0.50-3.15) | 1.12 (0.42-2.98) | 2.49 (0.89-6.93) | 1.29 (0.61-2.72) | 1.75 (0.94-3.24) | 0.2 |
| Environmental | 20 (36.4) | 15 (35.7) | 35 (36.1) | 98 (36.2) | 0.96 (0.42-2.16) | 1.53 (0.64-3.64) | 1.30 (0.63-2.69) | 1.60 (0.76-3.34) | 1.36 (0.82-2.27) | 0.5 |
| Dietary | 6 (11.1) | 4 (9.5) | 10 (10.4) | 30 (11.0) | 1.22 (0.30-4.90) | 2.02 (0.65-6.24) | 1.11 (0.38-3.21) | 0.94 (0.36-2.45) | 1.02 (0.50-2.11) | 0.9 |
| Surgical procedure | 35 (61.4) | 34 (73.6) | 69 (67.0) | 114 (41.9) | 0.57 (0.23-1.39) | 0.80 (0.32-2.01) | 1.47 (0.65-3.29) | 1.67 (0.79-3.53) | 1.55 (0.88-2.73) | 0.6 |
| Tonsillectomy/adenoidectomy | 25 (43.9) | 27 (58.7) | 52 (50.5) | 95 (34.9) | 0.49 (0.21-1.14) | 1.54 (0.62-3.78) | 1.16 (0.55-2.43) | 0.98 (0.49-1.95) | 1.05 (0.62-1.76) | 0.3 |
| Appendectomy | 17 (29.8) | 12 (26.1) | 29 (28.2) | 45 (16.5) | 1.21 (0.50-2.92) | 0.35 (0.12-1.03) | 1.87 (0.85-4.12) | 0.99 (0.45-2.17) | 1.29 (0.75-2.21) | 0.1 |
OR indicates odds ratio; CI, confidence interval; WM, Waldenström macroglobulinemia; BCD, B-cell disorder; and LRT, likelihood ratio test.
Accounting for familial clustering among relatives and adjusted for age, sex, and family type (in all familial WM models).
Numbers and percentages may not sum to total because of missing data and rounding, respectively. Percentages are based on nonmissing values.
Parameters that differed significantly (P < .05) between groups. See “Results.”
Likelihood ratio test (LRT) performed for case-versus-control analyses.
Includes report of thyroiditis, Grave disease, hemolytic anemia, pernicious anemia, thrombocytopenic purpura, and multiple sclerosis.
Includes report of Sjögren syndrome, rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, systemic sclerosis, psoriasis, celiac disease, polymyalgia rheumatica, and rheumatic fever.
Includes report of hepatitis, mononucleosis, osteomyelitis, pneumonia requiring hospitalization, pyelonephritis, and tuberculosis.
Includes report of asthma, chronic cholecystitis, chronic hepatitis, chronic sinusitis, and chronic bronchitis.