Selection of pathways differentially expressed in NKTCL tissues compared to normal NK cells or PTCL, NOS
| Pathway name . | Median P value, compared with normal NK cells* . | Median P value, compared with PTCL, NOS* . |
|---|---|---|
| Apoptosis | ||
| Apoptosis | .002 | < .002 |
| Regulation of BAD phosphorylation | .109 | < .018 |
| PTEN-dependent cell-cycle arrest and apoptosis | .246 | < .015 |
| FAS signaling pathway | .257 | < .006 |
| Cytotoxicity | ||
| NK cell–mediated cytotoxicity | .002 | < .0001 |
| Ras-independent pathway in NK cell–mediated cytotoxicity | .325 | < .0001 |
| Cell adhesion molecules/extracellular matrix receptor interaction | ||
| Cell communication | .001 | < .016 |
| ECM receptor interaction | .001 | < .016 |
| Focal adhesion | .001 | < .023 |
| Cell adhesion molecules | .002 | < .012 |
| Leukocyte transendothelial migration | .002 | .371 |
| Inhibition of matrix metalloproteinases | .003 | .018 |
| Integrin signaling pathway | .003 | .484 |
| Cell cycle | ||
| Regulation of p27 during phosphorylation | < .006 | .008 |
| Cyclin E destruction pathway | < .041 | .003 |
| Chemokines/cytokines | ||
| Cytokine cytokine receptor interaction | .002 | < .001 |
| Signal transduction | ||
| JAK-STAT signaling pathway | .002 | .01 |
| MAPK signaling pathway | .002 | .015 |
| mTOR signaling pathway | .002 | .06 |
| NF-κB signaling pathway | .002 | .06 |
| TGFβ signaling pathway | .002 | .019 |
| VEGF signaling pathway | .002 | .418 |
| Notch signaling pathway | < .005 | .025 |
| Wnt signaling pathway | < .005 | < .013 |
| AKT signaling pathway | .14 | < .001 |
| Pathway name . | Median P value, compared with normal NK cells* . | Median P value, compared with PTCL, NOS* . |
|---|---|---|
| Apoptosis | ||
| Apoptosis | .002 | < .002 |
| Regulation of BAD phosphorylation | .109 | < .018 |
| PTEN-dependent cell-cycle arrest and apoptosis | .246 | < .015 |
| FAS signaling pathway | .257 | < .006 |
| Cytotoxicity | ||
| NK cell–mediated cytotoxicity | .002 | < .0001 |
| Ras-independent pathway in NK cell–mediated cytotoxicity | .325 | < .0001 |
| Cell adhesion molecules/extracellular matrix receptor interaction | ||
| Cell communication | .001 | < .016 |
| ECM receptor interaction | .001 | < .016 |
| Focal adhesion | .001 | < .023 |
| Cell adhesion molecules | .002 | < .012 |
| Leukocyte transendothelial migration | .002 | .371 |
| Inhibition of matrix metalloproteinases | .003 | .018 |
| Integrin signaling pathway | .003 | .484 |
| Cell cycle | ||
| Regulation of p27 during phosphorylation | < .006 | .008 |
| Cyclin E destruction pathway | < .041 | .003 |
| Chemokines/cytokines | ||
| Cytokine cytokine receptor interaction | .002 | < .001 |
| Signal transduction | ||
| JAK-STAT signaling pathway | .002 | .01 |
| MAPK signaling pathway | .002 | .015 |
| mTOR signaling pathway | .002 | .06 |
| NF-κB signaling pathway | .002 | .06 |
| TGFβ signaling pathway | .002 | .019 |
| VEGF signaling pathway | .002 | .418 |
| Notch signaling pathway | < .005 | .025 |
| Wnt signaling pathway | < .005 | < .013 |
| AKT signaling pathway | .14 | < .001 |
With a median P value < .02 compared to either normal NK cells or PTCL, NOS.