Copy number alterations identified by aCGH in the NKTCL samples analyzed in this study
| Chromosomes . | Start position, Mb . | End position, Mb . | No. of clones . | NKTCL tissues and cell lines (n=10) . | NKTCL tissues (n=8) . | SNK6 . | SNT8 . |
|---|---|---|---|---|---|---|---|
| Gain | |||||||
| 1q21-q44 | 143 | 245 | 170 | 5 | 3 | 1 | 1 |
| 4p16 | 2 | 6 | 5 | 3 | 3 | 0 | 0 |
| 6p25-p11.1 | 0 | 58 | 93 | 4 | 3 | 1 | 0 |
| 6q11.1-q14 | 58 | 87 | 26 | 4 | 3 | 1 | 0 |
| 6q27 | 167 | 171 | 5 | 3 | 3 | 0 | 0 |
| 7p12-p11.2 | 53 | 55 | 4 | 5 | 4 | 0 | 1 |
| 7q11.2-q34 | 62 | 142 | 99 | 5 | 4 | 1 | 0 |
| 7q35-q36 | 143 | 156 | 11 | 6 | 5 | 1 | 0 |
| 8p23.3 | 0.13 | 1.96 | 5 | 4 | 3 | 1 | 0 |
| 9q34 | 134 | 138 | 7 | 4 | 3 | 1 | 0 |
| 10p15 | 0 | 4 | 5 | 6 | 6 | 0 | 0 |
| 10p15-p14 | 6 | 8 | 6 | 3 | 3 | 0 | 0 |
| 11p15 | 0 | 3 | 10 | 4 | 3 | 1 | 0 |
| 16p13.3 | 1 | 2 | 5 | 4 | 4 | 0 | 0 |
| 17q12 | 28.81 | 30.78 | 12 | 5 | 3 | 1 | 1 |
| 17q12 | 29.84 | 30.30 | 7 | 6 | 4 | 1 | 1 |
| 22q11.21 | 16.15 | 21.17 | 6 | 4 | 3 | 0 | 1 |
| Loss | |||||||
| 6q16-q25 | 100 | 154 | 75 | 4 | 3 | 1 | 0 |
| 8p23-p22 | 4 | 15 | 14 | 3 | 3 | 0 | 0 |
| 11q24-q25 | 128 | 133 | 8 | 4 | 3 | 0 | 1 |
| 17p13.3 | 0.34 | 0.96 | 6 | 4 | 3 | 1 | 0 |
| Chromosomes . | Start position, Mb . | End position, Mb . | No. of clones . | NKTCL tissues and cell lines (n=10) . | NKTCL tissues (n=8) . | SNK6 . | SNT8 . |
|---|---|---|---|---|---|---|---|
| Gain | |||||||
| 1q21-q44 | 143 | 245 | 170 | 5 | 3 | 1 | 1 |
| 4p16 | 2 | 6 | 5 | 3 | 3 | 0 | 0 |
| 6p25-p11.1 | 0 | 58 | 93 | 4 | 3 | 1 | 0 |
| 6q11.1-q14 | 58 | 87 | 26 | 4 | 3 | 1 | 0 |
| 6q27 | 167 | 171 | 5 | 3 | 3 | 0 | 0 |
| 7p12-p11.2 | 53 | 55 | 4 | 5 | 4 | 0 | 1 |
| 7q11.2-q34 | 62 | 142 | 99 | 5 | 4 | 1 | 0 |
| 7q35-q36 | 143 | 156 | 11 | 6 | 5 | 1 | 0 |
| 8p23.3 | 0.13 | 1.96 | 5 | 4 | 3 | 1 | 0 |
| 9q34 | 134 | 138 | 7 | 4 | 3 | 1 | 0 |
| 10p15 | 0 | 4 | 5 | 6 | 6 | 0 | 0 |
| 10p15-p14 | 6 | 8 | 6 | 3 | 3 | 0 | 0 |
| 11p15 | 0 | 3 | 10 | 4 | 3 | 1 | 0 |
| 16p13.3 | 1 | 2 | 5 | 4 | 4 | 0 | 0 |
| 17q12 | 28.81 | 30.78 | 12 | 5 | 3 | 1 | 1 |
| 17q12 | 29.84 | 30.30 | 7 | 6 | 4 | 1 | 1 |
| 22q11.21 | 16.15 | 21.17 | 6 | 4 | 3 | 0 | 1 |
| Loss | |||||||
| 6q16-q25 | 100 | 154 | 75 | 4 | 3 | 1 | 0 |
| 8p23-p22 | 4 | 15 | 14 | 3 | 3 | 0 | 0 |
| 11q24-q25 | 128 | 133 | 8 | 4 | 3 | 0 | 1 |
| 17p13.3 | 0.34 | 0.96 | 6 | 4 | 3 | 1 | 0 |