Selection of genes overexpressed in NKTCL tissues compared to PTCL, NOS cells with P < .005
| Gene class and specific genes . | Fold change . |
|---|---|
| Apoptosis | |
| BCL2L2 (BCL-W) | 1.68 |
| FASLG (Fas ligand) | 5.99 |
| Cell-to-cell interactions | |
| ITGAM (Integrin, alpha M) | 2.30 |
| Chemokines | |
| CCL4 (MIP-1-beta) | 4.30 |
| CCL5 (RANTES) | 8.66 |
| Cytokines and receptors | |
| IL20 | 1.15 |
| IL2RB | 2.32 |
| Growth factors | |
| TGFB2 | 1.14 |
| Cytotoxic molecules | |
| CTSW (Cathepsin W) | 11.31 |
| GZMA (Granzyme A) | 8.03 |
| GZMB (Granzyme B) | 5.39 |
| GZMH (Granzyme H) | 13.66 |
| PRF1 (Perforin 1) | 3.34 |
| NK cell–associated molecules | |
| APOBEC3G (Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G) | 2.40 |
| CD244 (NK-cell receptor 2B4) | 6.75 |
| KIR2DL3 /// KIR2DS5 | 10.30 |
| KIR2DL4 | 11.77 |
| KIR2DL5A | 7.47 |
| KIR2DS4 | 4.94 |
| KIR3DL1 | 9.96 |
| KIR3DL2 | 14.02 |
| KIR3DL3 | 12.51 |
| KLRC1 /// KLRC2 | 25.75 |
| KLRC3 | 32.96 |
| KLRC4 /// KLRK1 | 10.33 |
| KLRD1 | 32.45 |
| NCAM1 (CD56) | 10.54 |
| Immune responses | |
| IRF6 (Interferon regulatory factor 6) | 1.54 |
| Oncogenes | |
| MYC | 1.18 |
| RHOC (Ras homolog gene family, member C) | 3.22 |
| Transcription factors | |
| ATF6 (Activating transcription factor 6) | 1.39 |
| Miscellaneous | |
| MAPK1 | 1.46 |
| PTPN22 (Protein tyrosine phosphatase, nonreceptor type 22) | 2.47 |
| YWHAH (Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide) | 1.62 |
| Gene class and specific genes . | Fold change . |
|---|---|
| Apoptosis | |
| BCL2L2 (BCL-W) | 1.68 |
| FASLG (Fas ligand) | 5.99 |
| Cell-to-cell interactions | |
| ITGAM (Integrin, alpha M) | 2.30 |
| Chemokines | |
| CCL4 (MIP-1-beta) | 4.30 |
| CCL5 (RANTES) | 8.66 |
| Cytokines and receptors | |
| IL20 | 1.15 |
| IL2RB | 2.32 |
| Growth factors | |
| TGFB2 | 1.14 |
| Cytotoxic molecules | |
| CTSW (Cathepsin W) | 11.31 |
| GZMA (Granzyme A) | 8.03 |
| GZMB (Granzyme B) | 5.39 |
| GZMH (Granzyme H) | 13.66 |
| PRF1 (Perforin 1) | 3.34 |
| NK cell–associated molecules | |
| APOBEC3G (Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G) | 2.40 |
| CD244 (NK-cell receptor 2B4) | 6.75 |
| KIR2DL3 /// KIR2DS5 | 10.30 |
| KIR2DL4 | 11.77 |
| KIR2DL5A | 7.47 |
| KIR2DS4 | 4.94 |
| KIR3DL1 | 9.96 |
| KIR3DL2 | 14.02 |
| KIR3DL3 | 12.51 |
| KLRC1 /// KLRC2 | 25.75 |
| KLRC3 | 32.96 |
| KLRC4 /// KLRK1 | 10.33 |
| KLRD1 | 32.45 |
| NCAM1 (CD56) | 10.54 |
| Immune responses | |
| IRF6 (Interferon regulatory factor 6) | 1.54 |
| Oncogenes | |
| MYC | 1.18 |
| RHOC (Ras homolog gene family, member C) | 3.22 |
| Transcription factors | |
| ATF6 (Activating transcription factor 6) | 1.39 |
| Miscellaneous | |
| MAPK1 | 1.46 |
| PTPN22 (Protein tyrosine phosphatase, nonreceptor type 22) | 2.47 |
| YWHAH (Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide) | 1.62 |
A complete list of genes is given in supplementary Table 2.