Selection of genes overexpressed in NKTCL tissues compared to normal NK cells with P < .005
| Gene class and specific genes . | Fold change . |
|---|---|
| Cell-to-cell interactions | |
| CDH1 (E-cadherin)* | 1.54 |
| ITGA9 (Integrin alpha 9) | 2.37 |
| ITGB4 (Integrin beta 4)* | 2.15 |
| VCAM1 (Vascular cell adhesion molecule 1)* | 26.18 |
| Cell-cycle control | |
| CCND1 (Cyclin D1)* | 6.67 |
| Chemokines | |
| CCL18 | 10.50 |
| CCL19 | 80.67 |
| CCL2* | 88.11 |
| CCL8* | 51.61 |
| CXCL10 (IP10)* | 48.07 |
| CXCL12 (SDF-1) | 25.75 |
| CXCL9 (Mig) | 254.14 |
| Cytokines | |
| IL13RA1* | 9.19 |
| IL6R | 2.25 |
| IL33* | 2.75 |
| IL8* | 5.07 |
| Genes overexpressed in EBV-infected lymphoma cell lines | |
| EBI3 (EBV-induced gene 3)* | 2.76 |
| BASP1 (Brain abundant, membrane-attached signal protein 1)* | 13.21 |
| HCK (Hemopoietic cell kinase) | 16.01 |
| TNFRSF10D (Tumor necrosis factor receptor superfamily, member 10d)* | 1.53 |
| Extracellular matrix interactions | |
| COL1A1 (Collagen, type I alpha 1)* | 45.91 |
| COL1A2 (Collagen, type I alpha 2)* | 33.35 |
| COL3A1 (Collagen, type III alpha 1)* | 59.68 |
| FN1 (Fibronectin 1)* | 91.79 |
| TIMP1 (TIMP metallopeptidase inhibitor 1)* | 6.28 |
| TIMP2 (TIMP metallopeptidase inhibitor 2) | 10.79 |
| TIMP3 (TIMP metallopeptidase inhibitor 3) | 9.57 |
| Growth factors and receptors | |
| GHR (Growth hormone receptor)* | 1.35 |
| PDGFB (Platelet-derived growth factor beta)* | 2.16 |
| PDGFC (Platelet derived growth factor C)* | 7.92 |
| PDGFRA (Platelet-derived growth factor receptor, alpha polypeptide)* | 7.47 |
| Immunity and lymphocyte development | |
| CD86* | 6.04 |
| HLA-DOA* | 12.12 |
| HLA-DRA* | 12.18 |
| IL4I1 (Interleukin 4–induced 1)* | 6.40 |
| SLAMF8 (SLAM family member 8)* | 45.26 |
| TLR2 | 8.76 |
| TLR7* | 5.26 |
| TLR8 | 13.49 |
| Microenvironment | |
| CD163 | 134.47 |
| Oncogenes | |
| MAFB (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) | 37.94 |
| MET (Hepatocyte growth factor receptor)* | 2.00 |
| MYC* | 1.23 |
| Transcription factors | |
| STAT1* | 5.25 |
| STAT2* | 1.86 |
| Vascular biology | |
| KDR (VEGFR2)* | 1.47 |
| THBD (Thrombomodulin) | 4.33 |
| VEGFA* | 1.54 |
| VEGFC* | 1.68 |
| VWF* | 12.97 |
| Miscellaneous | |
| AIM2 (Absent in melanoma 2)* | 14.76 |
| CD40 (TNF receptor superfamily member 5)* | 3.95 |
| FZD1 (Frizzled homolog 1)* | 2.55 |
| Gene class and specific genes . | Fold change . |
|---|---|
| Cell-to-cell interactions | |
| CDH1 (E-cadherin)* | 1.54 |
| ITGA9 (Integrin alpha 9) | 2.37 |
| ITGB4 (Integrin beta 4)* | 2.15 |
| VCAM1 (Vascular cell adhesion molecule 1)* | 26.18 |
| Cell-cycle control | |
| CCND1 (Cyclin D1)* | 6.67 |
| Chemokines | |
| CCL18 | 10.50 |
| CCL19 | 80.67 |
| CCL2* | 88.11 |
| CCL8* | 51.61 |
| CXCL10 (IP10)* | 48.07 |
| CXCL12 (SDF-1) | 25.75 |
| CXCL9 (Mig) | 254.14 |
| Cytokines | |
| IL13RA1* | 9.19 |
| IL6R | 2.25 |
| IL33* | 2.75 |
| IL8* | 5.07 |
| Genes overexpressed in EBV-infected lymphoma cell lines | |
| EBI3 (EBV-induced gene 3)* | 2.76 |
| BASP1 (Brain abundant, membrane-attached signal protein 1)* | 13.21 |
| HCK (Hemopoietic cell kinase) | 16.01 |
| TNFRSF10D (Tumor necrosis factor receptor superfamily, member 10d)* | 1.53 |
| Extracellular matrix interactions | |
| COL1A1 (Collagen, type I alpha 1)* | 45.91 |
| COL1A2 (Collagen, type I alpha 2)* | 33.35 |
| COL3A1 (Collagen, type III alpha 1)* | 59.68 |
| FN1 (Fibronectin 1)* | 91.79 |
| TIMP1 (TIMP metallopeptidase inhibitor 1)* | 6.28 |
| TIMP2 (TIMP metallopeptidase inhibitor 2) | 10.79 |
| TIMP3 (TIMP metallopeptidase inhibitor 3) | 9.57 |
| Growth factors and receptors | |
| GHR (Growth hormone receptor)* | 1.35 |
| PDGFB (Platelet-derived growth factor beta)* | 2.16 |
| PDGFC (Platelet derived growth factor C)* | 7.92 |
| PDGFRA (Platelet-derived growth factor receptor, alpha polypeptide)* | 7.47 |
| Immunity and lymphocyte development | |
| CD86* | 6.04 |
| HLA-DOA* | 12.12 |
| HLA-DRA* | 12.18 |
| IL4I1 (Interleukin 4–induced 1)* | 6.40 |
| SLAMF8 (SLAM family member 8)* | 45.26 |
| TLR2 | 8.76 |
| TLR7* | 5.26 |
| TLR8 | 13.49 |
| Microenvironment | |
| CD163 | 134.47 |
| Oncogenes | |
| MAFB (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) | 37.94 |
| MET (Hepatocyte growth factor receptor)* | 2.00 |
| MYC* | 1.23 |
| Transcription factors | |
| STAT1* | 5.25 |
| STAT2* | 1.86 |
| Vascular biology | |
| KDR (VEGFR2)* | 1.47 |
| THBD (Thrombomodulin) | 4.33 |
| VEGFA* | 1.54 |
| VEGFC* | 1.68 |
| VWF* | 12.97 |
| Miscellaneous | |
| AIM2 (Absent in melanoma 2)* | 14.76 |
| CD40 (TNF receptor superfamily member 5)* | 3.95 |
| FZD1 (Frizzled homolog 1)* | 2.55 |
A complete list of genes is given in supplementary Table 1.
Genes are also overexpressed in NKTCL cell lines compared to normal NK cells.