Table 4 Multivariate analyses of 3-year... | American Society of Hematology

Table 4

Multivariate analyses of 3-year survival end points

Variable	n	RR (95% Confidence interval)	P
Transplant-related mortality
0-MM	56	0.4 (0.2-0.9)	.019*
1-MM > 5.0 × 10⁷/kg	155	0.8 (0.6-1.3)	.391
2-MM > 5.0 × 10⁷/kg	212	1.0 (0.7-1.5)	.847
1-MM 2.5-4.9 × 10⁷/kg	130	Reference
2-MM 2.5-4.9 × 10⁷/kg	240	1.5 (1.1-2.1)	.014*
1-MM < 2.5 × 10⁷/kg	67	1.9 (1.3-2.9)	.002*
2-MM < 2.5.0 × 10⁷/kg	136	2.4 (1.7-3.4)	< .001*
3-MM	65	1.7 (1.1-2.6)	.020*
Transplant-related mortality (engrafted patients only)
0-MM	47	0.5 (0.2-1.1)	.072
1-MM > 5.0 × 10⁷/kg	120	0.8 (0.5-1.4)	.518
2-MM > 5.0 × 10⁷/kg	165	1.2 (0.8-1.9)	.452
1-MM 2.5-4.9 × 10⁷/kg	94	Reference
2-MM 2.5-4.9 × 10⁷/kg	171	1.6 (1.0-2.5)	.032*
1-MM < 2.5 × 10⁷/kg	40	1.9 (1.1-3.3)	.029*
2-MM < 2.5.0 × 10⁷/kg	81	2.3 (1.4-3.7)	.001*
3-MM	45	2.1 (1.2-3.6)	.011*
Overall mortality
0-MM	56	0.5 (0.3-0.8)	.005*
1-MM > 5.0 × 10⁷/kg	155	0.8 (0.6-1.2)	.295
2-MM > 5.0 × 10⁷/kg	212	1.0 (0.7-1.3)	.769
1-MM 2.5-4.9 × 10⁷/kg	130	Reference
2-MM 2.5-4.9 × 10⁷/kg	240	1.2 (0.9-1.6)	.195
1-MM < 2.5 × 10⁷/kg	67	1.6 (1.1-2.2)	.013*
2-MM < 2.5.0 × 10⁷/kg	136	1.8 (1.3-2.4)	< .001*
3-MM	65	1.4 (1.0-2.1)	.048*
Treatment failure (reciprocal of disease-free survival)
0-MM	56	0.5 (0.3-0.9)	.011*
1-MM > 5.0 × 10⁷/kg	155	0.9 (0.7-1.3)	.693
2-MM > 5.0 × 10⁷/kg	212	1.0 (0.8-1.4)	.822
1-MM 2.5-4.9 × 10⁷/kg	130	Reference
2-MM 2.5-4.9 × 10⁷/kg	240	1.2 (0.9-1.6)	.120
1-MM < 2.5 × 10⁷/kg	67	1.5 (1.1-2.2)	.018*
2-MM < 2.5.0 × 10⁷/kg	136	1.7 (1.3-2.3)	< .001*
3-MM	65	1.5 (1.0-2.1)	.039*

Variable	n	RR (95% Confidence interval)	P
Transplant-related mortality
0-MM	56	0.4 (0.2-0.9)	.019*
1-MM > 5.0 × 10⁷/kg	155	0.8 (0.6-1.3)	.391
2-MM > 5.0 × 10⁷/kg	212	1.0 (0.7-1.5)	.847
1-MM 2.5-4.9 × 10⁷/kg	130	Reference
2-MM 2.5-4.9 × 10⁷/kg	240	1.5 (1.1-2.1)	.014*
1-MM < 2.5 × 10⁷/kg	67	1.9 (1.3-2.9)	.002*
2-MM < 2.5.0 × 10⁷/kg	136	2.4 (1.7-3.4)	< .001*
3-MM	65	1.7 (1.1-2.6)	.020*
Transplant-related mortality (engrafted patients only)
0-MM	47	0.5 (0.2-1.1)	.072
1-MM > 5.0 × 10⁷/kg	120	0.8 (0.5-1.4)	.518
2-MM > 5.0 × 10⁷/kg	165	1.2 (0.8-1.9)	.452
1-MM 2.5-4.9 × 10⁷/kg	94	Reference
2-MM 2.5-4.9 × 10⁷/kg	171	1.6 (1.0-2.5)	.032*
1-MM < 2.5 × 10⁷/kg	40	1.9 (1.1-3.3)	.029*
2-MM < 2.5.0 × 10⁷/kg	81	2.3 (1.4-3.7)	.001*
3-MM	45	2.1 (1.2-3.6)	.011*
Overall mortality
0-MM	56	0.5 (0.3-0.8)	.005*
1-MM > 5.0 × 10⁷/kg	155	0.8 (0.6-1.2)	.295
2-MM > 5.0 × 10⁷/kg	212	1.0 (0.7-1.3)	.769
1-MM 2.5-4.9 × 10⁷/kg	130	Reference
2-MM 2.5-4.9 × 10⁷/kg	240	1.2 (0.9-1.6)	.195
1-MM < 2.5 × 10⁷/kg	67	1.6 (1.1-2.2)	.013*
2-MM < 2.5.0 × 10⁷/kg	136	1.8 (1.3-2.4)	< .001*
3-MM	65	1.4 (1.0-2.1)	.048*
Treatment failure (reciprocal of disease-free survival)
0-MM	56	0.5 (0.3-0.9)	.011*
1-MM > 5.0 × 10⁷/kg	155	0.9 (0.7-1.3)	.693
2-MM > 5.0 × 10⁷/kg	212	1.0 (0.8-1.4)	.822
1-MM 2.5-4.9 × 10⁷/kg	130	Reference
2-MM 2.5-4.9 × 10⁷/kg	240	1.2 (0.9-1.6)	.120
1-MM < 2.5 × 10⁷/kg	67	1.5 (1.1-2.2)	.018*
2-MM < 2.5.0 × 10⁷/kg	136	1.7 (1.3-2.3)	< .001*
3-MM	65	1.5 (1.0-2.1)	.039*

CBT indicates cord blood transplant; CMV, cytomegalovirus; MM, mismatch; RR, relative risk; TNC, total nucleated cells; TRM, transplant-related mortality; and US, United States.

Other predictive variables, such as white patient ancestry, recipient seronegativity for CMV, US transplant centers with greater experience, and more recent year of transplantation (2003-2006), were associated with lower TRM, treatment failure, and mortality. High-risk leukemia was associated with a worse outcome for these end points.

Statistically significant P value.

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