Intravenous busulfan pharmacokinetic data
| . | Day 1 . | Day 2 . | Day 3 . | Day 4 . |
|---|---|---|---|---|
| No. of evaluable patients | 71 | 71 | 71 | 69 |
| Bu AUC, μMol*/min | ||||
| Mean ± SD | 996 ± 213 | 1210 ± 201 | 1234 ± 176 | 1210 ± 138 |
| Median (range) | 971 (630-1621) | 1202 (746-1664) | 1219 (845-1700) | 1193 (855-1709) |
| Percentage coefficient of variation | 21.4 | 16.6 | 14.3 | 11.4 |
| Bu concentration (Css), ng/mL | ||||
| Mean ± SD | 682 ± 146 | 828 ± 137 | 844 ± 121 | 828 ± 94 |
| Median (range) | 664 (431-1109) | 822 (510-1138) | 830 (578-1163) | 816 (585-1169) |
| Percentage coefficient of variation | 21.4 | 16.6 | 14.3 | 11.4 |
| Bu clearance, mL/min per kilogram | ||||
| Mean ± SD | 4.15 ± 0.87 | 3.62 ± 0.80 | 3.71 ± 0.75 | 3.41 ± 0.78 |
| Median (range) | 4.10 (2.38-6.19) | 3.55 (2.08-5.75) | 3.30 (1.93-5.50) | 3.36 (1.8-5.58) |
| Percentage coefficient of variation | 30.0 | 22.1 | 20.2 | 22.8 |
| T1/2, hours | ||||
| Mean ± SD | 1.85 ± 0.23 | 2.13 ± 0.28 | 2.26 ± 0.30 | 2.27 ± 0.33 |
| Median (range) | 1.83 (1.2-2.48) | 2.1 (1.43-3.06) | 2.25 (1.33-3.08) | 2.24 (1.42-3.28) |
| Percentage coefficient of variation | 12.4 | 13.2 | 13.3 | 14.5 |
| . | Day 1 . | Day 2 . | Day 3 . | Day 4 . |
|---|---|---|---|---|
| No. of evaluable patients | 71 | 71 | 71 | 69 |
| Bu AUC, μMol*/min | ||||
| Mean ± SD | 996 ± 213 | 1210 ± 201 | 1234 ± 176 | 1210 ± 138 |
| Median (range) | 971 (630-1621) | 1202 (746-1664) | 1219 (845-1700) | 1193 (855-1709) |
| Percentage coefficient of variation | 21.4 | 16.6 | 14.3 | 11.4 |
| Bu concentration (Css), ng/mL | ||||
| Mean ± SD | 682 ± 146 | 828 ± 137 | 844 ± 121 | 828 ± 94 |
| Median (range) | 664 (431-1109) | 822 (510-1138) | 830 (578-1163) | 816 (585-1169) |
| Percentage coefficient of variation | 21.4 | 16.6 | 14.3 | 11.4 |
| Bu clearance, mL/min per kilogram | ||||
| Mean ± SD | 4.15 ± 0.87 | 3.62 ± 0.80 | 3.71 ± 0.75 | 3.41 ± 0.78 |
| Median (range) | 4.10 (2.38-6.19) | 3.55 (2.08-5.75) | 3.30 (1.93-5.50) | 3.36 (1.8-5.58) |
| Percentage coefficient of variation | 30.0 | 22.1 | 20.2 | 22.8 |
| T1/2, hours | ||||
| Mean ± SD | 1.85 ± 0.23 | 2.13 ± 0.28 | 2.26 ± 0.30 | 2.27 ± 0.33 |
| Median (range) | 1.83 (1.2-2.48) | 2.1 (1.43-3.06) | 2.25 (1.33-3.08) | 2.24 (1.42-3.28) |
| Percentage coefficient of variation | 12.4 | 13.2 | 13.3 | 14.5 |