Recorded side effects of CEP-701 therapy
| Toxicity . | No. (%) of patients . | ||
|---|---|---|---|
| Any grade . | Grade 3 or 4 . | ||
| Hematologic | |||
| Anemia | 6 (27) | 3 (14) | |
| Thrombocytopenia | 5 (23) | 5 (23) | |
| Nonhematologic | |||
| Diarrhea | 16 (73) | 2 (9) | |
| Nausea | 11 (50) | — | |
| Headache | 7 (32) | — | |
| Vomiting | 6 (27) | — | |
| Flatulence | 5 (23) | — | |
| Heartburn | 4 (18) | — | |
| Mucositis | 3 (14) | — | |
| Peripheral neuropathy | 3 (14) | — | |
| Anorexia | 2 (9) | — | |
| Fatigue | 2 (9) | — | |
| Laboratory | |||
| Liver enzymes (AST, ALT) | 6 (27) | — | |
| Alkaline phosphatase | 2 (9) | — | |
| Bilirubin | 2 (9) | — | |
| Toxicity . | No. (%) of patients . | ||
|---|---|---|---|
| Any grade . | Grade 3 or 4 . | ||
| Hematologic | |||
| Anemia | 6 (27) | 3 (14) | |
| Thrombocytopenia | 5 (23) | 5 (23) | |
| Nonhematologic | |||
| Diarrhea | 16 (73) | 2 (9) | |
| Nausea | 11 (50) | — | |
| Headache | 7 (32) | — | |
| Vomiting | 6 (27) | — | |
| Flatulence | 5 (23) | — | |
| Heartburn | 4 (18) | — | |
| Mucositis | 3 (14) | — | |
| Peripheral neuropathy | 3 (14) | — | |
| Anorexia | 2 (9) | — | |
| Fatigue | 2 (9) | — | |
| Laboratory | |||
| Liver enzymes (AST, ALT) | 6 (27) | — | |
| Alkaline phosphatase | 2 (9) | — | |
| Bilirubin | 2 (9) | — | |
AST indicates aspartate aminotransferase; ALT, alanine aminotransferase; and —, not applicable.