Recorded side effects of CEP-701 therapy
Toxicity . | No. (%) of patients . | ||
---|---|---|---|
Any grade . | Grade 3 or 4 . | ||
Hematologic | |||
Anemia | 6 (27) | 3 (14) | |
Thrombocytopenia | 5 (23) | 5 (23) | |
Nonhematologic | |||
Diarrhea | 16 (73) | 2 (9) | |
Nausea | 11 (50) | — | |
Headache | 7 (32) | — | |
Vomiting | 6 (27) | — | |
Flatulence | 5 (23) | — | |
Heartburn | 4 (18) | — | |
Mucositis | 3 (14) | — | |
Peripheral neuropathy | 3 (14) | — | |
Anorexia | 2 (9) | — | |
Fatigue | 2 (9) | — | |
Laboratory | |||
Liver enzymes (AST, ALT) | 6 (27) | — | |
Alkaline phosphatase | 2 (9) | — | |
Bilirubin | 2 (9) | — |
Toxicity . | No. (%) of patients . | ||
---|---|---|---|
Any grade . | Grade 3 or 4 . | ||
Hematologic | |||
Anemia | 6 (27) | 3 (14) | |
Thrombocytopenia | 5 (23) | 5 (23) | |
Nonhematologic | |||
Diarrhea | 16 (73) | 2 (9) | |
Nausea | 11 (50) | — | |
Headache | 7 (32) | — | |
Vomiting | 6 (27) | — | |
Flatulence | 5 (23) | — | |
Heartburn | 4 (18) | — | |
Mucositis | 3 (14) | — | |
Peripheral neuropathy | 3 (14) | — | |
Anorexia | 2 (9) | — | |
Fatigue | 2 (9) | — | |
Laboratory | |||
Liver enzymes (AST, ALT) | 6 (27) | — | |
Alkaline phosphatase | 2 (9) | — | |
Bilirubin | 2 (9) | — |
AST indicates aspartate aminotransferase; ALT, alanine aminotransferase; and —, not applicable.