Hematologic values by genotype
| Genotype . | RBC, × 106/μL . | Hgb, g/dL . | Hct, % . | MCV, fL . | MCH, pg . | MCHC, g/dL . | CHCM, g/dL . | RDW, % . | HDW, g/dL . |
|---|---|---|---|---|---|---|---|---|---|
| Male mice | |||||||||
| NOD-+/+ (5) | 9.1 ± 1.1 | 14.8 ± 2.2 | 44.6 ± 4.9 | 49.2 ± 1.8 | 16.5 ± 0.9 | 33.5 ± 1.3 | 32.8 ± 1.7 | 13.7 ± 0.6 | 2.1 ± 0.2 |
| sph3J/sph3J (5) | 3.3 ± 0.2* | 5.5 ± 0.2* | 16.6 ± 1.7* | 50.4 ± 5.5 | 16.8 ± 1.1 | 33.4 ± 2.2 | 29.2 ± 1.6† | 35.6 ± 1.5* | 4.6 ± 0.2* |
| B6-+/+ (8) | 9.8 ± 1.2 | 15.1 ± 1.7 | 45.6 ± 4.7 | 46.6 ± 1.2 | 15.5 ± 0.3 | 33.2 ± 0.9 | 31.0 ± 0.3 | 14.4 ± 2.0 | 1.9 ± 0.2 |
| sph4J/sph4J (20) | 3.2 ± 0.3* | 5.3 ± 0.4* | 18.7 ± 1.7* | 59.2 ± 5.3* | 16.6 ± 0.9† | 28.1 ± 1.4* | 26.5 ± 2.3* | 33.2 ± 2.7* | 4.6 ± 0.6* |
| Female mice | |||||||||
| NOD-+/+ (5) | 9.1 ± 0.2 | 15.3 ± 0.1 | 43.6 ± 0.7 | 46.1 ± 4.2 | 16.9 ± 0.2 | 35.1 ± 0.4 | 36.0 ± 0.5 | 14.5 ± 0.4 | 2.4 ± 0.1 |
| sph3J/sph3J (5) | 2.8 ± 0.7* | 4.5 ± 1.1* | 14.2 ± 2.6* | 52.4 ± 7.6 | 16.2 ± 0.8‡ | 31.1 ± 3.0† | 29.4 ± 1.8* | 32.9 ± 2.5* | 4.9 ± 0.3* |
| B6-+/+ (7) | 9.0 ± 1.3 | 13.8 ± 1.7 | 41.1 ± 3.4 | 46.0 ± 1.6 | 15.4 ± 0.4 | 33.6 ± 1.6 | 31.9 ± 1.3 | 15.5 ± 2.4 | 1.8 ± 0.1 |
| sph4J/sph4J (10) | 3.2 ± 0.2* | 5.4 ± 0.4* | 19.6 ± 1.9* | 60.3 ± 1.3* | 16.6 ± 0.7† | 27.6 ± 1.6* | 25.9 ± 2.9* | 33.5 ± 2.6* | 4.4 ± 0.7* |
| Genotype . | RBC, × 106/μL . | Hgb, g/dL . | Hct, % . | MCV, fL . | MCH, pg . | MCHC, g/dL . | CHCM, g/dL . | RDW, % . | HDW, g/dL . |
|---|---|---|---|---|---|---|---|---|---|
| Male mice | |||||||||
| NOD-+/+ (5) | 9.1 ± 1.1 | 14.8 ± 2.2 | 44.6 ± 4.9 | 49.2 ± 1.8 | 16.5 ± 0.9 | 33.5 ± 1.3 | 32.8 ± 1.7 | 13.7 ± 0.6 | 2.1 ± 0.2 |
| sph3J/sph3J (5) | 3.3 ± 0.2* | 5.5 ± 0.2* | 16.6 ± 1.7* | 50.4 ± 5.5 | 16.8 ± 1.1 | 33.4 ± 2.2 | 29.2 ± 1.6† | 35.6 ± 1.5* | 4.6 ± 0.2* |
| B6-+/+ (8) | 9.8 ± 1.2 | 15.1 ± 1.7 | 45.6 ± 4.7 | 46.6 ± 1.2 | 15.5 ± 0.3 | 33.2 ± 0.9 | 31.0 ± 0.3 | 14.4 ± 2.0 | 1.9 ± 0.2 |
| sph4J/sph4J (20) | 3.2 ± 0.3* | 5.3 ± 0.4* | 18.7 ± 1.7* | 59.2 ± 5.3* | 16.6 ± 0.9† | 28.1 ± 1.4* | 26.5 ± 2.3* | 33.2 ± 2.7* | 4.6 ± 0.6* |
| Female mice | |||||||||
| NOD-+/+ (5) | 9.1 ± 0.2 | 15.3 ± 0.1 | 43.6 ± 0.7 | 46.1 ± 4.2 | 16.9 ± 0.2 | 35.1 ± 0.4 | 36.0 ± 0.5 | 14.5 ± 0.4 | 2.4 ± 0.1 |
| sph3J/sph3J (5) | 2.8 ± 0.7* | 4.5 ± 1.1* | 14.2 ± 2.6* | 52.4 ± 7.6 | 16.2 ± 0.8‡ | 31.1 ± 3.0† | 29.4 ± 1.8* | 32.9 ± 2.5* | 4.9 ± 0.3* |
| B6-+/+ (7) | 9.0 ± 1.3 | 13.8 ± 1.7 | 41.1 ± 3.4 | 46.0 ± 1.6 | 15.4 ± 0.4 | 33.6 ± 1.6 | 31.9 ± 1.3 | 15.5 ± 2.4 | 1.8 ± 0.1 |
| sph4J/sph4J (10) | 3.2 ± 0.2* | 5.4 ± 0.4* | 19.6 ± 1.9* | 60.3 ± 1.3* | 16.6 ± 0.7† | 27.6 ± 1.6* | 25.9 ± 2.9* | 33.5 ± 2.6* | 4.4 ± 0.7* |
Number in parentheses indicates n (sample size). All values are stated as mean ± SD. All mice were ≥6 weeks of age.
CHCM indicates cell hemoglobin concentration mean; Hct, hematocrit; HDW, hemoglobin distribution width Hgb, hemoglobin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean cell volume; RBC, red blood cell count; and RDW, red cell distribution width.
P < .001 vs sex-matched control (+/+) mice.
P < .01 vs sex-matched control (+/+) mice.
P < .05 vs sex-matched control (+/+) mice.