MPL haplotypes in the United Kingdom population (n = 1500) and MPL mutated cases with a homozygous clone (n = 23)
| Haplotype no. . | rs1467809 . | rs1098182 . | rs12076751 . | rs1199038* . | rs11210838* . | rs4141740 . | rs4141741 . | rs839757* . | WTCCC frequency . | Expected (n = 23) . | Observed . | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MPL W515L/K allele (n = 23) . | Wild-type allele (n = 21) . | |||||||||||
| 1 | G | C | T | T | A | A | T | A | 0.132 | 3 | 3 | 4 |
| 3 | G | C | T | T | C | A | T | A | 0.204 | 5 | 9 | 4 |
| 29 | A | C | C | C | C | T | C | A | 0.269 | 6 | 4 | 7 |
| 30 | A | C | C | C | C | T | C | G | 0.271 | 6 | 6 | 4 |
| Haplotype no. . | rs1467809 . | rs1098182 . | rs12076751 . | rs1199038* . | rs11210838* . | rs4141740 . | rs4141741 . | rs839757* . | WTCCC frequency . | Expected (n = 23) . | Observed . | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MPL W515L/K allele (n = 23) . | Wild-type allele (n = 21) . | |||||||||||
| 1 | G | C | T | T | A | A | T | A | 0.132 | 3 | 3 | 4 |
| 3 | G | C | T | T | C | A | T | A | 0.204 | 5 | 9 | 4 |
| 29 | A | C | C | C | C | T | C | A | 0.269 | 6 | 4 | 7 |
| 30 | A | C | C | C | C | T | C | G | 0.271 | 6 | 6 | 4 |
WTCCC indicates Wellcome Trust Case Control Consortium.
SNPs that were genotyped in MPL mutated cases.