Multivariable Cox proportional hazard regression with time-dependent covariates in primary myelofibrosis for all ages and age younger than 65 years
| Time-dependent covariate . | HR . | 95% CI . | P . |
|---|---|---|---|
| All patients | |||
| Age older than 65 y | 1.98 | 1.52-2.60 | < .001 |
| WBC count greater than 25 × 109/L | 1.74 | 1.33-2.29 | < .001 |
| Hb level lower than 10 g/dL | 4.18 | 3.03-5.78 | < .001 |
| Peripheral blood blasts 1% or higher | 1.82 | 1.39-2.40 | < .001 |
| Constitutional symptoms | 2.06 | 1.61-2.65 | < .001 |
| Patients younger than 65 y | |||
| WBC count greater than 25 × 109/L | 1.7 | 1.01-2.95 | .048 |
| Hb level lower than 10 g/dL | 3.7 | 2.11-6.51 | < .001 |
| Peripheral blood blasts 1% or higher | 2.59 | 1.65-4.06 | < .001 |
| Constitutional symptoms | 3.04 | 1.93-4.80 | < .001 |
| Time-dependent covariate . | HR . | 95% CI . | P . |
|---|---|---|---|
| All patients | |||
| Age older than 65 y | 1.98 | 1.52-2.60 | < .001 |
| WBC count greater than 25 × 109/L | 1.74 | 1.33-2.29 | < .001 |
| Hb level lower than 10 g/dL | 4.18 | 3.03-5.78 | < .001 |
| Peripheral blood blasts 1% or higher | 1.82 | 1.39-2.40 | < .001 |
| Constitutional symptoms | 2.06 | 1.61-2.65 | < .001 |
| Patients younger than 65 y | |||
| WBC count greater than 25 × 109/L | 1.7 | 1.01-2.95 | .048 |
| Hb level lower than 10 g/dL | 3.7 | 2.11-6.51 | < .001 |
| Peripheral blood blasts 1% or higher | 2.59 | 1.65-4.06 | < .001 |
| Constitutional symptoms | 3.04 | 1.93-4.80 | < .001 |
HR indicates hazard ratio; WBC, white blood cell; and Hb, hemoglobin.