Effect of homozygosity at each of the three HLA class I loci -A, -B, and -C and level of homozygosity on the risk for NHL, DLBCL, and follicular lymphoma, compared to persons not homozygous for specified loci (adjusted for age, sex, and study center)
| . | . | Controls . | NHL . | DLBCL . | Follicular . | ||||
|---|---|---|---|---|---|---|---|---|---|
| n . | (%) . | n (%) . | OR (95% CI) . | n (%) . | OR (95% CI) . | n (%) . | OR (95% CI) . | ||
| HLA-A | No | 452 | (84) | 484 (84) | 1.00 (referent) | 137 (83) | 1.00 (referent) | 142 (88) | 1.00 (referent) |
| Yes | 83 | (16) | 93 (16) | 1.04 (0.75-1.43) | 28 (17) | 1.11 (0.69-1.78) | 20 (12) | 0.74 (0.44-1.26) | |
| HLA-B | No | 503 | (94) | 537 (93) | 1.00 (referent) | 149 (90) | 1.00 (referent) | 151 (93) | 1.00 (referent) |
| Yes | 34 | (6) | 43 (7) | 1.18 (0.74-1.89) | 16 (10) | 1.67 (0.89-3.13) | 12 (7) | 1.22 (0.61-2.45) | |
| HLA-C | No | 487 | (91) | 516 (89) | 1.00 (referent) | 146 (88) | 1.00 (referent) | 146 (90) | 1.00 (referent) |
| Yes | 48 | (9) | 65 (11) | 1.23 (0.83-1.83) | 20 (12) | 1.40 (0.80-2.45) | 17 (10) | 1.11 (0.61-2.02) | |
| No. of class I loci (HLA-A, -B, or -C) | 0 or 1 | 505 | (96) | 532 (93) | 1.00 (referent) | 149 (91) | 1.00 (referent) | 151 (93) | 1.00 (referent) |
| 2 | 17 | (3) | 31 (5) | 1.69 (0.92-3.10) | 9 (5) | 1.81 (0.78-4.17) | 8 (5) | 1.37 (0.57-3.28) | |
| 3 | 6 | (1) | 12 (2) | 1.94 (0.72-5.25) | 6 (4) | 3.66 (1.15-11.7) | 3 (2) | 1.81 (0.43-7.59) | |
| P trend | 0.04 | 0.01 | 0.3 | ||||||
| . | . | Controls . | NHL . | DLBCL . | Follicular . | ||||
|---|---|---|---|---|---|---|---|---|---|
| n . | (%) . | n (%) . | OR (95% CI) . | n (%) . | OR (95% CI) . | n (%) . | OR (95% CI) . | ||
| HLA-A | No | 452 | (84) | 484 (84) | 1.00 (referent) | 137 (83) | 1.00 (referent) | 142 (88) | 1.00 (referent) |
| Yes | 83 | (16) | 93 (16) | 1.04 (0.75-1.43) | 28 (17) | 1.11 (0.69-1.78) | 20 (12) | 0.74 (0.44-1.26) | |
| HLA-B | No | 503 | (94) | 537 (93) | 1.00 (referent) | 149 (90) | 1.00 (referent) | 151 (93) | 1.00 (referent) |
| Yes | 34 | (6) | 43 (7) | 1.18 (0.74-1.89) | 16 (10) | 1.67 (0.89-3.13) | 12 (7) | 1.22 (0.61-2.45) | |
| HLA-C | No | 487 | (91) | 516 (89) | 1.00 (referent) | 146 (88) | 1.00 (referent) | 146 (90) | 1.00 (referent) |
| Yes | 48 | (9) | 65 (11) | 1.23 (0.83-1.83) | 20 (12) | 1.40 (0.80-2.45) | 17 (10) | 1.11 (0.61-2.02) | |
| No. of class I loci (HLA-A, -B, or -C) | 0 or 1 | 505 | (96) | 532 (93) | 1.00 (referent) | 149 (91) | 1.00 (referent) | 151 (93) | 1.00 (referent) |
| 2 | 17 | (3) | 31 (5) | 1.69 (0.92-3.10) | 9 (5) | 1.81 (0.78-4.17) | 8 (5) | 1.37 (0.57-3.28) | |
| 3 | 6 | (1) | 12 (2) | 1.94 (0.72-5.25) | 6 (4) | 3.66 (1.15-11.7) | 3 (2) | 1.81 (0.43-7.59) | |
| P trend | 0.04 | 0.01 | 0.3 | ||||||
HLA indicates human leukocyte antigen; NHL, non-Hodgkin lymphoma; DLBCL, diffuse large B-cell lymphoma; OR, odds ratio; CI, confidence interval; and ref, referent.