HLA class I and II allele–disease associations with NHL overall and NHL subtypes (adjusted for age, sex, study site)
| Exposure . | Status . | Control, n (%) . | NHL, n (%) . | OR (95% CI) . | P . | DLBCL, n (%) . | OR (95% CI) . | P . | Follicular, n (%) . | OR (95% CI) . | P . | CLL/SLL, n (%) . | OR (95% CI) . | P . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HLA class I | ||||||||||||||
| HLA-A*2601 | Absent | 512 (96) | 531 (92) | 1.00 (ref) | 150 (91) | 1.00 (ref) | 151 (93) | 1.00 (ref) | 73 (89) | 1.00 (ref) | ||||
| Present | 23 (4) | 46 (8) | 1.88 (1.12-3.16) | .02 | 15 (9) | 2.27 (1.14-4.51) | .02 | 11 (7) | 1.61 (0.76-3.42) | .2 | 9 (11) | 2.69 (1.18-6.11) | .02 | |
| HLA-A*2902 | Absent | 493 (92) | 546 (95) | 1.00 (ref) | 159 (96) | 1.00 (ref) | 151 (93) | 1.00 (ref) | 78 (95) | 1.00 (ref) | ||||
| Present | 42 (8) | 31 (5) | 0.67 (0.41-1.09) | .1 | 6 (4) | 0.44 (0.18-1.06) | .07 | 11 (7) | 0.88 (0.44-1.77) | .7 | 4 (5) | * | * | |
| HLA-B*3503 | Absent | 512 (95) | 567 (98) | 1.00 (ref) | 161 (98) | 1.00 (ref) | 162 (99) | 1.00 (ref) | 78 (95) | 1.00 (ref) | ||||
| Present | 25 (5) | 13 (2) | 0.44 (0.22-0.87) | .02 | 4 (2) | * | * | 1 (1) | * | * | 4 (5) | * | * | |
| HLA-B*5101 | Absent | 496 (92) | 520 (90) | 1.00 (ref) | 143 (87) | 1.00 (ref) | 146 (90) | 1.00 (ref) | 76 (93) | 1.00 (ref) | ||||
| Present | 41 (8) | 60 (10) | 1.45 (0.95-2.21) | .08 | 22 (13) | 2.01 (1.15-3.53) | .01 | 17 (10) | 1.34 (0.73-2.47) | .3 | 6 (7) | 0.92 (0.37-2.25) | .8 | |
| HLA-Cw*0304 | Absent | 433 (81) | 490 (84) | 1.00 (ref) | 145 (87) | 1.00 (ref) | 141 (87) | 1.00 (ref) | 67 (83) | 1.00 (ref) | ||||
| Present | 102 (19) | 91 (16) | 0.8 (0.58-1.1) | .2 | 21 (13) | 0.61 (0.36-1.01) | .05 | 22 (14) | 0.69 (0.41-1.14) | .1 | 14 (17) | 0.86 (0.46-1.61) | .6 | |
| HLA-Cw*0701 | Absent | 386 (72) | 387 (67) | 1.00 (ref) | 107 (64) | 1.00 (ref) | 111 (68) | 1.00 (ref) | 57 (70) | 1.00 (ref) | ||||
| Present | 149 (28) | 194 (33) | 1.3 (1.01-1.69) | .04 | 59 (36) | 1.45 (1-2.1) | .05 | 52 (32) | 1.19 (0.81-1.75) | .4 | 24 (30) | 1.08 (0.64-1.81) | .8 | |
| HLA-Cw*1502 | Absent | 520 (97) | 554 (95) | 1.00 (ref) | 155 (93) | 1.00 (ref) | 157 (96) | 1.00 (ref) | 78 (96) | 1.00 (ref) | ||||
| Present | 15 (3) | 27 (5) | 1.76 (0.92-3.37) | .09 | 11 (7) | 2.8 (1.24-6.32) | .01 | 6 (4) | 1.23 (0.46-3.33) | .7 | 3 (4) | * | * | |
| HLA class II | ||||||||||||||
| HLA-DRB1*0101 | Absent | 432 (83) | 437 (79) | 1.00 (ref) | 122 (80) | 1.00 (ref) | 105 (70) | 1.00 (ref) | 68 (83) | 1.00 (ref) | ||||
| Present | 88 (17) | 113 (21) | 1.26 (0.92-1.72) | .1 | 31 (20) | 1.25 (0.79-1.98) | .3 | 46 (30) | 2.14 (1.4-3.26) | < .001 | 14 (17) | 0.95 (0.51-1.78) | .9 | |
| HLA-DRB1*0401 | Absent | 414 (80) | 460 (84) | 1.00 (ref) | 137 (90) | 1.00 (ref) | 118 (78) | 1.00 (ref) | 67 (82) | 1.00 (ref) | ||||
| Present | 106 (20) | 90 (16) | 0.78 (0.57-1.07) | .1 | 16 (10) | 0.45 (0.26-0.79) | .006 | 33 (22) | 1.12 (0.72-1.76) | .6 | 15 (18) | 0.93 (0.5-1.7) | .8 | |
| HLA-DRB1*0403 | Absent | 515 (99) | 535 (97) | 1.00 (ref) | 150 (98) | 1.00 (ref) | 146 (97) | 1.00 (ref) | 81 (99) | 1.00 (ref) | ||||
| Present | 5 (1) | 15 (3) | 2.71 (0.97-7.58) | .06 | 3 (2) | * | * | 5 (3) | 3.45 (0.95-12.47) | .06 | 1 (1) | * | * | |
| HLA-DRB1*13 (*1301, *1302, *1303) | Absent | 403 (77) | 456 (83) | 1.00 (ref) | 127 (83) | 1.00 (ref) | 133 (88) | 1.00 (ref) | 70 (85) | 1.00 (ref) | ||||
| Present | 117 (23) | 94 (17) | 0.71 (0.52-0.97) | .03 | 26 (17) | 0.75 (0.46-1.20) | .2 | 18 (12) | 0.48 (0.28-0.82) | .008 | 12 (15) | 0.59 (0.31-1.13) | .1 | |
| HLA-DRB1*1301 | Absent | 463 (89) | 504 (92) | 1.00 (ref) | 142 (93) | 1.00 (ref) | 145 (96) | 1.00 (ref) | 77 (94) | 1.00 (ref) | ||||
| Present | 57 (11) | 46 (8) | 0.74 (0.49-1.11) | .1 | 11 (7) | 0.66 (0.34-1.3) | .2 | 6 (4) | 0.35 (0.15-0.83) | .02 | 5 (6) | 0.54 (0.21-1.39) | .2 | |
| HLA-DRB1*1302 | Absent | 469 (90) | 507 (92) | 1.00 (ref) | 139 (91) | 1.00 (ref) | 142 (94) | 1.00 (ref) | 76 (93) | 1.00 (ref) | ||||
| Present | 51 (10) | 43 (8) | 0.81 (0.52-1.24) | .3 | 14 (9) | 1 (0.54-1.88) | .9 | 9 (6) | 0.61 (0.29-1.28) | .2 | 6 (7) | 0.72 (0.3-1.76) | .5 | |
| HLA-DRB1*1303 | Absent | 507 (98) | 542 (99) | 1.00 (ref) | 152 (99) | 1.00 (ref) | 148 (98) | 1.00 (ref) | 80 (98) | 1.00 (ref) | ||||
| Present | 13 (3) | 8 (1) | 0.54 (0.22-1.32) | .2 | 1 (1) | * | * | 3 (2) | * | * | 2 (2) | * | * |
| Exposure . | Status . | Control, n (%) . | NHL, n (%) . | OR (95% CI) . | P . | DLBCL, n (%) . | OR (95% CI) . | P . | Follicular, n (%) . | OR (95% CI) . | P . | CLL/SLL, n (%) . | OR (95% CI) . | P . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HLA class I | ||||||||||||||
| HLA-A*2601 | Absent | 512 (96) | 531 (92) | 1.00 (ref) | 150 (91) | 1.00 (ref) | 151 (93) | 1.00 (ref) | 73 (89) | 1.00 (ref) | ||||
| Present | 23 (4) | 46 (8) | 1.88 (1.12-3.16) | .02 | 15 (9) | 2.27 (1.14-4.51) | .02 | 11 (7) | 1.61 (0.76-3.42) | .2 | 9 (11) | 2.69 (1.18-6.11) | .02 | |
| HLA-A*2902 | Absent | 493 (92) | 546 (95) | 1.00 (ref) | 159 (96) | 1.00 (ref) | 151 (93) | 1.00 (ref) | 78 (95) | 1.00 (ref) | ||||
| Present | 42 (8) | 31 (5) | 0.67 (0.41-1.09) | .1 | 6 (4) | 0.44 (0.18-1.06) | .07 | 11 (7) | 0.88 (0.44-1.77) | .7 | 4 (5) | * | * | |
| HLA-B*3503 | Absent | 512 (95) | 567 (98) | 1.00 (ref) | 161 (98) | 1.00 (ref) | 162 (99) | 1.00 (ref) | 78 (95) | 1.00 (ref) | ||||
| Present | 25 (5) | 13 (2) | 0.44 (0.22-0.87) | .02 | 4 (2) | * | * | 1 (1) | * | * | 4 (5) | * | * | |
| HLA-B*5101 | Absent | 496 (92) | 520 (90) | 1.00 (ref) | 143 (87) | 1.00 (ref) | 146 (90) | 1.00 (ref) | 76 (93) | 1.00 (ref) | ||||
| Present | 41 (8) | 60 (10) | 1.45 (0.95-2.21) | .08 | 22 (13) | 2.01 (1.15-3.53) | .01 | 17 (10) | 1.34 (0.73-2.47) | .3 | 6 (7) | 0.92 (0.37-2.25) | .8 | |
| HLA-Cw*0304 | Absent | 433 (81) | 490 (84) | 1.00 (ref) | 145 (87) | 1.00 (ref) | 141 (87) | 1.00 (ref) | 67 (83) | 1.00 (ref) | ||||
| Present | 102 (19) | 91 (16) | 0.8 (0.58-1.1) | .2 | 21 (13) | 0.61 (0.36-1.01) | .05 | 22 (14) | 0.69 (0.41-1.14) | .1 | 14 (17) | 0.86 (0.46-1.61) | .6 | |
| HLA-Cw*0701 | Absent | 386 (72) | 387 (67) | 1.00 (ref) | 107 (64) | 1.00 (ref) | 111 (68) | 1.00 (ref) | 57 (70) | 1.00 (ref) | ||||
| Present | 149 (28) | 194 (33) | 1.3 (1.01-1.69) | .04 | 59 (36) | 1.45 (1-2.1) | .05 | 52 (32) | 1.19 (0.81-1.75) | .4 | 24 (30) | 1.08 (0.64-1.81) | .8 | |
| HLA-Cw*1502 | Absent | 520 (97) | 554 (95) | 1.00 (ref) | 155 (93) | 1.00 (ref) | 157 (96) | 1.00 (ref) | 78 (96) | 1.00 (ref) | ||||
| Present | 15 (3) | 27 (5) | 1.76 (0.92-3.37) | .09 | 11 (7) | 2.8 (1.24-6.32) | .01 | 6 (4) | 1.23 (0.46-3.33) | .7 | 3 (4) | * | * | |
| HLA class II | ||||||||||||||
| HLA-DRB1*0101 | Absent | 432 (83) | 437 (79) | 1.00 (ref) | 122 (80) | 1.00 (ref) | 105 (70) | 1.00 (ref) | 68 (83) | 1.00 (ref) | ||||
| Present | 88 (17) | 113 (21) | 1.26 (0.92-1.72) | .1 | 31 (20) | 1.25 (0.79-1.98) | .3 | 46 (30) | 2.14 (1.4-3.26) | < .001 | 14 (17) | 0.95 (0.51-1.78) | .9 | |
| HLA-DRB1*0401 | Absent | 414 (80) | 460 (84) | 1.00 (ref) | 137 (90) | 1.00 (ref) | 118 (78) | 1.00 (ref) | 67 (82) | 1.00 (ref) | ||||
| Present | 106 (20) | 90 (16) | 0.78 (0.57-1.07) | .1 | 16 (10) | 0.45 (0.26-0.79) | .006 | 33 (22) | 1.12 (0.72-1.76) | .6 | 15 (18) | 0.93 (0.5-1.7) | .8 | |
| HLA-DRB1*0403 | Absent | 515 (99) | 535 (97) | 1.00 (ref) | 150 (98) | 1.00 (ref) | 146 (97) | 1.00 (ref) | 81 (99) | 1.00 (ref) | ||||
| Present | 5 (1) | 15 (3) | 2.71 (0.97-7.58) | .06 | 3 (2) | * | * | 5 (3) | 3.45 (0.95-12.47) | .06 | 1 (1) | * | * | |
| HLA-DRB1*13 (*1301, *1302, *1303) | Absent | 403 (77) | 456 (83) | 1.00 (ref) | 127 (83) | 1.00 (ref) | 133 (88) | 1.00 (ref) | 70 (85) | 1.00 (ref) | ||||
| Present | 117 (23) | 94 (17) | 0.71 (0.52-0.97) | .03 | 26 (17) | 0.75 (0.46-1.20) | .2 | 18 (12) | 0.48 (0.28-0.82) | .008 | 12 (15) | 0.59 (0.31-1.13) | .1 | |
| HLA-DRB1*1301 | Absent | 463 (89) | 504 (92) | 1.00 (ref) | 142 (93) | 1.00 (ref) | 145 (96) | 1.00 (ref) | 77 (94) | 1.00 (ref) | ||||
| Present | 57 (11) | 46 (8) | 0.74 (0.49-1.11) | .1 | 11 (7) | 0.66 (0.34-1.3) | .2 | 6 (4) | 0.35 (0.15-0.83) | .02 | 5 (6) | 0.54 (0.21-1.39) | .2 | |
| HLA-DRB1*1302 | Absent | 469 (90) | 507 (92) | 1.00 (ref) | 139 (91) | 1.00 (ref) | 142 (94) | 1.00 (ref) | 76 (93) | 1.00 (ref) | ||||
| Present | 51 (10) | 43 (8) | 0.81 (0.52-1.24) | .3 | 14 (9) | 1 (0.54-1.88) | .9 | 9 (6) | 0.61 (0.29-1.28) | .2 | 6 (7) | 0.72 (0.3-1.76) | .5 | |
| HLA-DRB1*1303 | Absent | 507 (98) | 542 (99) | 1.00 (ref) | 152 (99) | 1.00 (ref) | 148 (98) | 1.00 (ref) | 80 (98) | 1.00 (ref) | ||||
| Present | 13 (3) | 8 (1) | 0.54 (0.22-1.32) | .2 | 1 (1) | * | * | 3 (2) | * | * | 2 (2) | * | * |
HLA indicates human leukocyte antigen; NHL, non-Hodgkin lymphoma; DLBCL, diffuse large B-cell lymphoma; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; OR, odds ratio; CI, confidence intervals; and ref, referent.
ORs not calculated for cells with less than 5 people.