Outcome according to initial stratification and randomization
| N (%) Median (Q1-Q3) . | Randomized patients . | Nonrandomized patients . | ||
|---|---|---|---|---|
| ATRA→CT . | ATRA+CT . | High WBC . | Elderly group . | |
| No. of patients | 122 | 184 | 215 | 55 |
| Male sex | 59 (48.4) | 87 (47.3) | 113 (52.6) | 31 (56.4) |
| Age, y (range) | 46 (35-54) | 44 (33-55) | 43 (28-54) | 69 (67-72) |
| WBC count, 109/L (range) | 1.3 (0.8-2.25) | 1.4 (0.9-2.5) | 14.8 (7.9-35.3) | 1.3 (0.9-1.9) |
| Platelet count, 109/L (range) | 40 (14-69) | 33 (18-60) | 24 (16-40) | 36 (20-71) |
| Circulating blasts, % (range) | 20 (2-48) | 17 (2-47) | 83 (65-90) | 19 (5-42.5) |
| Microgranular variant (range) | 6 (5.2) | 10 (5.7) | 62 (30.1) | 3 (5.6) |
| Fibrinogen level, g/L (range) | 19 (12-28) | 17 (12-25) | 14 (9-21) | 19 (13-33) |
| CR: N (%) | 113 (92.6) | 177 (96.2) | 195 (90.7) | 48 (87.3) |
| 10-year CI of relapse | 21.6% | 13.2% | 37.9% | 9.3% |
| 10-year CI of deaths in CR | 6.6% | 6.7% | 4.7% | 21.7% |
| 10-year EFS | 64.4% | 76.3% | 48.1% | 59.5% |
| 10-year survival | 81.8% | 85.0% | 63.1% | 58.1% |
| N (%) Median (Q1-Q3) . | Randomized patients . | Nonrandomized patients . | ||
|---|---|---|---|---|
| ATRA→CT . | ATRA+CT . | High WBC . | Elderly group . | |
| No. of patients | 122 | 184 | 215 | 55 |
| Male sex | 59 (48.4) | 87 (47.3) | 113 (52.6) | 31 (56.4) |
| Age, y (range) | 46 (35-54) | 44 (33-55) | 43 (28-54) | 69 (67-72) |
| WBC count, 109/L (range) | 1.3 (0.8-2.25) | 1.4 (0.9-2.5) | 14.8 (7.9-35.3) | 1.3 (0.9-1.9) |
| Platelet count, 109/L (range) | 40 (14-69) | 33 (18-60) | 24 (16-40) | 36 (20-71) |
| Circulating blasts, % (range) | 20 (2-48) | 17 (2-47) | 83 (65-90) | 19 (5-42.5) |
| Microgranular variant (range) | 6 (5.2) | 10 (5.7) | 62 (30.1) | 3 (5.6) |
| Fibrinogen level, g/L (range) | 19 (12-28) | 17 (12-25) | 14 (9-21) | 19 (13-33) |
| CR: N (%) | 113 (92.6) | 177 (96.2) | 195 (90.7) | 48 (87.3) |
| 10-year CI of relapse | 21.6% | 13.2% | 37.9% | 9.3% |
| 10-year CI of deaths in CR | 6.6% | 6.7% | 4.7% | 21.7% |
| 10-year EFS | 64.4% | 76.3% | 48.1% | 59.5% |
| 10-year survival | 81.8% | 85.0% | 63.1% | 58.1% |
WBC indicates white blood cells; CR, complete remission; EFS, event-free survival; and CI, cumulative incidence.