Association between SNPs and ALL risk
| SNP (gene) . | Population . | Genotype . | Cases (%) . | Controls (%) . | OR (95% CI) . | P . |
|---|---|---|---|---|---|---|
| rs4132601 (IKZF1) | German | AA | 471 (39.6) | 811 (54.0) | 1.0 (referent) | |
| AC | 552 (46.4) | 574 (38.2) | 1.7 (1.4-2.0) | 1.2 × 10−9 | ||
| CC | 166 (14.0) | 116 (7.8) | 2.5 (1.9-3.2) | 7.6 × 10−12 | ||
| United Kingdom | AA | 60 (31.9) | 206 (57.2) | 1.0 (referent) | ||
| AC | 96 (51.1) | 133 (36.9) | 2.5 (1.7-3.7) | 3.8 × 10−6 | ||
| CC | 32 (17.0) | 21 (5.8) | 5.2 (2.7-10.2) | 2.9 × 10−8 | ||
| Overall | AA | 531 (38.6) | 1017 (54.6) | 1.0 (referent) | ||
| AC | 648 (47.0) | 707 (38.0) | 1.8 (1.5-2.0) | 1.4 × 10−13 | ||
| CC | 198 (14.4) | 137 (7.4) | 2.8 (2.2-3.6) | 2.9 × 10−17 | ||
| rs7089424 (ARIDB5) | German | AA | 346 (29.0) | 683 (45.3) | 1.0 (referent) | |
| AC | 595 (50.0) | 673 (44.6) | 1.8 (1.5-2.1) | 1.1 × 10−10 | ||
| CC | 249 (21.0) | 152 (10.1) | 3.2 (2.5-4.1) | 1.0 × 10−22 | ||
| United Kingdom | AA | 46 (25.0) | 153 (43.0) | 1.0 (referent) | ||
| AC | 99 (53.8) | 165 (46.3) | 2.0 (1.3-3.0) | 9.5 × 10−4 | ||
| CC | 39 (21.2) | 38 (10.7) | 3.4 (1.9-6.1) | 8.8 × 10−6 | ||
| Overall | AA | 392 (28.5) | 836 (44.9) | 1.0 (referent) | ||
| AC | 694 (50.5) | 838 (44.9) | 1.8 (1.5-2.1) | 8.7 × 10−13 | ||
| CC | 288 (21.0) | 190 (10.2) | 3.2 (2.6-4.0) | 7.1 × 10−27 | ||
| rs2239633 (CEBPE) | German | AA | 197 (16.5) | 307 (20.3) | 1.0 (referent) | |
| AG | 559 (46.9) | 773 (51.2) | 1.1 (0.9-1.4) | 2.6 × 10−1 | ||
| GG | 437 (36.6) | 430 (28.5) | 1.6 (1.3-2.0) | 5.1 × 10−5 | ||
| United Kingdom | AA | 26 (14.2) | 64 (18.2) | 1.0 (referent) | ||
| AG | 95 (51.9) | 183 (52.0) | 1.3 (0.7-2.2) | 3.5 × 10−1 | ||
| GG | 62 (33.9) | 105 (29.8) | 1.5 (0.8-2.6) | 1.8 × 10−1 | ||
| Overall | AA | 223 (16.2) | 371 (20.0) | 1.0 (referent) | ||
| AG | 654 (47.5) | 956 (51.3) | 1.1 (0.9-1.4) | 1.9 × 10−1 | ||
| GG | 499 (36.3) | 535 (28.7) | 1.6 (1.3-1.9) | 2.8 × 10−5 |
| SNP (gene) . | Population . | Genotype . | Cases (%) . | Controls (%) . | OR (95% CI) . | P . |
|---|---|---|---|---|---|---|
| rs4132601 (IKZF1) | German | AA | 471 (39.6) | 811 (54.0) | 1.0 (referent) | |
| AC | 552 (46.4) | 574 (38.2) | 1.7 (1.4-2.0) | 1.2 × 10−9 | ||
| CC | 166 (14.0) | 116 (7.8) | 2.5 (1.9-3.2) | 7.6 × 10−12 | ||
| United Kingdom | AA | 60 (31.9) | 206 (57.2) | 1.0 (referent) | ||
| AC | 96 (51.1) | 133 (36.9) | 2.5 (1.7-3.7) | 3.8 × 10−6 | ||
| CC | 32 (17.0) | 21 (5.8) | 5.2 (2.7-10.2) | 2.9 × 10−8 | ||
| Overall | AA | 531 (38.6) | 1017 (54.6) | 1.0 (referent) | ||
| AC | 648 (47.0) | 707 (38.0) | 1.8 (1.5-2.0) | 1.4 × 10−13 | ||
| CC | 198 (14.4) | 137 (7.4) | 2.8 (2.2-3.6) | 2.9 × 10−17 | ||
| rs7089424 (ARIDB5) | German | AA | 346 (29.0) | 683 (45.3) | 1.0 (referent) | |
| AC | 595 (50.0) | 673 (44.6) | 1.8 (1.5-2.1) | 1.1 × 10−10 | ||
| CC | 249 (21.0) | 152 (10.1) | 3.2 (2.5-4.1) | 1.0 × 10−22 | ||
| United Kingdom | AA | 46 (25.0) | 153 (43.0) | 1.0 (referent) | ||
| AC | 99 (53.8) | 165 (46.3) | 2.0 (1.3-3.0) | 9.5 × 10−4 | ||
| CC | 39 (21.2) | 38 (10.7) | 3.4 (1.9-6.1) | 8.8 × 10−6 | ||
| Overall | AA | 392 (28.5) | 836 (44.9) | 1.0 (referent) | ||
| AC | 694 (50.5) | 838 (44.9) | 1.8 (1.5-2.1) | 8.7 × 10−13 | ||
| CC | 288 (21.0) | 190 (10.2) | 3.2 (2.6-4.0) | 7.1 × 10−27 | ||
| rs2239633 (CEBPE) | German | AA | 197 (16.5) | 307 (20.3) | 1.0 (referent) | |
| AG | 559 (46.9) | 773 (51.2) | 1.1 (0.9-1.4) | 2.6 × 10−1 | ||
| GG | 437 (36.6) | 430 (28.5) | 1.6 (1.3-2.0) | 5.1 × 10−5 | ||
| United Kingdom | AA | 26 (14.2) | 64 (18.2) | 1.0 (referent) | ||
| AG | 95 (51.9) | 183 (52.0) | 1.3 (0.7-2.2) | 3.5 × 10−1 | ||
| GG | 62 (33.9) | 105 (29.8) | 1.5 (0.8-2.6) | 1.8 × 10−1 | ||
| Overall | AA | 223 (16.2) | 371 (20.0) | 1.0 (referent) | ||
| AG | 654 (47.5) | 956 (51.3) | 1.1 (0.9-1.4) | 1.9 × 10−1 | ||
| GG | 499 (36.3) | 535 (28.7) | 1.6 (1.3-1.9) | 2.8 × 10−5 |