Four ROH significantly associated with BCP-ALL risk (P < .01)
| ROH . | Chromosome . | Start, bp . | End, bp . | Length, bp . | No. of SNPs . | No. (%) of cases . | No. (%) of controls . | χ2 . | P . |
|---|---|---|---|---|---|---|---|---|---|
| ROH261 | 10p11.21-10q11.21 | 36 774 789 | 44 190 246 | 7 415 457 | 317 | 26 (3.4) | 140 (5.9) | 9.58 | < .002 |
| ROH15 | 1p31.1-1p31.1 | 70 726 887 | 76 563 751 | 5 836 864 | 463 | 27 (3.2) | 137 (5.8) | 8.04 | < .005 |
| ROH380 | 19p13.2-19p13.13 | 11 145 302 | 12 633 165 | 1 487 863 | 115 | 18 (2.2) | 22 (0.9) | 7.69 | < .006 |
| ROH388 | 20q11.1-20q11.23 | 28 121 437 | 35 496 979 | 7 375 542 | 401 | 67 (8.1) | 270 (11.4) | 7.14 | > .007 |
| ROH . | Chromosome . | Start, bp . | End, bp . | Length, bp . | No. of SNPs . | No. (%) of cases . | No. (%) of controls . | χ2 . | P . |
|---|---|---|---|---|---|---|---|---|---|
| ROH261 | 10p11.21-10q11.21 | 36 774 789 | 44 190 246 | 7 415 457 | 317 | 26 (3.4) | 140 (5.9) | 9.58 | < .002 |
| ROH15 | 1p31.1-1p31.1 | 70 726 887 | 76 563 751 | 5 836 864 | 463 | 27 (3.2) | 137 (5.8) | 8.04 | < .005 |
| ROH380 | 19p13.2-19p13.13 | 11 145 302 | 12 633 165 | 1 487 863 | 115 | 18 (2.2) | 22 (0.9) | 7.69 | < .006 |
| ROH388 | 20q11.1-20q11.23 | 28 121 437 | 35 496 979 | 7 375 542 | 401 | 67 (8.1) | 270 (11.4) | 7.14 | > .007 |
ROH indicates regions of homozygosity; BCP-ALL, B-cell precursor acute lymphoblastic leukemia; and SNP, single nucleotide polymorphism.