Effects of clinical factors on OS in Cox analyses
| Clinical factor . | All patients (n = 90) . | Patients had not received chemotherapy (n = 78) . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate model A . | Multivariate model B . | Univariate analysis . | Multivariate model C . | Multivariate model D . | |||||||
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| PS | ||||||||||||
| 0 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| 1 | 1.5 (0.8-2.7) | .22 | 1.4 (0.8-2.8) | .27 | 1.3 (0.7-2.6) | .37 | 1.4 (0.7-2.7) | .28 | 1.6 (0.8-3.1) | .21 | 1.4 (0.7-2.9) | .30 |
| 2 or more | 2.5 (1.2-5.2) | .01 | 2.1 (1.0-4.6) | .06 | 2.1 (1.0-4.6) | .06 | 1.7 (0.7-4.0) | .26 | 1.5 (0.6-3.8) | .39 | 1.6 (0.6-4.2) | .30 |
| Neutrophil counts | ||||||||||||
| Less than 7.5 × 109/L | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| 7.5 × 109/L or greater | 1.6 (0.9-2.9) | .15 | 1.3 (0.6-2.7) | .45 | 1.2 (0.6-2.3) | .58 | 1.3 (0.6-2.7) | .47 | 1.5 (0.6-3.8) | .43 | 1.0 (0.5-2.3) | .94 |
| LDH | ||||||||||||
| Less than or equal to NI | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Greater than NI | 1.7 (1.0-2.9) | .04 | 1.5 (0.8-2.7) | .16 | 1.5 (0.8-2.6) | .21 | 1.5 (0.8-2.8) | .19 | 1.7 (0.9-3.3) | .12 | 1.6 (0.8-3.1) | .20 |
| No. of extranodal lesions | ||||||||||||
| 0-2 | 1 | 1 | 1 | 1 | ||||||||
| 3 or more | 1.5 (0.8-2.8) | .16 | 0.7 (0.3-1.6) | .41 | 0.9 (0.4-2.2) | .82 | 0.5 (0.1-1.6) | .22 | ||||
| No. of total involved lesions | ||||||||||||
| 1 | 1 | 1 | 1 | 1 | ||||||||
| 2 or 3 | 1.2 (0.7-2.2) | .52 | 0.8 (0.4-1.6) | .52 | 1.1 (0.6-2.1) | .67 | 0.9 (0.4-1.7) | .65 | ||||
| 4 or more | 1.5 (0.7-3.0) | .26 | 0.9 (0.4-2.1) | .83 | 1.0 (0.5-2.3) | .96 | 0.8 (0.3-2.0) | .67 | ||||
| Chemotherapy | ||||||||||||
| Not received | 1 | 1 | 1 | |||||||||
| Received | 2.6 (1.4-5.1) | .003 | 2.3 (1.1-4.7) | .03 | 2.0 (1.0-4.2) | .06 | ||||||
| Clinical factor . | All patients (n = 90) . | Patients had not received chemotherapy (n = 78) . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis . | Multivariate model A . | Multivariate model B . | Univariate analysis . | Multivariate model C . | Multivariate model D . | |||||||
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| PS | ||||||||||||
| 0 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| 1 | 1.5 (0.8-2.7) | .22 | 1.4 (0.8-2.8) | .27 | 1.3 (0.7-2.6) | .37 | 1.4 (0.7-2.7) | .28 | 1.6 (0.8-3.1) | .21 | 1.4 (0.7-2.9) | .30 |
| 2 or more | 2.5 (1.2-5.2) | .01 | 2.1 (1.0-4.6) | .06 | 2.1 (1.0-4.6) | .06 | 1.7 (0.7-4.0) | .26 | 1.5 (0.6-3.8) | .39 | 1.6 (0.6-4.2) | .30 |
| Neutrophil counts | ||||||||||||
| Less than 7.5 × 109/L | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| 7.5 × 109/L or greater | 1.6 (0.9-2.9) | .15 | 1.3 (0.6-2.7) | .45 | 1.2 (0.6-2.3) | .58 | 1.3 (0.6-2.7) | .47 | 1.5 (0.6-3.8) | .43 | 1.0 (0.5-2.3) | .94 |
| LDH | ||||||||||||
| Less than or equal to NI | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Greater than NI | 1.7 (1.0-2.9) | .04 | 1.5 (0.8-2.7) | .16 | 1.5 (0.8-2.6) | .21 | 1.5 (0.8-2.8) | .19 | 1.7 (0.9-3.3) | .12 | 1.6 (0.8-3.1) | .20 |
| No. of extranodal lesions | ||||||||||||
| 0-2 | 1 | 1 | 1 | 1 | ||||||||
| 3 or more | 1.5 (0.8-2.8) | .16 | 0.7 (0.3-1.6) | .41 | 0.9 (0.4-2.2) | .82 | 0.5 (0.1-1.6) | .22 | ||||
| No. of total involved lesions | ||||||||||||
| 1 | 1 | 1 | 1 | 1 | ||||||||
| 2 or 3 | 1.2 (0.7-2.2) | .52 | 0.8 (0.4-1.6) | .52 | 1.1 (0.6-2.1) | .67 | 0.9 (0.4-1.7) | .65 | ||||
| 4 or more | 1.5 (0.7-3.0) | .26 | 0.9 (0.4-2.1) | .83 | 1.0 (0.5-2.3) | .96 | 0.8 (0.3-2.0) | .67 | ||||
| Chemotherapy | ||||||||||||
| Not received | 1 | 1 | 1 | |||||||||
| Received | 2.6 (1.4-5.1) | .003 | 2.3 (1.1-4.7) | .03 | 2.0 (1.0-4.2) | .06 | ||||||
HR indicates hazard ratio; 95% CI, 95% confidence interval; and NI, normal index.