Ninety-nine genes significantly correlated (at an FDR of 0%) with eigenvalues from the PCA of immunologic parameters in the 20 HIV-infected persons
| Symbol . | Score . | Gene name . |
|---|---|---|
| IRF9 | 7.63969424 | Interferon-stimulated transcription factor 3, gamma 48 kDa |
| IFI44 | 6.463064537 | Interferon-induced protein 44 |
| PARP9 | 6.331458105 | Poly (ADP-ribose) polymerase family, member 9 |
| OAS2 | 6.080896015 | 2′-5′-Oligoadenylate synthetase 2, 69/71kDa |
| ISG15 | 5.653887207 | Interferon, alpha-inducible protein (clone IFI-15K) |
| LAP3 | 5.562707184 | Leucine aminopeptidase 3 |
| IFITM1 | 5.309911759 | Interferon-induced transmembrane protein 1 (9-27) |
| SERPING1 | 5.295948182 | Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) |
| RNF213 | 5.268344777 | Chromosome 17 open reading frame 27 |
| SP110 | 5.256872524 | SP110 nuclear body protein |
| TRIM22 | 5.161555429 | Tripartite motif–containing 22 |
| STAT1 | 5.160281208 | Signal transducer and activator of transcription 1, 91 kDa |
| FGL2 | 5.059764921 | Fibrinogen-like 2 |
| MX1 | 5.052279793 | Myxovirus (influenza virus) resistance 1, interferon-inducible protein P78 (mouse) |
| HERC6 | 4.969209215 | HECT domain and RLD 6 |
| TAP1 | 4.925673126 | Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP) |
| IFIT2 | 4.851202317 | Interferon-induced protein with tetratricopeptide repeats 2 |
| TYROBP | 4.643418344 | Tyro protein tyrosine kinase binding protein |
| PSMB9 | 4.61684985 | Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) |
| ACOT7 | 4.474890582 | ACYL-COA thioesterase 7 |
| CCL4L2 | 4.435460418 | Chemokine (C-C motif) ligand 4 |
| GIMAP7 | 4.387779639 | GTPASE, IMAP family member 7 |
| IFIT3 | 4.377142549 | Interferon-induced protein with tetratricopeptide repeats 3 |
| STAT2 | 4.360968495 | Signal transducer and activator of transcription 2, 113 kDa |
| C1S | 4.356075207 | Complement component 1, S subcomponent |
| IFI35 | 4.297139761 | Interferon-induced protein 35 |
| IFITM4P | 4.23435714 | Interferon induced transmembrane protein 4 pseudogene |
| PNCK | 4.23295043 | Pregnancy up-regulated nonubiquitously expressed CAM kinase |
| ARHGAP25 | 4.190769686 | RHO GTPase activating protein 25 |
| GIMAP5 | 4.184925108 | GTPase, IMAP family member 5 |
| CXCL10 | 4.165976731 | Chemokine (C-X-C motif) ligand 10 |
| IL8RB | 4.152775449 | Interleukin 8 receptor, BETA |
| APOL3 | 4.134889167 | TNF-inducible protein CG12-1 |
| IFITM2 | 4.071757562 | Interferon induced transmembrane protein 2 (1-8D) |
| IL15 | 4.056626891 | Interleukin 15 |
| ZNFX1 | 3.992991172 | ZINC finger, NFX1-type containing 1 |
| CTSK | 3.987687377 | Cathepsin K (pycnodysostosis) |
| OASL | 3.972065117 | 2′-5′-Oligoadenylate synthetase-like |
| TRAalpha | 3.95014906 | T-cell receptor alpha locus |
| SRGN | 3.909639447 | Proteoglycan 1, secretory granule |
| CCL4L2 | 3.880280761 | Chemokine (C-C motif) ligand 4 |
| BTN3A3 | 3.862827621 | Butyrophilin, subfamily 3, member A3 |
| DTX3L | 3.834935982 | Deltex 3-like (drosophila) |
| NA | 3.812138625 | NA |
| CCL19 | 3.782911188 | Chemokine (C-C MOTIF) ligand 19 |
| ADAR | 3.779240486 | Adenosine deaminase, RNA specific |
| REC8 | 3.777102872 | REC8-like 1 (yeast) |
| KIAA1949 | 3.745843871 | KIAA1949 |
| ARL4C | 3.727007283 | ADP-ribosylation factor-like 4C |
| ARHGAP9 | 3.725234545 | RHO GTPase activating protein 9 |
| CORO1A | 3.715238075 | Coronin, actin binding protein, 1A |
| INDO | 3.67830532 | Indoleamine-pyrrole 2,3 dioxygenase |
| RAB31 | 3.67336941 | RAB31, member RAS oncogene family |
| COTL1 | 3.659705292 | Coactosin-like 1 (dictyostelium) |
| GMFG | 3.658192955 | GLIA maturation factor, GAMMA |
| SLA | 3.656310796 | SRC-like adaptor |
| BUB1 | 3.648122755 | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) |
| C1QA | 3.639355563 | Complement component 1, Q subcomponent, A chain |
| RAC2 | 3.632653776 | RAS-related C3 botulinum toxin substrate 2 (RHO family, small GTP binding protein RAC2) |
| CDC2 | 3.631566177 | Cell division cycle 2, G1 TO S and G2 to M |
| CLU | 3.626085643 | Clusterin |
| CCL3 | 3.621733073 | Chemokine (C-C MOTIF) ligand 3 |
| ECGF1 | 3.603371522 | Endothelial cell growth factor 1 (platelet-derived) |
| C1ORF54 | 3.599083135 | Chromosome 1 open reading frame 54 |
| HCLS1 | 3.598945235 | Hematopoietic cell-specific lyn substrate 1 |
| NA | 3.587802729 | NA |
| CCL4L2 | 3.584485049 | Chemokine (C-C MOTIF) ligand 4 |
| GBP2 | 3.584220194 | Guanylate binding protein 2, interferon-inducible |
| CXORF9 | 3.569357482 | Chromosome X open reading frame 9 |
| FAM14B | 3.552293235 | Family with sequence similarity 14, member B |
| EMILIN1 | 3.549670469 | Elastin microfibril interfacer 1 |
| PRPS2 | 3.539994216 | Phosphoribosyl pyrophosphate synthetase 1 |
| KIAA0082 | 3.530559508 | KIAA0082 |
| TSPAN14 | 3.527596769 | Tetraspanin 14 |
| FCER1G | 3.52450567 | Fc fragment of ige, high affinity I, receptor for gamma polypeptide |
| TREX1 | 3.514961993 | Three prime repair exonuclease 1 |
| VAMP1 | 3.510867551 | Vesicle-associated membrane protein 1 (synaptobrevin 1) |
| ALAS2 | 3.504662969 | Aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) |
| CD3D | 3.495196273 | CD3D antigen, delta polypeptide (TIT3 complex) |
| SLC7A7 | 3.490283635 | Solute carrier family 7 (cationic amino acid transporter, Y+ system), member 7 |
| CTSH | 3.489681294 | Cathepsin H |
| GRB2 | 3.47560278 | Growth factor receptor-bound protein 2 |
| SELL | 3.462829854 | Selectin L (lymphocyte adhesion molecule 1) |
| CCL3L3 | 3.452677466 | Chemokine (C-C MOTIF) ligand 3-like 1 |
| NA | 3.448890739 | NA |
| PHF11 | 3.446650391 | PHD finger protein 11 |
| DOCK8 | 3.446173435 | Dedicator of cytokinesis 8 |
| TRAC | 3.438194233 | T-cell receptor alpha constant |
| DAPP1 | 3.415611 | Dual adaptor of phosphotyrosine and 3-phosphoinositides |
| MPEG1 | 3.404638568 | Macrophage expressed gene 1 |
| NLRC5 | 3.399119856 | Nucleotide-binding oligomerization domains 27 |
| UGT1A10 | 3.374779661 | UDP glucuronosyltransferase 1 family, polypeptide A10 |
| LMO2 | 3.36809907 | LIM domain only 2 (rhombotin-like 1) |
| WARS | 3.349658421 | Interferon-induced protein 53 |
| CD74 | 3.340708593 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) |
| TRIM56 | 3.339288432 | Tripartite motif-containing 56 |
| CD53 | 3.330644072 | CD53 antigen |
| MGC39372 | 3.329207645 | Hypothetical protein MGC39372 |
| RPS6KB2 | 3.316673927 | Ribosomal protein S6 kinase, 70 kDa, polypeptide 2 |
| Symbol . | Score . | Gene name . |
|---|---|---|
| IRF9 | 7.63969424 | Interferon-stimulated transcription factor 3, gamma 48 kDa |
| IFI44 | 6.463064537 | Interferon-induced protein 44 |
| PARP9 | 6.331458105 | Poly (ADP-ribose) polymerase family, member 9 |
| OAS2 | 6.080896015 | 2′-5′-Oligoadenylate synthetase 2, 69/71kDa |
| ISG15 | 5.653887207 | Interferon, alpha-inducible protein (clone IFI-15K) |
| LAP3 | 5.562707184 | Leucine aminopeptidase 3 |
| IFITM1 | 5.309911759 | Interferon-induced transmembrane protein 1 (9-27) |
| SERPING1 | 5.295948182 | Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) |
| RNF213 | 5.268344777 | Chromosome 17 open reading frame 27 |
| SP110 | 5.256872524 | SP110 nuclear body protein |
| TRIM22 | 5.161555429 | Tripartite motif–containing 22 |
| STAT1 | 5.160281208 | Signal transducer and activator of transcription 1, 91 kDa |
| FGL2 | 5.059764921 | Fibrinogen-like 2 |
| MX1 | 5.052279793 | Myxovirus (influenza virus) resistance 1, interferon-inducible protein P78 (mouse) |
| HERC6 | 4.969209215 | HECT domain and RLD 6 |
| TAP1 | 4.925673126 | Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP) |
| IFIT2 | 4.851202317 | Interferon-induced protein with tetratricopeptide repeats 2 |
| TYROBP | 4.643418344 | Tyro protein tyrosine kinase binding protein |
| PSMB9 | 4.61684985 | Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) |
| ACOT7 | 4.474890582 | ACYL-COA thioesterase 7 |
| CCL4L2 | 4.435460418 | Chemokine (C-C motif) ligand 4 |
| GIMAP7 | 4.387779639 | GTPASE, IMAP family member 7 |
| IFIT3 | 4.377142549 | Interferon-induced protein with tetratricopeptide repeats 3 |
| STAT2 | 4.360968495 | Signal transducer and activator of transcription 2, 113 kDa |
| C1S | 4.356075207 | Complement component 1, S subcomponent |
| IFI35 | 4.297139761 | Interferon-induced protein 35 |
| IFITM4P | 4.23435714 | Interferon induced transmembrane protein 4 pseudogene |
| PNCK | 4.23295043 | Pregnancy up-regulated nonubiquitously expressed CAM kinase |
| ARHGAP25 | 4.190769686 | RHO GTPase activating protein 25 |
| GIMAP5 | 4.184925108 | GTPase, IMAP family member 5 |
| CXCL10 | 4.165976731 | Chemokine (C-X-C motif) ligand 10 |
| IL8RB | 4.152775449 | Interleukin 8 receptor, BETA |
| APOL3 | 4.134889167 | TNF-inducible protein CG12-1 |
| IFITM2 | 4.071757562 | Interferon induced transmembrane protein 2 (1-8D) |
| IL15 | 4.056626891 | Interleukin 15 |
| ZNFX1 | 3.992991172 | ZINC finger, NFX1-type containing 1 |
| CTSK | 3.987687377 | Cathepsin K (pycnodysostosis) |
| OASL | 3.972065117 | 2′-5′-Oligoadenylate synthetase-like |
| TRAalpha | 3.95014906 | T-cell receptor alpha locus |
| SRGN | 3.909639447 | Proteoglycan 1, secretory granule |
| CCL4L2 | 3.880280761 | Chemokine (C-C motif) ligand 4 |
| BTN3A3 | 3.862827621 | Butyrophilin, subfamily 3, member A3 |
| DTX3L | 3.834935982 | Deltex 3-like (drosophila) |
| NA | 3.812138625 | NA |
| CCL19 | 3.782911188 | Chemokine (C-C MOTIF) ligand 19 |
| ADAR | 3.779240486 | Adenosine deaminase, RNA specific |
| REC8 | 3.777102872 | REC8-like 1 (yeast) |
| KIAA1949 | 3.745843871 | KIAA1949 |
| ARL4C | 3.727007283 | ADP-ribosylation factor-like 4C |
| ARHGAP9 | 3.725234545 | RHO GTPase activating protein 9 |
| CORO1A | 3.715238075 | Coronin, actin binding protein, 1A |
| INDO | 3.67830532 | Indoleamine-pyrrole 2,3 dioxygenase |
| RAB31 | 3.67336941 | RAB31, member RAS oncogene family |
| COTL1 | 3.659705292 | Coactosin-like 1 (dictyostelium) |
| GMFG | 3.658192955 | GLIA maturation factor, GAMMA |
| SLA | 3.656310796 | SRC-like adaptor |
| BUB1 | 3.648122755 | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) |
| C1QA | 3.639355563 | Complement component 1, Q subcomponent, A chain |
| RAC2 | 3.632653776 | RAS-related C3 botulinum toxin substrate 2 (RHO family, small GTP binding protein RAC2) |
| CDC2 | 3.631566177 | Cell division cycle 2, G1 TO S and G2 to M |
| CLU | 3.626085643 | Clusterin |
| CCL3 | 3.621733073 | Chemokine (C-C MOTIF) ligand 3 |
| ECGF1 | 3.603371522 | Endothelial cell growth factor 1 (platelet-derived) |
| C1ORF54 | 3.599083135 | Chromosome 1 open reading frame 54 |
| HCLS1 | 3.598945235 | Hematopoietic cell-specific lyn substrate 1 |
| NA | 3.587802729 | NA |
| CCL4L2 | 3.584485049 | Chemokine (C-C MOTIF) ligand 4 |
| GBP2 | 3.584220194 | Guanylate binding protein 2, interferon-inducible |
| CXORF9 | 3.569357482 | Chromosome X open reading frame 9 |
| FAM14B | 3.552293235 | Family with sequence similarity 14, member B |
| EMILIN1 | 3.549670469 | Elastin microfibril interfacer 1 |
| PRPS2 | 3.539994216 | Phosphoribosyl pyrophosphate synthetase 1 |
| KIAA0082 | 3.530559508 | KIAA0082 |
| TSPAN14 | 3.527596769 | Tetraspanin 14 |
| FCER1G | 3.52450567 | Fc fragment of ige, high affinity I, receptor for gamma polypeptide |
| TREX1 | 3.514961993 | Three prime repair exonuclease 1 |
| VAMP1 | 3.510867551 | Vesicle-associated membrane protein 1 (synaptobrevin 1) |
| ALAS2 | 3.504662969 | Aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) |
| CD3D | 3.495196273 | CD3D antigen, delta polypeptide (TIT3 complex) |
| SLC7A7 | 3.490283635 | Solute carrier family 7 (cationic amino acid transporter, Y+ system), member 7 |
| CTSH | 3.489681294 | Cathepsin H |
| GRB2 | 3.47560278 | Growth factor receptor-bound protein 2 |
| SELL | 3.462829854 | Selectin L (lymphocyte adhesion molecule 1) |
| CCL3L3 | 3.452677466 | Chemokine (C-C MOTIF) ligand 3-like 1 |
| NA | 3.448890739 | NA |
| PHF11 | 3.446650391 | PHD finger protein 11 |
| DOCK8 | 3.446173435 | Dedicator of cytokinesis 8 |
| TRAC | 3.438194233 | T-cell receptor alpha constant |
| DAPP1 | 3.415611 | Dual adaptor of phosphotyrosine and 3-phosphoinositides |
| MPEG1 | 3.404638568 | Macrophage expressed gene 1 |
| NLRC5 | 3.399119856 | Nucleotide-binding oligomerization domains 27 |
| UGT1A10 | 3.374779661 | UDP glucuronosyltransferase 1 family, polypeptide A10 |
| LMO2 | 3.36809907 | LIM domain only 2 (rhombotin-like 1) |
| WARS | 3.349658421 | Interferon-induced protein 53 |
| CD74 | 3.340708593 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) |
| TRIM56 | 3.339288432 | Tripartite motif-containing 56 |
| CD53 | 3.330644072 | CD53 antigen |
| MGC39372 | 3.329207645 | Hypothetical protein MGC39372 |
| RPS6KB2 | 3.316673927 | Ribosomal protein S6 kinase, 70 kDa, polypeptide 2 |
FDR indicates false discovery rate; and PCA, principal component analysis.