Results of sequential studies of IDH1 mutations and chromosomal changes in the patients with the mutation at diagnosis
| Case no./interval, mo* . | Status . | Karyotype . | IDH1 mutation† . |
|---|---|---|---|
| 1 | Diagnosis | N | + |
| 0.5 | CR1 | N | No mutation |
| 4 | Diagnosis | N | + |
| 1.4 | CR1 | N | No mutation |
| 15.8 | Relapse 1 | del(13q) | + |
| 0.9 | CR2 | N | No mutation |
| 7 | Diagnosis | N | + |
| 1.3 | CR1 | N | No mutation |
| 11.5 | Relapse 1 | N | + |
| 4.1 | CR2 | ND | No mutation |
| 11.8 | Relapse 2 | ND | + |
| 8 | Diagnosis | Add (1)(p13), +8 | + |
| 1.1 | CR1 | ND | No mutation |
| 9 | Diagnosis | N | + |
| 3.7 | CR1 | ND | No mutation |
| 6.2 | Relapse 1 | ND | + |
| 10 | Diagnosis | N | + |
| 1.1 | CR1 | ND | No mutation |
| 8.1 | Relapse 1 | ND | + |
| 4.3 | CR2 | ND | No mutation |
| 2.2 | Relapse 2 | ND | + |
| 11 | Diagnosis | t (9;22)(q34;q11) | + |
| 6.3 | CR1 | ND | No mutation |
| 10.1 | Relapse 1 | ND | + |
| 12 | Diagnosis | N | + |
| 2.3 | CR1 | ND | No mutation |
| 3.0 | Relapse 1 | ND | + |
| 1.0 | CR2 | ND | No mutation |
| 13 | Diagnosis | +21 | + |
| 2.4 | CR1 | N | No mutation |
| 18.3 | Relapse 1 | N | + |
| 3.9 | CR2 | N | No mutation |
| 36.9 | Relapse 2 | N | +‡ |
| 14 | Diagnosis | N | + |
| 2.5 | CR1 | N | No mutation |
| 16 | Diagnosis | N | + |
| 0.9 | CR1 | N | No mutation |
| 17 | Diagnosis | N | + |
| 1.8 | CR1 | ND | No mutation |
| 10.1 | Relapse 1 | ND | +‡ |
| 19 | Diagnosis | N | + |
| 1.5 | CR1 | ND | No mutation |
| 20 | Diagnosis | N | + |
| 1.6 | CR1 | ND | No mutation |
| 21 | Diagnosis | N | + |
| 1.1 | CR1 | N | No mutation |
| 22 | Diagnosis | N | + |
| 7.0 | CR1 | ND | No mutation |
| 25 | Diagnosis | N | + |
| 6.1 | CR1 | ND | No mutation |
| 27 | Diagnosis | N | + |
| 0.8 | CR1 | N | No mutation |
| Case no./interval, mo* . | Status . | Karyotype . | IDH1 mutation† . |
|---|---|---|---|
| 1 | Diagnosis | N | + |
| 0.5 | CR1 | N | No mutation |
| 4 | Diagnosis | N | + |
| 1.4 | CR1 | N | No mutation |
| 15.8 | Relapse 1 | del(13q) | + |
| 0.9 | CR2 | N | No mutation |
| 7 | Diagnosis | N | + |
| 1.3 | CR1 | N | No mutation |
| 11.5 | Relapse 1 | N | + |
| 4.1 | CR2 | ND | No mutation |
| 11.8 | Relapse 2 | ND | + |
| 8 | Diagnosis | Add (1)(p13), +8 | + |
| 1.1 | CR1 | ND | No mutation |
| 9 | Diagnosis | N | + |
| 3.7 | CR1 | ND | No mutation |
| 6.2 | Relapse 1 | ND | + |
| 10 | Diagnosis | N | + |
| 1.1 | CR1 | ND | No mutation |
| 8.1 | Relapse 1 | ND | + |
| 4.3 | CR2 | ND | No mutation |
| 2.2 | Relapse 2 | ND | + |
| 11 | Diagnosis | t (9;22)(q34;q11) | + |
| 6.3 | CR1 | ND | No mutation |
| 10.1 | Relapse 1 | ND | + |
| 12 | Diagnosis | N | + |
| 2.3 | CR1 | ND | No mutation |
| 3.0 | Relapse 1 | ND | + |
| 1.0 | CR2 | ND | No mutation |
| 13 | Diagnosis | +21 | + |
| 2.4 | CR1 | N | No mutation |
| 18.3 | Relapse 1 | N | + |
| 3.9 | CR2 | N | No mutation |
| 36.9 | Relapse 2 | N | +‡ |
| 14 | Diagnosis | N | + |
| 2.5 | CR1 | N | No mutation |
| 16 | Diagnosis | N | + |
| 0.9 | CR1 | N | No mutation |
| 17 | Diagnosis | N | + |
| 1.8 | CR1 | ND | No mutation |
| 10.1 | Relapse 1 | ND | +‡ |
| 19 | Diagnosis | N | + |
| 1.5 | CR1 | ND | No mutation |
| 20 | Diagnosis | N | + |
| 1.6 | CR1 | ND | No mutation |
| 21 | Diagnosis | N | + |
| 1.1 | CR1 | N | No mutation |
| 22 | Diagnosis | N | + |
| 7.0 | CR1 | ND | No mutation |
| 25 | Diagnosis | N | + |
| 6.1 | CR1 | ND | No mutation |
| 27 | Diagnosis | N | + |
| 0.8 | CR1 | N | No mutation |
The data of sequential studies on 112 patients without IDH1 mutation at diagnosis were not shown in this table; none acquired IDH1 mutation at relapse in these patients.
CR indicates complete remission; N, normal; and ND, no data.
Between 2 consecutive studies.
All patients with IDH1 mutations are heterozygous.
The IDH1 mutations in these 2 relapsed samples could not be detected by sequencing of PCR products but were confirmed by sequencing of the individual clones.