Hematologic parameters of Tmprss6-Hjv genotype combinations
| Genotype . | RBC, ×1012/L . | Hgb, g/L . | Hct . | MCV, ×10−15L . | MCH, pg . | RDW, % . |
|---|---|---|---|---|---|---|
| Tmprss6+/+Hjv+/+ | 9.7 ± 0.1 | 154 ± 2 | 0.468 ± 0.004 | 48.5 ± 0.4 | 16.0 ± 0.1 | 19.4 ± 0.3 |
| Tmprss6+/−Hjv+/+ | 9.7 ± 0.2 | 151 ± 3 | 0.449 ± 0.009 | 46.3 ± 0.6* | 15.6 ± 0.1* | 20.1 ± 0.4 |
| Tmprss6−/−Hjv+/+ | 11.3 ± 0.3† | 117 ± 5† | 0.344 ± 0.015† | 30.6 ± 1.1† | 10.4 ± 0.3† | 36.4 ± 2.2† |
| Tmprss6+/+Hjv+/− | 9.9 ± 0.3 | 156 ± 2 | 0.472 ± 0.01 | 47.6 ± 0.4 | 15.8 ± 0.3 | 18.7 ± 0.5 |
| Tmprss6+/−Hjv+/− | 9.9 ± 0.3 | 155 ± 4 | 0.458 ± 0.01 | 46.5 ± 0.4* | 15.7 ± 0.1 | 19.8 ± 0.6 |
| Tmprss6−/−Hjv+/− | 11.2 ± 0.1†‡ | 116 ± 2†‡ | 0.343 ± 0.009†‡ | 30.7 ± 0.6†‡ | 10.3 ± 0.2†‡ | 37.2 ± 0.9†‡ |
| Tmprss6+/+Hjv−/− | 10.1 ± 0.2 | 159 ± 3 | 0.484 ± 0.008 | 47.7 ± 0.4 | 15.7 ± 0.3 | 19.8 ± 0.3 |
| Tmprss6+/−Hjv−/− | 9.9 ± 0.1 | 157 ± 2 | 0.473 ± 0.004 | 47.6 ± 0.6 | 15.8 ± 0.3 | 19.1 ± 0.3 |
| Tmprss6−/−Hjv−/− | 9.6 ± 0.2 | 154 ± 2 | 0.467 ± 0.009 | 48.5 ± 0.4 | 16.0 ± 0.3 | 18.4 ± 0.2* |
| Genotype . | RBC, ×1012/L . | Hgb, g/L . | Hct . | MCV, ×10−15L . | MCH, pg . | RDW, % . |
|---|---|---|---|---|---|---|
| Tmprss6+/+Hjv+/+ | 9.7 ± 0.1 | 154 ± 2 | 0.468 ± 0.004 | 48.5 ± 0.4 | 16.0 ± 0.1 | 19.4 ± 0.3 |
| Tmprss6+/−Hjv+/+ | 9.7 ± 0.2 | 151 ± 3 | 0.449 ± 0.009 | 46.3 ± 0.6* | 15.6 ± 0.1* | 20.1 ± 0.4 |
| Tmprss6−/−Hjv+/+ | 11.3 ± 0.3† | 117 ± 5† | 0.344 ± 0.015† | 30.6 ± 1.1† | 10.4 ± 0.3† | 36.4 ± 2.2† |
| Tmprss6+/+Hjv+/− | 9.9 ± 0.3 | 156 ± 2 | 0.472 ± 0.01 | 47.6 ± 0.4 | 15.8 ± 0.3 | 18.7 ± 0.5 |
| Tmprss6+/−Hjv+/− | 9.9 ± 0.3 | 155 ± 4 | 0.458 ± 0.01 | 46.5 ± 0.4* | 15.7 ± 0.1 | 19.8 ± 0.6 |
| Tmprss6−/−Hjv+/− | 11.2 ± 0.1†‡ | 116 ± 2†‡ | 0.343 ± 0.009†‡ | 30.7 ± 0.6†‡ | 10.3 ± 0.2†‡ | 37.2 ± 0.9†‡ |
| Tmprss6+/+Hjv−/− | 10.1 ± 0.2 | 159 ± 3 | 0.484 ± 0.008 | 47.7 ± 0.4 | 15.7 ± 0.3 | 19.8 ± 0.3 |
| Tmprss6+/−Hjv−/− | 9.9 ± 0.1 | 157 ± 2 | 0.473 ± 0.004 | 47.6 ± 0.6 | 15.8 ± 0.3 | 19.1 ± 0.3 |
| Tmprss6−/−Hjv−/− | 9.6 ± 0.2 | 154 ± 2 | 0.467 ± 0.009 | 48.5 ± 0.4 | 16.0 ± 0.3 | 18.4 ± 0.2* |
Complete blood counts were measured from whole blood of 8-week-old female mice of all possible Tmprss6-Hjv genotype combinations (6-8 mice per genotype). Data are presented as mean ± SEM.
RBC indicates red blood cell count; Hgb, hemoglobin; Hct, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; RDW, red cell distribution width; and Tf sat, transferrin saturation.
P < .05 compared with Tmprss6+/+Hjv+/+ mice.
P < .001 compared with Tmprss6+/+Hjv+/+ mice.
P value not significant compared with Tmprss6−/−Hjv+/+ mice.