Physical parameters and tissue parameters of Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice
| Genotype . | Body wt, g . | Spleen wt, mg . | Spleen-to-body-wt ratio, % . | Spleen NHI concentration, μg/g wet wt . | Total spleen NHI content, μg . |
|---|---|---|---|---|---|
| Tmprss6+/+ | 18 ± 1 | 68 ± 5 | 0.37 ± 0.02 | 131 ± 10 | 8.7 ± 0.8 |
| Tmprss6+/− | 19 ± 1 | 66 ± 1 | 0.35 ± 0.01 | 135 ± 11 | 8.9 ± 0.8 |
| Tmprss6−/− | 16 ± 1 | 86 ± 11 | 0.56 ± 0.04* | 160 ± 22 | 12.2 ± 1.7 |
| Genotype . | Body wt, g . | Spleen wt, mg . | Spleen-to-body-wt ratio, % . | Spleen NHI concentration, μg/g wet wt . | Total spleen NHI content, μg . |
|---|---|---|---|---|---|
| Tmprss6+/+ | 18 ± 1 | 68 ± 5 | 0.37 ± 0.02 | 131 ± 10 | 8.7 ± 0.8 |
| Tmprss6+/− | 19 ± 1 | 66 ± 1 | 0.35 ± 0.01 | 135 ± 11 | 8.9 ± 0.8 |
| Tmprss6−/− | 16 ± 1 | 86 ± 11 | 0.56 ± 0.04* | 160 ± 22 | 12.2 ± 1.7 |
Body weight, spleen weight, and spleen nonheme iron concentration were measured in 8-week-old female mice. Total spleen nonheme iron content was calculated by multiplying the spleen nonheme iron concentration by the spleen weight. The number of mice studied was as follows: Tmprss6+/+ (n = 7), Tmprss6+/− (n = 8), and Tmprss6−/− (body weight and spleen iron content, n = 8; spleen weight, n = 4). Data are presented as mean ± SEM.
wt indicates weight; and NHI, nonheme iron.
P < .05 compared with Tmprss6+/+ mice.