Hematologic and serum parameters of Tmprss6+/+, Tmprss6+/−, and Tmprss6−/− mice
| Genotype . | Whole blood . | Serum . | ||||||
|---|---|---|---|---|---|---|---|---|
| RBC, ×1012/L . | Hgb, g/L . | Hct . | MCV, ×10−15L . | MCH, pg . | RDW, % . | Iron, μM . | Tf sat, % . | |
| Tmprss6+/+ | 8.9 ± 0.1 | 141 ± 1 | 0.422 ± 0.006 | 47.4 ± 0.2 | 15.8 ± 0.1 | 18.4 ± 0.2 | 24.8 ± 1.5 | 61 ± 2 |
| Tmprss6+/− | 9.1 ± 0.1 | 137 ± 1 | 0.413 ± 0.004 | 45.7 ± 0.4* | 15.1 ± 0.1* | 18.6 ± 0.5 | 21.5 ± 1.4 | 55 ± 2 |
| Tmprss6−/− | 11.5 ± 0.3† | 99 ± 4† | 0.302 ± 0.01† | 26.2 ± 0.4† | 8.6 ± 0.2† | 42.0 ± 1.7† | 8.1 ± 0.5† | 18 ± 1† |
| Genotype . | Whole blood . | Serum . | ||||||
|---|---|---|---|---|---|---|---|---|
| RBC, ×1012/L . | Hgb, g/L . | Hct . | MCV, ×10−15L . | MCH, pg . | RDW, % . | Iron, μM . | Tf sat, % . | |
| Tmprss6+/+ | 8.9 ± 0.1 | 141 ± 1 | 0.422 ± 0.006 | 47.4 ± 0.2 | 15.8 ± 0.1 | 18.4 ± 0.2 | 24.8 ± 1.5 | 61 ± 2 |
| Tmprss6+/− | 9.1 ± 0.1 | 137 ± 1 | 0.413 ± 0.004 | 45.7 ± 0.4* | 15.1 ± 0.1* | 18.6 ± 0.5 | 21.5 ± 1.4 | 55 ± 2 |
| Tmprss6−/− | 11.5 ± 0.3† | 99 ± 4† | 0.302 ± 0.01† | 26.2 ± 0.4† | 8.6 ± 0.2† | 42.0 ± 1.7† | 8.1 ± 0.5† | 18 ± 1† |
Complete blood counts were measured from whole blood of, and iron and transferrin saturation were measured from serum of, 8-week-old female Tmprss6+/+ (n = 7), Tmprss6+/− (n = 8), and Tmprss6−/− (n = 8) mice. Data are presented as mean ± SEM.
RBC indicates red blood cell count; Hgb, hemoglobin; Hct, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; RDW, red cell distribution width; and Tf sat, transferrin saturation.
P < .005 compared with Tmprss6+/+ mice.
P < .001 compared with Tmprss6+/+ mice.