Results of the univariate and multivariate analyses
| . | Univariate analysis . | Multivariate analysis . | ||||
|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Age, y | ||||||
| 1-9 | 1 | 1 | ||||
| 10-17 | 1.68 | 1.32-2.14 | < .001 | 1.17 | 0.91-1.51 | .21 |
| WBC count, ×109/L | ||||||
| Lower than 50 | 1 | 1 | ||||
| 50-100 | 1.60 | 1.16-2.21 | .004 | 1.55 | 1.11-2.15 | .009 |
| 100 or higher | 2.41 | 1.73-3.34 | < .001 | 2.10 | 1.49-2.96 | < .001 |
| TEL/AML1* | ||||||
| Negative | 1 | 1 | ||||
| Positive | 0.47 | 0.35-0.63 | < .001 | 0.59 | 0.43-0.81 | < .001 |
| DNA index | ||||||
| Less than 1.16 or 1.6 or more | 1 | 1 | ||||
| 1.16 or more and less than 1.6 | 0.59 | 0.42-0.82 | .002 | 0.62 | 0.44-0.88 | .008 |
| Missing | 0.80 | 0.59-1.07 | .13 | 0.91 | 0.67-1.22 | .52 |
| Response to prednisone | ||||||
| Prednisone good responder | 1 | 1 | ||||
| Prednisone poor responder | 1.37 | 0.95-1.99 | .09 | 0.66 | 0.44-0.98 | .04 |
| PCR-MRD | ||||||
| MRD-SR | 1 | 1 | ||||
| MRD-IR | 3.83 | 2.86-5.12 | < .001 | 3.54 | 2.64-4.75 | < .001 |
| MRD-HR | 9.47 | 6.51-13.78 | < .001 | 7.51 | 5.06-11.15 | < .001 |
| . | Univariate analysis . | Multivariate analysis . | ||||
|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | |
| Age, y | ||||||
| 1-9 | 1 | 1 | ||||
| 10-17 | 1.68 | 1.32-2.14 | < .001 | 1.17 | 0.91-1.51 | .21 |
| WBC count, ×109/L | ||||||
| Lower than 50 | 1 | 1 | ||||
| 50-100 | 1.60 | 1.16-2.21 | .004 | 1.55 | 1.11-2.15 | .009 |
| 100 or higher | 2.41 | 1.73-3.34 | < .001 | 2.10 | 1.49-2.96 | < .001 |
| TEL/AML1* | ||||||
| Negative | 1 | 1 | ||||
| Positive | 0.47 | 0.35-0.63 | < .001 | 0.59 | 0.43-0.81 | < .001 |
| DNA index | ||||||
| Less than 1.16 or 1.6 or more | 1 | 1 | ||||
| 1.16 or more and less than 1.6 | 0.59 | 0.42-0.82 | .002 | 0.62 | 0.44-0.88 | .008 |
| Missing | 0.80 | 0.59-1.07 | .13 | 0.91 | 0.67-1.22 | .52 |
| Response to prednisone | ||||||
| Prednisone good responder | 1 | 1 | ||||
| Prednisone poor responder | 1.37 | 0.95-1.99 | .09 | 0.66 | 0.44-0.98 | .04 |
| PCR-MRD | ||||||
| MRD-SR | 1 | 1 | ||||
| MRD-IR | 3.83 | 2.86-5.12 | < .001 | 3.54 | 2.64-4.75 | < .001 |
| MRD-HR | 9.47 | 6.51-13.78 | < .001 | 7.51 | 5.06-11.15 | < .001 |
Cox model stratified by group (AIEOP and BFM) on hazard of relapse in 2927 pB-ALL (Ph−) patients (with 354 relapses) for whom information on most covariates was available.
CI indicates confidence interval; WBC, whtie blood cell; PCR-MRD, polymerase chain reaction minimal residual disease; SR, standard risk; IR, intermediate risk; and HR, high risk.