Adjusted negative binomial regression models for the effect of different levels of smoke exposure on rate of acute chest syndrome (ACS) and pain episodes in adults with SCD
| Variable . | Model 1: Effect of active smoking on the rates of ACS and pain events compared with those with no smoke exposure . | Model 2: Effect of passive smoking on the rates of ACS and pain events compared with those with no smoke exposure . | ||
|---|---|---|---|---|
| RR (95% CI) . | P . | RR (95% CI) . | P . | |
| ACS* | ||||
| Active smoking | 2.61 (1.24-5.51) | .01 | ||
| Environmental tobacco smoke exposure only | 2.62 (1.05-6.57) | .04 | ||
| Pain† | ||||
| Active smoking | 1.94 (1.04-3.62) | .04 | ||
| Environmental tobacco smoke exposure only | 1.59 (0.74-3.43) | .24 | ||
| Variable . | Model 1: Effect of active smoking on the rates of ACS and pain events compared with those with no smoke exposure . | Model 2: Effect of passive smoking on the rates of ACS and pain events compared with those with no smoke exposure . | ||
|---|---|---|---|---|
| RR (95% CI) . | P . | RR (95% CI) . | P . | |
| ACS* | ||||
| Active smoking | 2.61 (1.24-5.51) | .01 | ||
| Environmental tobacco smoke exposure only | 2.62 (1.05-6.57) | .04 | ||
| Pain† | ||||
| Active smoking | 1.94 (1.04-3.62) | .04 | ||
| Environmental tobacco smoke exposure only | 1.59 (0.74-3.43) | .24 | ||
ACS indicates acute chest syndrome; SCD, sickle cell disease; RR, relative risk; and CI, confidence interval.
Multivariable models of ACS were adjusted for SCD phenotype (HbSS/HbSβthal° vs others), age, hemoglobin, white blood cell count, history of asthma, hydroxyurea use.3,7
Multivariable models of pain were adjusted for SCD phenotype, age, sex, hemoglobin, history of asthma, hydroxyurea use.7,8