Table 3

Multivariate analysis of BAALC expression for clinical outcome in BCR-ABL and MLL-AF4 patients

VariableHROR95% CIP
Refractory disease*     
    BAALC expression, T1 vs T2 vs T3  4.2 1.4-12.3 .01 
    Immunophenotype    .01 
        Common vs pre-B  1.0 0.1-9.1 .98 
        Pro-B vs pre-B  14 1.1-176 .04 
Overall survival*     
    BAALC expression, T1 vs T2 vs T3 1.4  1.0-2.0 .03 
    WBC more than 30 × 109/L 3.9  2.2-6.9 < .001 
    Age, 10-year increase 1.5  1.3-1.8 < .001 
VariableHROR95% CIP
Refractory disease*     
    BAALC expression, T1 vs T2 vs T3  4.2 1.4-12.3 .01 
    Immunophenotype    .01 
        Common vs pre-B  1.0 0.1-9.1 .98 
        Pro-B vs pre-B  14 1.1-176 .04 
Overall survival*     
    BAALC expression, T1 vs T2 vs T3 1.4  1.0-2.0 .03 
    WBC more than 30 × 109/L 3.9  2.2-6.9 < .001 
    Age, 10-year increase 1.5  1.3-1.8 < .001 

HR indicates hazard ratio; and OR, odds ratio.

*

Variables considered for model inclusion are described in "Statistical analyses." The final model is shown.

Patients who received SCT in CR1 were censored at the time of transplantation.

Overall P value for the variable immunophenotype.

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