Disease-related events
| . | Total events . | Fatal events . |
|---|---|---|
| Infections* | ||
| Pneumonia | 6 | 0 |
| Bacterial meningitis | 4 | 0 |
| Sepsis | 4 | 2 |
| Gastrointestinal (salmonellosis) | 1 | 1 |
| Orchitis | 1 | 0 |
| Tuberculosis | 1 | 0 |
| No. of events | 17† | 3‡ |
| No. of patients | 12 | 3 |
| Bleeding§ | ||
| ICH∥ | 18 | 3 |
| Gastrointestinal | 6 | 1 |
| Ear/nose/throat | 4 | 0 |
| Pulmonary | 2 | 1 |
| Traumatic, not ICH | 2 | 0 |
| Retinal | 1 | 0 |
| No. of events | 33 | 5 |
| No. of patients | 24 | 5 |
| Autoimmunity¶ | ||
| Nephropathy | 9 | 0 |
| AIHA | 6 | 0 |
| Vasculitis | 3 | 0 |
| ITP | 4 | 0 |
| Arthritis | 3 | 0 |
| Colitis | 1 | 0 |
| No. of events | 26 | 0 |
| No. of patients | 21 | 0 |
| Malignancy# | ||
| Lymphoma/EBV-LPD | 4 | 1 |
| MDS | 1 | 0 |
| Spinalioma | 2 | 0 |
| Seminoma | 1 | 0 |
| ALL | 1 | 0 |
| Pancreatic cancer | 1 | 1 |
| No. of events | 10 | 2 |
| No. of patients | 9 | 2 |
| . | Total events . | Fatal events . |
|---|---|---|
| Infections* | ||
| Pneumonia | 6 | 0 |
| Bacterial meningitis | 4 | 0 |
| Sepsis | 4 | 2 |
| Gastrointestinal (salmonellosis) | 1 | 1 |
| Orchitis | 1 | 0 |
| Tuberculosis | 1 | 0 |
| No. of events | 17† | 3‡ |
| No. of patients | 12 | 3 |
| Bleeding§ | ||
| ICH∥ | 18 | 3 |
| Gastrointestinal | 6 | 1 |
| Ear/nose/throat | 4 | 0 |
| Pulmonary | 2 | 1 |
| Traumatic, not ICH | 2 | 0 |
| Retinal | 1 | 0 |
| No. of events | 33 | 5 |
| No. of patients | 24 | 5 |
| Autoimmunity¶ | ||
| Nephropathy | 9 | 0 |
| AIHA | 6 | 0 |
| Vasculitis | 3 | 0 |
| ITP | 4 | 0 |
| Arthritis | 3 | 0 |
| Colitis | 1 | 0 |
| No. of events | 26 | 0 |
| No. of patients | 21 | 0 |
| Malignancy# | ||
| Lymphoma/EBV-LPD | 4 | 1 |
| MDS | 1 | 0 |
| Spinalioma | 2 | 0 |
| Seminoma | 1 | 0 |
| ALL | 1 | 0 |
| Pancreatic cancer | 1 | 1 |
| No. of events | 10 | 2 |
| No. of patients | 9 | 2 |
ICH indicates intracranial hemorrhage; AIHA, autoimmune hemolytic anemia; ITP, immune thrombocytopenic purpura; ALL, acute lymphoblastic leukemia; EBV-LPD, Epstein-Barr virus–associated lymphoproliferative disease; and MDS, myelodysplastic syndrome.
Three patients had more than 1 infectious event.
Eight events were in patients who had undergone a previous splenectomy.
Two events were in patients who had undergone a previous splenectomy.
Four patients had more than 1 bleeding episode.
Fifteen were spontaneous, 3 were traumatic.
Three patients had more than 1 autoimmune disease.
One patient had 2 malignancies.