Leukemia-initiating cells are abundant in zebrafish T-ALL
| T-ALL donor . | Recipients per experiment . | LIC frequency . | 95% Confidence . | Correlation R2 value . |
|---|---|---|---|---|
| T-ALL #5-primary leukemia | 44 | 1/250 | 1/94 to 1/663 | 0.9802 |
| T-ALL #5-transplanted leukemia | 42 | 1/57 | 1/30 to 1/110 | 0.9982 |
| T-ALL #6-primary leukemia | 46 | 1/71 | 1/37 to 1/139 | 0.9917 |
| T-ALL #6-transplanted leukemia | 40 | 1/60 | 1/32 to 1/114 | 0.9112 |
| T-ALL #7-primary leukemia | 40 | 1/77 | 1/39 to 1/151 | 0.999 |
| T-ALL #7-transplanted leukemia | 41 | 1/135 | 1/59 to 1/306 | 0.9859 |
| T-ALL #8-primary leukemia | 35 | 1/845* | 1/277 to 1/1212 | 0.9852 |
| T-ALL donor . | Recipients per experiment . | LIC frequency . | 95% Confidence . | Correlation R2 value . |
|---|---|---|---|---|
| T-ALL #5-primary leukemia | 44 | 1/250 | 1/94 to 1/663 | 0.9802 |
| T-ALL #5-transplanted leukemia | 42 | 1/57 | 1/30 to 1/110 | 0.9982 |
| T-ALL #6-primary leukemia | 46 | 1/71 | 1/37 to 1/139 | 0.9917 |
| T-ALL #6-transplanted leukemia | 40 | 1/60 | 1/32 to 1/114 | 0.9112 |
| T-ALL #7-primary leukemia | 40 | 1/77 | 1/39 to 1/151 | 0.999 |
| T-ALL #7-transplanted leukemia | 41 | 1/135 | 1/59 to 1/306 | 0.9859 |
| T-ALL #8-primary leukemia | 35 | 1/845* | 1/277 to 1/1212 | 0.9852 |
LIC frequency and 95% confidence intervals were calculated by the L-calc program, and correlation coefficient R2 values show how well the data fit by use of the Bonnefoix limiting dilution method.
LIC indicates leukemia-initiating cell; and T-ALL, T-cell acute lymphoblastic leukemia.
Sample T-ALL 8 = primary leukemia is significantly different from all other samples (P < .05) except sample T-ALL 5 = primary leukemia. The raw data used to calculate LIC frequency are shown in supplemental Table 4.