Table 2

Dysregulated miRNAs in MCL

Chromosomal locationAverage level in MCL samplesAverage level in normal CD19+ cellsFold change (MCL/N)P
Down-regulated      
    hsa-miR-142-3p 17q23.2 0.494 2.918 0.17 < .001 
    hsa-miR-142-5p 17q23.2 0.142 0.721 0.20 < .001 
    hsa-miR-27a 19p13.12 0.067 0.256 0.26 .004 
    hsa-miR-21 17q23.2 0.162 0.6 0.27 .004 
    hsa-miR-29b 7q32.3 0.192 0.685 0.28 .003 
    hsa-let-7a 9q22.32 0.053 0.183 0.29 .87 
    hsa-miR-29a 7q32.3 0.137 0.486 0.28 .008 
    hsa-miR-195 17p13.1 0.081 0.28 0.29 .99 
    hsa-miR-29c 1q32.2 0.18 0.512 0.35 .002 
    hsa-miR-150 19q13.33 0.14 0.379 0.37 .007 
    hsa-miR-27b 9q22.32 0.096 0.23 0.42 .03 
    hsa-miR-15b 3q25.33 0.17 0.39 0.44 .79 
    hsa-miR-16 13q14.2 0.094 0.197 0.48 .38 
    hsa-miR-26b 2q35 0.149 0.309 0.48 .08 
    hsa-miR-30b 8q24.22 0.097 0.185 0.52 .67 
    hsa-miR-26a 3p22.3 0.229 0.407 0.56 .11 
    hsa-miR-30a-5p 6q13 0.095 0.156 0.61 .23 
    hsa-miR-15a 13q14.2 0.195 0.298 0.65 .37 
Up-regulated      
    hsa-miR-124a 8p23.1 1.111 0.162 6.86 .003 
    hsa-miR-210 11p15.5 1.358 0.202 6.72 .05 
    hsa-miR-361 Xq21.2 1.405 0.259 5.42 .06 
    hsa-miR-373* 19q13.42 31.953 6.228 5.13 .05 
    hsa-miR-374 Xq13.2 2.967 0.59 5.03 .08 
    hsa-miR-375 2q35 1.45 0.309 4.69 .09 
    hsa-miR-328 16q22.1 1.66 0.38 4.37 .02 
    hsa-miR-372 19q13.42 1.661 0.426 3.90 .06 
    hsa-miR-384 Xq21.1 0.734 0.193 3.80 .1 
    hsa-miR-345 14q32.2 3.582 0.944 3.79 .03 
    hsa-miR-302c 4q25 4.727 1.415 3.34 .03 
    hsa-miR-362 Xp11.22 1.371 0.423 3.24 .07 
    hsa-miR-326 11q13.4 2.329 0.728 3.20 .07 
    hsa-miR-155 21q21.3 1.486 0.515 2.89 .02 
    hsa-miR-369-3p 14q32.31 0.229 0.083 2.76 .06 
    hsa-miR-433 14q32.31 0.983 0.357 2.75 .06 
    hsa-miR-342 14q32.2 1.129 0.411 2.75 .08 
    hsa-miR-453 14q32.31 4.088 1.493 2.74 .07 
    hsa-miR-367 4q25 0.263 0.098 2.68 .1 
    hsa-miR-325 Xq21.1 0.364 0.143 2.55 .05 
    has-miR-17-5p 13q21.1 1.08 0.715 1.51 .08 
Chromosomal locationAverage level in MCL samplesAverage level in normal CD19+ cellsFold change (MCL/N)P
Down-regulated      
    hsa-miR-142-3p 17q23.2 0.494 2.918 0.17 < .001 
    hsa-miR-142-5p 17q23.2 0.142 0.721 0.20 < .001 
    hsa-miR-27a 19p13.12 0.067 0.256 0.26 .004 
    hsa-miR-21 17q23.2 0.162 0.6 0.27 .004 
    hsa-miR-29b 7q32.3 0.192 0.685 0.28 .003 
    hsa-let-7a 9q22.32 0.053 0.183 0.29 .87 
    hsa-miR-29a 7q32.3 0.137 0.486 0.28 .008 
    hsa-miR-195 17p13.1 0.081 0.28 0.29 .99 
    hsa-miR-29c 1q32.2 0.18 0.512 0.35 .002 
    hsa-miR-150 19q13.33 0.14 0.379 0.37 .007 
    hsa-miR-27b 9q22.32 0.096 0.23 0.42 .03 
    hsa-miR-15b 3q25.33 0.17 0.39 0.44 .79 
    hsa-miR-16 13q14.2 0.094 0.197 0.48 .38 
    hsa-miR-26b 2q35 0.149 0.309 0.48 .08 
    hsa-miR-30b 8q24.22 0.097 0.185 0.52 .67 
    hsa-miR-26a 3p22.3 0.229 0.407 0.56 .11 
    hsa-miR-30a-5p 6q13 0.095 0.156 0.61 .23 
    hsa-miR-15a 13q14.2 0.195 0.298 0.65 .37 
Up-regulated      
    hsa-miR-124a 8p23.1 1.111 0.162 6.86 .003 
    hsa-miR-210 11p15.5 1.358 0.202 6.72 .05 
    hsa-miR-361 Xq21.2 1.405 0.259 5.42 .06 
    hsa-miR-373* 19q13.42 31.953 6.228 5.13 .05 
    hsa-miR-374 Xq13.2 2.967 0.59 5.03 .08 
    hsa-miR-375 2q35 1.45 0.309 4.69 .09 
    hsa-miR-328 16q22.1 1.66 0.38 4.37 .02 
    hsa-miR-372 19q13.42 1.661 0.426 3.90 .06 
    hsa-miR-384 Xq21.1 0.734 0.193 3.80 .1 
    hsa-miR-345 14q32.2 3.582 0.944 3.79 .03 
    hsa-miR-302c 4q25 4.727 1.415 3.34 .03 
    hsa-miR-362 Xp11.22 1.371 0.423 3.24 .07 
    hsa-miR-326 11q13.4 2.329 0.728 3.20 .07 
    hsa-miR-155 21q21.3 1.486 0.515 2.89 .02 
    hsa-miR-369-3p 14q32.31 0.229 0.083 2.76 .06 
    hsa-miR-433 14q32.31 0.983 0.357 2.75 .06 
    hsa-miR-342 14q32.2 1.129 0.411 2.75 .08 
    hsa-miR-453 14q32.31 4.088 1.493 2.74 .07 
    hsa-miR-367 4q25 0.263 0.098 2.68 .1 
    hsa-miR-325 Xq21.1 0.364 0.143 2.55 .05 
    has-miR-17-5p 13q21.1 1.08 0.715 1.51 .08 

P values are the comparison of miRNA expression patterns in 30 MCL samples with those of 5 samples from healthy donors' lymphocytes.

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