Table 1 Clinical and laboratory... | American Society of Hematology

Table 1

Clinical and laboratory parameters of the patients with VWD2B enrolled in the study listed according to mutations of the VWF A1 domain

Patient no.	Mutation	Bleeding score	Platelet count, × 10⁹/L	RIPA, mg/mL	VWF:Ag, U/dL	VWF:RCo, U/dL	FVIII:C, U/dL	VWF:RCo/Ag ratio	HMW/ intermediate multimers
P1	P1266L	6	251	0.4	59	45	57	0.76	Present/normal
P2	R1306W	12	175	0.6	45	28	51	0.62	Absent/partial loss
P3	R1308C	9	121	0.5	54	21	45	0.39	Absent/complete loss
P4	I1309V	9	96	0.3	160	125	140	0.78	Absent/normal
P5	V1316M	13	274	0.6	33	12	6	0.21	Absent/complete loss
P6	V1316M	17	60	0.25	70	25	52	0.4	Absent/complete loss
P7	R1341Q	9	98	0.25	95	70	69	0.7	Absent/partial loss
P8	R1341Q	10	120	0.5	79	48	47	0.6	Absent/partial loss
P9	R1341W	9	195	0.4	72	42	73	0.58	Absent/partial loss

Patient no.	Mutation	Bleeding score	Platelet count, × 10⁹/L	RIPA, mg/mL	VWF:Ag, U/dL	VWF:RCo, U/dL	FVIII:C, U/dL	VWF:RCo/Ag ratio	HMW/ intermediate multimers
P1	P1266L	6	251	0.4	59	45	57	0.76	Present/normal
P2	R1306W	12	175	0.6	45	28	51	0.62	Absent/partial loss
P3	R1308C	9	121	0.5	54	21	45	0.39	Absent/complete loss
P4	I1309V	9	96	0.3	160	125	140	0.78	Absent/normal
P5	V1316M	13	274	0.6	33	12	6	0.21	Absent/complete loss
P6	V1316M	17	60	0.25	70	25	52	0.4	Absent/complete loss
P7	R1341Q	9	98	0.25	95	70	69	0.7	Absent/partial loss
P8	R1341Q	10	120	0.5	79	48	47	0.6	Absent/partial loss
P9	R1341W	9	195	0.4	72	42	73	0.58	Absent/partial loss

VWF:Ag indicates VWF antigen; VWF:RCo: VWF as ristocetin cofactor activity; FVIII:C, procoagulant activity of FVIII; VWF:RCo/Ag, calculated ratio with antigen; and HMW/intermediate, high-molecular-weight vs intermediate multimers.

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