Genes and fold changes
| Symbol . | Official gene name . | Foldchange . |
|---|---|---|
| Up-regulation | ||
| Ms4a2 | Membrane-spanning 4-domains, subfamily A, member 2 (Fcer1b)*† | 14.88 |
| Rgs13 | Regulator of G-protein signaling 13* | 7.03 |
| Alox5ap | Arachidonate 5-lipoxygenase activating protein* | 6.39 |
| Fcer1a | Fc receptor, IgE, high affinity I, α polypeptide* | 4.51 |
| Scin | Scinderin* | 3.77 |
| Enpp1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1* | 3.39 |
| Cpd | Carboxypeptidase D* | 3.02 |
| Gzmb | Granzyme B* | 2.73 |
| Cd63 | cd63 antigen* | 2.57 |
| Alox5 | Arachidonate 5-lipoxygenase* | 2.56 |
| Ikzf2 | IKAROS family zinc finger 2 (Helios)* | 2.29 |
| Gata2 | GATA-binding protein 2*† | 2.24 |
| Itpkb | Inositol 1,4,5-trisphosphate 3-kinase B | 2.11 |
| Blnk | B-cell linker | 1.98 |
| Pf4 | Platelet factor 4† | 1.96 |
| Prg2 | Proteoglycan 2, bone marrow* | 1.83 |
| Il12rb2 | Interleukin-12 receptor, β2* | 1.82 |
| Nrarp | Notch-regulated ankyrin repeat protein | 1.78 |
| Klf6 | Kruppel-like factor 6 | 1.77 |
| Mmd | Monocyte to macrophage differentiation-associated | 1.74 |
| Pbx1 | Pre B-cell leukemia transcription factor 1 | 1.72 |
| Sla | Src-like adaptor | 1.65 |
| Malt1 | Mucosa associated lymphoid tissue lymphoma translocation gene 1 | 1.64 |
| Lair1 | Leukocyte-associated Ig-like receptor 1 | 1.62 |
| Klhl6 | Kelch-like 6 (Drosophila) | 1.61 |
| Ptger3 | Prostaglandin E receptor 3 (subtype EP3)* | 1.60 |
| Ptpn22 | Protein tyrosine phosphatase, nonreceptor type 22 (lymphoid) | 1.59 |
| Irak3 | Interleukin-1 receptor-associated kinase 3 | 1.56 |
| Rag1ap1 | Recombination activating gene 1 activating protein 1(Ms4 family)* | 1.55 |
| Fyb | FYN-binding protein* | 1.55 |
| Down-regulation | ||
| Anxa5 | Annexin A5 | −4.68 |
| Grb10 | Growth factor receptor bound protein 10 | −4.20 |
| Prelid2 | PRELI domain containing 2 | −3.90 |
| Cecr2 | Cat eye syndrome chromosome region, candidate 2 homolog (human) | −3.45 |
| Mfhas1 | Malignant fibrous histiocytoma amplified sequence 1 | −3.22 |
| Sh2d4a | SH2 domain containing 4A | −3.15 |
| Cnn3 | Calponin 3, acidic | −2.67 |
| Il2rg | Interleukin-2 receptor, γ chain | −2.53 |
| Hrasls3 | HRAS-like suppressor 3 | −2.37 |
| Thyn1 | Thymocyte nuclear protein 1 | −1.86 |
| Epha7 | Eph receptor A7 | −1.81 |
| Ifitm2 | Interferon-induced transmembrane protein 2 | −1.72 |
| Il10rb | Interleukin-10 receptor, β | −1.71 |
| Ifngr1 | Interferon-γ receptor 1 | −1.66 |
| Hebp1 | Heme-binding protein 1† | −1.62 |
| Il31ra | Interleukin-31 receptor A | −1.56 |
| Crlf3 | Cytokine receptor-like factor 3 | −1.55 |
| Ctla2a | Cytotoxic T lymphocyte-associated protein 2 α | −1.54 |
| Cd82 | CD82 antigen | −1.52 |
| Xk | Kell blood group precursor (McLeod phenotype) homolog | −1.51 |
| Il1r1 | Interleukin-1 receptor, type I | −1.50 |
| Symbol . | Official gene name . | Foldchange . |
|---|---|---|
| Up-regulation | ||
| Ms4a2 | Membrane-spanning 4-domains, subfamily A, member 2 (Fcer1b)*† | 14.88 |
| Rgs13 | Regulator of G-protein signaling 13* | 7.03 |
| Alox5ap | Arachidonate 5-lipoxygenase activating protein* | 6.39 |
| Fcer1a | Fc receptor, IgE, high affinity I, α polypeptide* | 4.51 |
| Scin | Scinderin* | 3.77 |
| Enpp1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1* | 3.39 |
| Cpd | Carboxypeptidase D* | 3.02 |
| Gzmb | Granzyme B* | 2.73 |
| Cd63 | cd63 antigen* | 2.57 |
| Alox5 | Arachidonate 5-lipoxygenase* | 2.56 |
| Ikzf2 | IKAROS family zinc finger 2 (Helios)* | 2.29 |
| Gata2 | GATA-binding protein 2*† | 2.24 |
| Itpkb | Inositol 1,4,5-trisphosphate 3-kinase B | 2.11 |
| Blnk | B-cell linker | 1.98 |
| Pf4 | Platelet factor 4† | 1.96 |
| Prg2 | Proteoglycan 2, bone marrow* | 1.83 |
| Il12rb2 | Interleukin-12 receptor, β2* | 1.82 |
| Nrarp | Notch-regulated ankyrin repeat protein | 1.78 |
| Klf6 | Kruppel-like factor 6 | 1.77 |
| Mmd | Monocyte to macrophage differentiation-associated | 1.74 |
| Pbx1 | Pre B-cell leukemia transcription factor 1 | 1.72 |
| Sla | Src-like adaptor | 1.65 |
| Malt1 | Mucosa associated lymphoid tissue lymphoma translocation gene 1 | 1.64 |
| Lair1 | Leukocyte-associated Ig-like receptor 1 | 1.62 |
| Klhl6 | Kelch-like 6 (Drosophila) | 1.61 |
| Ptger3 | Prostaglandin E receptor 3 (subtype EP3)* | 1.60 |
| Ptpn22 | Protein tyrosine phosphatase, nonreceptor type 22 (lymphoid) | 1.59 |
| Irak3 | Interleukin-1 receptor-associated kinase 3 | 1.56 |
| Rag1ap1 | Recombination activating gene 1 activating protein 1(Ms4 family)* | 1.55 |
| Fyb | FYN-binding protein* | 1.55 |
| Down-regulation | ||
| Anxa5 | Annexin A5 | −4.68 |
| Grb10 | Growth factor receptor bound protein 10 | −4.20 |
| Prelid2 | PRELI domain containing 2 | −3.90 |
| Cecr2 | Cat eye syndrome chromosome region, candidate 2 homolog (human) | −3.45 |
| Mfhas1 | Malignant fibrous histiocytoma amplified sequence 1 | −3.22 |
| Sh2d4a | SH2 domain containing 4A | −3.15 |
| Cnn3 | Calponin 3, acidic | −2.67 |
| Il2rg | Interleukin-2 receptor, γ chain | −2.53 |
| Hrasls3 | HRAS-like suppressor 3 | −2.37 |
| Thyn1 | Thymocyte nuclear protein 1 | −1.86 |
| Epha7 | Eph receptor A7 | −1.81 |
| Ifitm2 | Interferon-induced transmembrane protein 2 | −1.72 |
| Il10rb | Interleukin-10 receptor, β | −1.71 |
| Ifngr1 | Interferon-γ receptor 1 | −1.66 |
| Hebp1 | Heme-binding protein 1† | −1.62 |
| Il31ra | Interleukin-31 receptor A | −1.56 |
| Crlf3 | Cytokine receptor-like factor 3 | −1.55 |
| Ctla2a | Cytotoxic T lymphocyte-associated protein 2 α | −1.54 |
| Cd82 | CD82 antigen | −1.52 |
| Xk | Kell blood group precursor (McLeod phenotype) homolog | −1.51 |
| Il1r1 | Interleukin-1 receptor, type I | −1.50 |
Microarray analysis of gene expression in wild-type and Fog1 mutant megakaryocyte-erythroid progenitors. Representative genes implicated in various stages of hematopoiesis, erythropoiesis, immune system development, or of unknown function are shown as “fold change” relative to wild-type. P < .01; n = 3 experiments.
Genes known to be expressed in mast cells.
Genes known to be regulated by GATA factors.