Univariate analysis of cumulative incidence of clinically significant (II-IV and III-IV) acute GVHD in association with HPSE gene SNPs combination and their discrepancy in related versus unrelated transplants
| Grade . | Donor type . | SNPs combination/ group of discrepancy . | Cumulative incidence, % . | 95% CI for cumulative incidence . | χ2/P . |
|---|---|---|---|---|---|
| II-IV | Related | HR | 48.3 | 36.2-64.4 | 7.2/.027 |
| MR | 40.5 | 31.1-52.7 | |||
| LR | 25.8 | 16.9-39.4 | |||
| III-IV | HR | 35.7 | 24.4-52.4 | 8.9/.012 | |
| MR | 25.7 | 17.2-38.2 | |||
| LR | 13.7 | 7.2-26.2 | |||
| II-IV | Unrelated | HR | 63.6 | 49.3-82.2 | 12.7/.002 |
| MR | 40.6 | 29.9-54.9 | |||
| LR | 23.4 | 13.2-41.6 | |||
| III-IV | HR | 53.4 | 37.7-75.7 | 17.2/< .001 | |
| MR | 15.7 | 8.5-28.8 | |||
| LR | 13.7 | 6.0-31.3 | |||
| II-IV | Related | D1 | 70.4 | 51.7-95.9 | 14.4/< .001 |
| D2 | 40.5 | 31.6-52.0 | |||
| D3 | 25.8 | 16.9-39.4 | |||
| III-IV | D1 | 52.9 | 32.5-86.3 | 12.8/.002 | |
| D2 | 25.9 | 17.9-37.6 | |||
| D3 | 13.7 | 7.2-26.2 | |||
| II-IV | Unrelated | D1 | 72.5 | 56.0-93.9 | 14.1/< .001 |
| D2 | 43.0 | 32.3-57.3 | |||
| D3 | 23.4 | 13.2-41.6 | |||
| III-IV | D1 | 66.9 | 48.5-92.5 | 21.2/< .001 | |
| D2 | 18.7 | 10.9-32.1 | |||
| D3 | 13.7 | 6.0-31.3 |
| Grade . | Donor type . | SNPs combination/ group of discrepancy . | Cumulative incidence, % . | 95% CI for cumulative incidence . | χ2/P . |
|---|---|---|---|---|---|
| II-IV | Related | HR | 48.3 | 36.2-64.4 | 7.2/.027 |
| MR | 40.5 | 31.1-52.7 | |||
| LR | 25.8 | 16.9-39.4 | |||
| III-IV | HR | 35.7 | 24.4-52.4 | 8.9/.012 | |
| MR | 25.7 | 17.2-38.2 | |||
| LR | 13.7 | 7.2-26.2 | |||
| II-IV | Unrelated | HR | 63.6 | 49.3-82.2 | 12.7/.002 |
| MR | 40.6 | 29.9-54.9 | |||
| LR | 23.4 | 13.2-41.6 | |||
| III-IV | HR | 53.4 | 37.7-75.7 | 17.2/< .001 | |
| MR | 15.7 | 8.5-28.8 | |||
| LR | 13.7 | 6.0-31.3 | |||
| II-IV | Related | D1 | 70.4 | 51.7-95.9 | 14.4/< .001 |
| D2 | 40.5 | 31.6-52.0 | |||
| D3 | 25.8 | 16.9-39.4 | |||
| III-IV | D1 | 52.9 | 32.5-86.3 | 12.8/.002 | |
| D2 | 25.9 | 17.9-37.6 | |||
| D3 | 13.7 | 7.2-26.2 | |||
| II-IV | Unrelated | D1 | 72.5 | 56.0-93.9 | 14.1/< .001 |
| D2 | 43.0 | 32.3-57.3 | |||
| D3 | 23.4 | 13.2-41.6 | |||
| III-IV | D1 | 66.9 | 48.5-92.5 | 21.2/< .001 | |
| D2 | 18.7 | 10.9-32.1 | |||
| D3 | 13.7 | 6.0-31.3 |
D1: HR-LR, HR-MR recipient-donor genotype combinations pairs. D2: MR-MR, MR-HR, MR-LR, HR-HR recipient-donor genotype combinations pairs. D3: LR-LR, LR-HR, LR-MR recipient-donor genotype combinations pairs. Significant deviations (P < .05) are marked in bold.