Table 1

Monoclonal antibodies

Designation*IsotypeSpecificity
3E7/H17 Murine IgG1 C3b, iC3b 
1H8 Murine IgG2a C3b, iC3b, C3dg 
7C12 Murine IgG1 C3b, iC3b 
5G9§ Murine IgG2a C3b, iC3b 
8B3 Murine IgG1 Tumor necrosis factor 
CD59 Murine IgG2a CD59 
Designation*IsotypeSpecificity
3E7/H17 Murine IgG1 C3b, iC3b 
1H8 Murine IgG2a C3b, iC3b, C3dg 
7C12 Murine IgG1 C3b, iC3b 
5G9§ Murine IgG2a C3b, iC3b 
8B3 Murine IgG1 Tumor necrosis factor 
CD59 Murine IgG2a CD59 

mAb indicates monoclonal antibody.

*

When mAbs are fluorescently labeled, the fluorochrome is included in the name of the mAb (eg, Al647 mAb H17 is mAb H17 labeled with Al647).

Blocks the alternative pathway of complement. H17 is a chimeric-deimmunized version of 3E7.

Nonoverlapping epitopes.

§

Blocks the classical pathway of complement.

Used as an isotype matched control.

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