Growth inhibitory profile of KW-2449
| Cell lines . | KW-2449 . | Imatinib . |
|---|---|---|
| 32D transfectant | ||
| Mock (with IL-3) | > 10 | — |
| FLT3/ITD | 0.024 | — |
| FLT3/D835Y | 0.046 | — |
| Wt-FLT3/FL | 0.014 | — |
| Human leukemia | ||
| MOLM-13 | 0.024 | > 10 |
| MV4;11 | 0.011 | — |
| RS4;11 | 0.23 | 20 |
| HL-60 | 0.65 | > 10 |
| BCR/ABL+ leukemia | ||
| K562 | 0.27 | 0.24 |
| TCC-Y | 0.49 | 0.18 |
| TCC-Y/sr | 0.42 | 24 |
| Cell lines . | KW-2449 . | Imatinib . |
|---|---|---|
| 32D transfectant | ||
| Mock (with IL-3) | > 10 | — |
| FLT3/ITD | 0.024 | — |
| FLT3/D835Y | 0.046 | — |
| Wt-FLT3/FL | 0.014 | — |
| Human leukemia | ||
| MOLM-13 | 0.024 | > 10 |
| MV4;11 | 0.011 | — |
| RS4;11 | 0.23 | 20 |
| HL-60 | 0.65 | > 10 |
| BCR/ABL+ leukemia | ||
| K562 | 0.27 | 0.24 |
| TCC-Y | 0.49 | 0.18 |
| TCC-Y/sr | 0.42 | 24 |
Growth inhibition GI50 (μmol/L). GI50 values of KW-2449 and imatinib were determined by in vitro XTT assays. MOLM-13 and MV4;11 cells had FLT3/ITD. K562 and TCC-Y cells had wt-BCR/ABL, and TCC-Y/sr had the T315I mutation in the BCR/ABL gene.
— indicates not applicable.