Kinase inhibitory profile of KW-2449
| Kinase . | KW-2449 . |
|---|---|
| Tyrosine kinase | |
| FLT3 | 0.0066 |
| FLT3/D835Y | 0.001 |
| KIT | 0.30 |
| PDFGRα | 1.7 |
| ABL | 0.014 |
| ABL-T315I | 0.004 |
| SRC | 0.40 |
| JAK2 | 0.15 |
| FGFR1 | 0.036 |
| Serine/threonine kinase | |
| Aurora A | 0.048 |
| Kinase . | KW-2449 . |
|---|---|
| Tyrosine kinase | |
| FLT3 | 0.0066 |
| FLT3/D835Y | 0.001 |
| KIT | 0.30 |
| PDFGRα | 1.7 |
| ABL | 0.014 |
| ABL-T315I | 0.004 |
| SRC | 0.40 |
| JAK2 | 0.15 |
| FGFR1 | 0.036 |
| Serine/threonine kinase | |
| Aurora A | 0.048 |
In vitro kinase inhibition IC50 (μmol/L). IC50 values of KW-2449 were determined by in vitro kinase assays as described in “Kinase inhibition profile.”