Meta-analysis of the associations of TMPRSS6 SNPs with iron and iron-related traits
| . | InCHIANTI . | BLSA . | WHASI . | WHASII . | Meta-analysis . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) . | P . | β (SE) . | P . | β (SE) . | P . | β (SE) . | P . | β (SE) . | P . | |
| rs855791 | ||||||||||
| Iron, μg/dL | 3.22 (1.05) | .001 | 7.21 (1.64) | 2.66 × 10−5 | 3.33 (1.93) | .092 | 3.16 (2.73) | .218 | 4.11 (0.77) | 4.16 × 10−8 |
| Red blood cell width, percentage | −0.09 (0.04) | .005 | −0.12 (0.05) | .004 | 0.03 (0.12) | .662 | −0.29 (0.12) | .054 | −0.10 (0.03) | 1.13 × 10−4 |
| Mean corpuscular volume, fL | 0.57 (0.20) | .007 | 0.39 (0.23) | .040 | 0.19 (0.45) | .519 | 0.11 (0.52) | .927 | 0.44 (0.14) | .001 |
| Hemoglobin, g/dL | 0.12 (0.05) | .006 | 0.11 (0.08) | .182 | −0.15 (0.10) | .120 | 0.08 (0.11) | .872 | 0.08 (0.04) | .040 |
| Hematocrit, percentage | 0.27 (0.13) | .028 | 0.24 (0.25) | .351 | −0.51 (0.30) | .100 | −0.07 (0.32) | .563 | 0.14 (0.10) | .221 |
| Red blood cells, n, 106/μL | −0.004 (0.02) | .858 | 0.010 (0.03) | .878 | −0.068 (0.03) | .062 | −0.010 (0.04) | .772 | −0.010 (0.01) | .393 |
| Platelets, 1000/μL | −0.64 (2.70) | .522 | −7.48 (8.31) | .519 | 0.61 (6.24) | .830 | 1.53 (5.70) | .496 | −0.64 (2.19) | .495 |
| Ferritin, ng/mL | 6.54 (5.68) | .677 | 7.15 (6.56) | .070 | −5.48 (10.88) | .294 | −6.10 (10.18) | .459 | 3.64 (3.72) | .592 |
| rs4820268 | ||||||||||
| Iron, μg/dL | 3.15 (1.03) | .002 | 7.31 (1.66) | 3.09 × 10−5 | 4.49 (1.93) | .021 | 5.02 (2.72) | .058 | 4.39 (0.76) | 5.12 × 10−9 |
| Red blood cell width, percentage | −0.07 (0.04) | .033 | −0.12 (0.05) | .002 | 0.02 (0.12) | .883 | −0.28 (0.12) | .078 | −0.10 (0.03) | 3.98 × 10−4 |
| Mean corpuscular volume, fL | 0.45 (0.19) | .032 | 0.56 (0.24) | .004 | 0.43 (0.45) | .206 | 0.43 (0.53) | .464 | 0.48 (0.14) | 1.86 × 10−4 |
| Hemoglobin, g/dL | 0.12 (0.05) | .007 | 0.11 (0.08) | .162 | −0.08 (0.10) | .423 | 0.06 (0.11) | .970 | 0.08 (0.04) | .020 |
| Hematocrit, percentage | 0.27 (0.12) | .019 | 0.22 (0.26) | .427 | −0.25 (0.30) | .425 | −0.19 (0.32) | .367 | 0.16 (0.10) | .136 |
| Red blood cells, 106/μL | 0.002 (0.02) | .805 | −0.001 (0.03) | .834 | −0.049 (0.03) | .187 | −0.036 (0.03) | .290 | −0.010 (0.01) | .453 |
| Platelets, 1000/μL | −0.99 (2.64) | .444 | −6.19 (8.39) | .551 | −4.53 (6.26) | .405 | 3.85 (5.76) | .260 | −1.08 (2.17) | .390 |
| Ferritin, ng/mL | 5.77 (5.56) | .936 | 11.19 (6.66) | .055 | 2.64 (10.99) | .725 | 0.25 (10.20) | .948 | 6.36 (3.71) | .479 |
| . | InCHIANTI . | BLSA . | WHASI . | WHASII . | Meta-analysis . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| β (SE) . | P . | β (SE) . | P . | β (SE) . | P . | β (SE) . | P . | β (SE) . | P . | |
| rs855791 | ||||||||||
| Iron, μg/dL | 3.22 (1.05) | .001 | 7.21 (1.64) | 2.66 × 10−5 | 3.33 (1.93) | .092 | 3.16 (2.73) | .218 | 4.11 (0.77) | 4.16 × 10−8 |
| Red blood cell width, percentage | −0.09 (0.04) | .005 | −0.12 (0.05) | .004 | 0.03 (0.12) | .662 | −0.29 (0.12) | .054 | −0.10 (0.03) | 1.13 × 10−4 |
| Mean corpuscular volume, fL | 0.57 (0.20) | .007 | 0.39 (0.23) | .040 | 0.19 (0.45) | .519 | 0.11 (0.52) | .927 | 0.44 (0.14) | .001 |
| Hemoglobin, g/dL | 0.12 (0.05) | .006 | 0.11 (0.08) | .182 | −0.15 (0.10) | .120 | 0.08 (0.11) | .872 | 0.08 (0.04) | .040 |
| Hematocrit, percentage | 0.27 (0.13) | .028 | 0.24 (0.25) | .351 | −0.51 (0.30) | .100 | −0.07 (0.32) | .563 | 0.14 (0.10) | .221 |
| Red blood cells, n, 106/μL | −0.004 (0.02) | .858 | 0.010 (0.03) | .878 | −0.068 (0.03) | .062 | −0.010 (0.04) | .772 | −0.010 (0.01) | .393 |
| Platelets, 1000/μL | −0.64 (2.70) | .522 | −7.48 (8.31) | .519 | 0.61 (6.24) | .830 | 1.53 (5.70) | .496 | −0.64 (2.19) | .495 |
| Ferritin, ng/mL | 6.54 (5.68) | .677 | 7.15 (6.56) | .070 | −5.48 (10.88) | .294 | −6.10 (10.18) | .459 | 3.64 (3.72) | .592 |
| rs4820268 | ||||||||||
| Iron, μg/dL | 3.15 (1.03) | .002 | 7.31 (1.66) | 3.09 × 10−5 | 4.49 (1.93) | .021 | 5.02 (2.72) | .058 | 4.39 (0.76) | 5.12 × 10−9 |
| Red blood cell width, percentage | −0.07 (0.04) | .033 | −0.12 (0.05) | .002 | 0.02 (0.12) | .883 | −0.28 (0.12) | .078 | −0.10 (0.03) | 3.98 × 10−4 |
| Mean corpuscular volume, fL | 0.45 (0.19) | .032 | 0.56 (0.24) | .004 | 0.43 (0.45) | .206 | 0.43 (0.53) | .464 | 0.48 (0.14) | 1.86 × 10−4 |
| Hemoglobin, g/dL | 0.12 (0.05) | .007 | 0.11 (0.08) | .162 | −0.08 (0.10) | .423 | 0.06 (0.11) | .970 | 0.08 (0.04) | .020 |
| Hematocrit, percentage | 0.27 (0.12) | .019 | 0.22 (0.26) | .427 | −0.25 (0.30) | .425 | −0.19 (0.32) | .367 | 0.16 (0.10) | .136 |
| Red blood cells, 106/μL | 0.002 (0.02) | .805 | −0.001 (0.03) | .834 | −0.049 (0.03) | .187 | −0.036 (0.03) | .290 | −0.010 (0.01) | .453 |
| Platelets, 1000/μL | −0.99 (2.64) | .444 | −6.19 (8.39) | .551 | −4.53 (6.26) | .405 | 3.85 (5.76) | .260 | −1.08 (2.17) | .390 |
| Ferritin, ng/mL | 5.77 (5.56) | .936 | 11.19 (6.66) | .055 | 2.64 (10.99) | .725 | 0.25 (10.20) | .948 | 6.36 (3.71) | .479 |
Effect allele rs855791 (C, average frequency = 0.59), rs4820268 (A, average frequency = 0.54).