Main immunohistochemical markers enabling the distinction of MCL from other lymphomas
| Histologic subtype . | CD5 . | CD23 . | CD43 . | CD10 . | BCL6 . | Cyclin D1 . | sIg . | sIg type . | cIg . |
|---|---|---|---|---|---|---|---|---|---|
| MCL | + | − | + | − | − | + | + | M ± D | − |
| Follicular lymphoma | − | −/+ | − | +/− | + | − | + | G ± M | − |
| Small lymphocytic lymphoma/CLL | + | + | + | − | − | − | + | M ± D | −/+ |
| Lymphoplasmacytic lymphoma | − | − | −/+ | − | − | − | +/− | M | + |
| Splenic marginal zone lymphoma | − | − | − | − | − | − | + | M+ D | −/+ |
| Extranodal marginal zone lymphoma (MALT type) | − | −/+ | −/+ | − | − | − | + | M | +/− |
| Histologic subtype . | CD5 . | CD23 . | CD43 . | CD10 . | BCL6 . | Cyclin D1 . | sIg . | sIg type . | cIg . |
|---|---|---|---|---|---|---|---|---|---|
| MCL | + | − | + | − | − | + | + | M ± D | − |
| Follicular lymphoma | − | −/+ | − | +/− | + | − | + | G ± M | − |
| Small lymphocytic lymphoma/CLL | + | + | + | − | − | − | + | M ± D | −/+ |
| Lymphoplasmacytic lymphoma | − | − | −/+ | − | − | − | +/− | M | + |
| Splenic marginal zone lymphoma | − | − | − | − | − | − | + | M+ D | −/+ |
| Extranodal marginal zone lymphoma (MALT type) | − | −/+ | −/+ | − | − | − | + | M | +/− |
MCL differential diagnosis is not always straightforward, and immunohistochemical studies are usually needed: the most typical immunophenotypic features of indolent mature B-cell neoplasms are summarized.
sIg indicates surface immunoglobulin; cIg, cytoplasmic immunoglobulin; +, > 90% positive; +/−, > 50% positive; −/+, < 50% positive; and −, < 10% positive.