Discriminant analysis function of 4-biomarker gene subset
| Gene discriminant power* . | ||||
|---|---|---|---|---|
| Gene† . | Microarray . | Quantitative RT-PCR . | ||
| JAK2 (GG) . | JAK2 (GT/TT) . | JAK2 (GG) . | JAK2 (GT/TT) . | |
| HIST1H1A | 91.6 | 36.4 | 93.8 | 37.5 |
| SRP72 | 91.6 | 36.4 | 87.5 | 0.0 |
| C20orf103 | 16.7 | 100 | 37.5 | 75.0 |
| CRYM | 75 | 54.6 | 87.5 | 25.0 |
| Gene discriminant power* . | ||||
|---|---|---|---|---|
| Gene† . | Microarray . | Quantitative RT-PCR . | ||
| JAK2 (GG) . | JAK2 (GT/TT) . | JAK2 (GG) . | JAK2 (GT/TT) . | |
| HIST1H1A | 91.6 | 36.4 | 93.8 | 37.5 |
| SRP72 | 91.6 | 36.4 | 87.5 | 0.0 |
| C20orf103 | 16.7 | 100 | 37.5 | 75.0 |
| CRYM | 75 | 54.6 | 87.5 | 25.0 |
Discriminant power of each individual gene was determined by entering only the given gene in the LDA. The gene discriminant power is the percentage of a given group correctly classified using one specific gene; thus, an entry of 100 means that all subjects in the given group were correctly classified. HIST1H1A indicates histone cluster 1, H1a; SRP72, signal recognition particle 72 kDa; C20orf, chromosome 20 open reading frame; and CRYM, crystallin, μ.
Classification includes aggregate data from the training set (cohort 1) using cross-validation, and test set (cohort 2) via prediction based on the training data.