Patient characteristics
| Characteristic . | ET*† (n = 40) . | RT*‡ (n = 38) . | Healthy controls§ (n = 48) . |
|---|---|---|---|
| Sex, no. (%) | |||
| Male | 15 (38) | 16 (42) | 23 (48) |
| Female | 25 (52) | 22 (58) | 25 (52) |
| Age group, no. (%) | |||
| Younger than 35 y | 3 (8) | 9 (24) | 16 (33) |
| 36-60 y | 13 (32) | 24 (63) | 27 (57) |
| 60 y or older | 24 (60) | 5 (13) | 5 (10) |
| Platelet count, ×10−3/mm3 | |||
| Mean | 659 | 632 | 246 |
| Range | 203-1724 | 173-1044 | 160-415 |
| Hemoglobin, g/dL | |||
| Mean | 13.3 | 10.9 | 14.1 |
| Range | 9.5-20.8 | 8.1-15.3 | 12.3-15.9 |
| White cell count, × 10−3/mm3 | |||
| Mean | 10.2 | 14.9 | 6.3 |
| Range | 3.1-44.6 | 5.7-65.2 | 4.4-9.6 |
| JAK2 genotype, no. (%) | |||
| V617F heterozygous | 21 (52) | 0 (0) | 0 (0) |
| V617F homozygous | 3 (8) | 0 (0) | 0 (0) |
| Normal | 16 (40) | 38 (100) | 48 (100) |
| Characteristic . | ET*† (n = 40) . | RT*‡ (n = 38) . | Healthy controls§ (n = 48) . |
|---|---|---|---|
| Sex, no. (%) | |||
| Male | 15 (38) | 16 (42) | 23 (48) |
| Female | 25 (52) | 22 (58) | 25 (52) |
| Age group, no. (%) | |||
| Younger than 35 y | 3 (8) | 9 (24) | 16 (33) |
| 36-60 y | 13 (32) | 24 (63) | 27 (57) |
| 60 y or older | 24 (60) | 5 (13) | 5 (10) |
| Platelet count, ×10−3/mm3 | |||
| Mean | 659 | 632 | 246 |
| Range | 203-1724 | 173-1044 | 160-415 |
| Hemoglobin, g/dL | |||
| Mean | 13.3 | 10.9 | 14.1 |
| Range | 9.5-20.8 | 8.1-15.3 | 12.3-15.9 |
| White cell count, × 10−3/mm3 | |||
| Mean | 10.2 | 14.9 | 6.3 |
| Range | 3.1-44.6 | 5.7-65.2 | 4.4-9.6 |
| JAK2 genotype, no. (%) | |||
| V617F heterozygous | 21 (52) | 0 (0) | 0 (0) |
| V617F homozygous | 3 (8) | 0 (0) | 0 (0) |
| Normal | 16 (40) | 38 (100) | 48 (100) |
Splenomegaly was identified in 14 of 40 ET patients (35.0%) and in 2 of 38 RT patients (5.3%).
At the time of platelet isolation, 12 patients were being treated with hydroxyurea, 12 patients with anagrelide, 1 patient with both hydroxyurea and anagrelide, 1 patient with pegylated interferon alfa-2b, and 14 patients were untreated.
Underlying patient diagnoses associated with RT included the following: infection (19), malignancy (14), other (3), and inflammatory diseases (2).
Complete blood counts are from random subset of 10 males and 10 females.